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Therapeutic potential of the endocannabinoid system in the brain.
Mini Rev Med Chem 2005; 5(7):609-17MR

Abstract

Cannabinoids have been predominantly considered as the substances responsible of the psychoactive properties of marijuana and other derivatives of Cannabis sativa. However, these compounds are now being also considered for their therapeutic potential, since the term "cannabinoid" includes much more compounds than those present in Cannabis sativa derivatives. Among them, there are numerous synthetic cannabinoids obtained by modifications from plant-derived cannabinoids, but also from the compounds that behave as endogenous ligands for the different cannabinoid receptor subtypes. Within the family of "cannabinoid-related compounds", one should also include some prototypes of selective antagonists for these receptors, and also the recently developed inhibitors of the mechanism of finalization of the biological action of endocannabinoids (transporter + FAAH). All this boom of the cannabinoid pharmacology has, therefore, an explanation in the recent discovery and characterization of the endocannabinoid signaling system, which plays a modulatory role mainly in the brain but also in the periphery. The objective of the present article will be to review, from pharmacological and biochemical points of view, the more recent advances in the study of the endocannabinoid system and their functions in the brain, as well as their alterations in a variety of pathologies and the proposed therapeutic benefits of novel cannabinoid-related compounds that improve the pharmacokinetic and pharmacodynamic properties of classic cannabinoids.

Authors+Show Affiliations

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain. jara@med.ucm.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16026307

Citation

Ramos, José Antonio, et al. "Therapeutic Potential of the Endocannabinoid System in the Brain." Mini Reviews in Medicinal Chemistry, vol. 5, no. 7, 2005, pp. 609-17.
Ramos JA, González S, Sagredo O, et al. Therapeutic potential of the endocannabinoid system in the brain. Mini Rev Med Chem. 2005;5(7):609-17.
Ramos, J. A., González, S., Sagredo, O., Gómez-Ruiz, M., & Fernández-Ruiz, J. (2005). Therapeutic potential of the endocannabinoid system in the brain. Mini Reviews in Medicinal Chemistry, 5(7), pp. 609-17.
Ramos JA, et al. Therapeutic Potential of the Endocannabinoid System in the Brain. Mini Rev Med Chem. 2005;5(7):609-17. PubMed PMID: 16026307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic potential of the endocannabinoid system in the brain. AU - Ramos,José Antonio, AU - González,Sara, AU - Sagredo,Onintza, AU - Gómez-Ruiz,María, AU - Fernández-Ruiz,Javier, PY - 2005/7/20/pubmed PY - 2005/9/2/medline PY - 2005/7/20/entrez SP - 609 EP - 17 JF - Mini reviews in medicinal chemistry JO - Mini Rev Med Chem VL - 5 IS - 7 N2 - Cannabinoids have been predominantly considered as the substances responsible of the psychoactive properties of marijuana and other derivatives of Cannabis sativa. However, these compounds are now being also considered for their therapeutic potential, since the term "cannabinoid" includes much more compounds than those present in Cannabis sativa derivatives. Among them, there are numerous synthetic cannabinoids obtained by modifications from plant-derived cannabinoids, but also from the compounds that behave as endogenous ligands for the different cannabinoid receptor subtypes. Within the family of "cannabinoid-related compounds", one should also include some prototypes of selective antagonists for these receptors, and also the recently developed inhibitors of the mechanism of finalization of the biological action of endocannabinoids (transporter + FAAH). All this boom of the cannabinoid pharmacology has, therefore, an explanation in the recent discovery and characterization of the endocannabinoid signaling system, which plays a modulatory role mainly in the brain but also in the periphery. The objective of the present article will be to review, from pharmacological and biochemical points of view, the more recent advances in the study of the endocannabinoid system and their functions in the brain, as well as their alterations in a variety of pathologies and the proposed therapeutic benefits of novel cannabinoid-related compounds that improve the pharmacokinetic and pharmacodynamic properties of classic cannabinoids. SN - 1389-5575 UR - https://www.unboundmedicine.com/medline/citation/16026307/Therapeutic_potential_of_the_endocannabinoid_system_in_the_brain_ L2 - http://www.eurekaselect.com/79786/article DB - PRIME DP - Unbound Medicine ER -