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Metabolic characteristics and insulin resistance of impaired fasting glucose among the middle-aged and elderly Taiwanese.
Diabetes Res Clin Pract. 2006 Feb; 71(2):170-6.DR

Abstract

Impaired fasting glucose (IFG), a newly defined category of glycemic metabolism, has gained extensive attentions after the introduction of the diagnostic criteria of diabetes mellitus (DM) by the American Diabetes Association. To explore the metabolic characteristics of IFG, we conducted this prospective community-based study among people aged more than 40 years residing in three major townships of I-Lan, an agricultural county in Taiwan. People attending the annual health examinations in community health stations were recruited for study. Experienced research staff recorded the past medical history, performed comprehensive physical examinations, and drew blood for further laboratory tests for each subject. Insulin resistance was evaluated by homeostasis model assessment (HOMA), and the renal hemodynamics was evaluated by estimated glomerular filtration rate (GFR). In total, 824 subjects (mean age=64.4+/-11.3 years, M:F=366:458) participated this study, the overall prevalence of DM was 15.3% (8.7% previously undiagnosed), and the prevalence of IFG was 7.2%. Lipid profiles including serum levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride of subjects with IFG were basically indistinguishable from subjects with DM. Insulin resistance was significantly associated with the progression of glycemic metabolism (HOMA-IR of subjects with normal fasting glucose, IFG, and DM were 1.12+/-1.24, 1.88+/-1.64, 4.47+/-5.12, P<0.001). However, the prevalence of metabolic syndrome was similar among subjects of IFG and DM (86.4 versus 85.6%). The prevalence of overt proteinuria was significantly increased as the glycemic metabolism progressed. The mean GFR was slightly increased in subjects with IFG, which may represent hyperfiltration in this category. In conclusion, metabolic characteristics of IFG were complex. Lipid profile and prevalence of metabolic syndrome of IFG were indistinguishable from DM, but renal hemodynamics and prevalence of overt proteinuria were intermediate between NFG and DM. To prevent or delay the onset of type 2 DM, aggressive lifestyle modifications should be engaged in our clinical practice for subjects with IFG.

Authors+Show Affiliations

Department of Family Medicine, Taipei Veterans General Hospital, No. 201, Shih-Pai Road Sec 2, Taipei 11217, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

16026886

Citation

Chen, Liang-Kung, et al. "Metabolic Characteristics and Insulin Resistance of Impaired Fasting Glucose Among the Middle-aged and Elderly Taiwanese." Diabetes Research and Clinical Practice, vol. 71, no. 2, 2006, pp. 170-6.
Chen LK, Lin MH, Chen ZJ, et al. Metabolic characteristics and insulin resistance of impaired fasting glucose among the middle-aged and elderly Taiwanese. Diabetes Res Clin Pract. 2006;71(2):170-6.
Chen, L. K., Lin, M. H., Chen, Z. J., Hwang, S. J., Tsai, S. T., & Chiou, S. T. (2006). Metabolic characteristics and insulin resistance of impaired fasting glucose among the middle-aged and elderly Taiwanese. Diabetes Research and Clinical Practice, 71(2), 170-6.
Chen LK, et al. Metabolic Characteristics and Insulin Resistance of Impaired Fasting Glucose Among the Middle-aged and Elderly Taiwanese. Diabetes Res Clin Pract. 2006;71(2):170-6. PubMed PMID: 16026886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic characteristics and insulin resistance of impaired fasting glucose among the middle-aged and elderly Taiwanese. AU - Chen,Liang-Kung, AU - Lin,Ming-Hsien, AU - Chen,Zhi-Jun, AU - Hwang,Shinn-Jang, AU - Tsai,Shih-Tzer, AU - Chiou,Shu-Ti, Y1 - 2005/07/18/ PY - 2004/11/30/received PY - 2005/03/04/revised PY - 2005/05/26/accepted PY - 2005/7/20/pubmed PY - 2006/6/14/medline PY - 2005/7/20/entrez SP - 170 EP - 6 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 71 IS - 2 N2 - Impaired fasting glucose (IFG), a newly defined category of glycemic metabolism, has gained extensive attentions after the introduction of the diagnostic criteria of diabetes mellitus (DM) by the American Diabetes Association. To explore the metabolic characteristics of IFG, we conducted this prospective community-based study among people aged more than 40 years residing in three major townships of I-Lan, an agricultural county in Taiwan. People attending the annual health examinations in community health stations were recruited for study. Experienced research staff recorded the past medical history, performed comprehensive physical examinations, and drew blood for further laboratory tests for each subject. Insulin resistance was evaluated by homeostasis model assessment (HOMA), and the renal hemodynamics was evaluated by estimated glomerular filtration rate (GFR). In total, 824 subjects (mean age=64.4+/-11.3 years, M:F=366:458) participated this study, the overall prevalence of DM was 15.3% (8.7% previously undiagnosed), and the prevalence of IFG was 7.2%. Lipid profiles including serum levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride of subjects with IFG were basically indistinguishable from subjects with DM. Insulin resistance was significantly associated with the progression of glycemic metabolism (HOMA-IR of subjects with normal fasting glucose, IFG, and DM were 1.12+/-1.24, 1.88+/-1.64, 4.47+/-5.12, P<0.001). However, the prevalence of metabolic syndrome was similar among subjects of IFG and DM (86.4 versus 85.6%). The prevalence of overt proteinuria was significantly increased as the glycemic metabolism progressed. The mean GFR was slightly increased in subjects with IFG, which may represent hyperfiltration in this category. In conclusion, metabolic characteristics of IFG were complex. Lipid profile and prevalence of metabolic syndrome of IFG were indistinguishable from DM, but renal hemodynamics and prevalence of overt proteinuria were intermediate between NFG and DM. To prevent or delay the onset of type 2 DM, aggressive lifestyle modifications should be engaged in our clinical practice for subjects with IFG. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/16026886/Metabolic_characteristics_and_insulin_resistance_of_impaired_fasting_glucose_among_the_middle_aged_and_elderly_Taiwanese_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(05)00224-X DB - PRIME DP - Unbound Medicine ER -