Tags

Type your tag names separated by a space and hit enter

Three-year survey of community-acquired methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin in a French university hospital.
J Hosp Infect. 2005 Dec; 61(4):321-9.JH

Abstract

A retrospective survey was conducted at Bicêtre Hospital, France from January 2001 to September 2003 to screen for S. aureus isolates with a typical phenotype previously involved in necrotizing pneumonia in France. They were resistant to oxacillin and kanamycin, of intermediate susceptibility to fusidic acid, and susceptible to tobramycin and fluoroquinolones. Seventeen isolates were found and 16 were viable. The Panton-Valentine leukocidin (PVL) genes, various toxin genes and SCCmec IV and agr3 alleles were detected in all isolates. The clonal origin of these isolates was demonstrated by pulsed-field gel electrophoresis. Fourteen isolates were community-acquired methicillin-resistant Staphylococcus (CA-MRSA) isolated from previously healthy patients with skin or soft tissue infections. Three infections were of nosocomial origin, underlining that these PVL-producing CA-MRSA strains may also be hospital acquired. Five CA-MRSA isolates with an identical resistance phenotype collected in a neighbouring teaching hospital (Hôpital Pitié-Salpétrière, Paris, France) were also PVL positive. Three isolates were clonally related to those of the Bicêtre Hospital whereas two were not. This retrospective study identified PVL-producing CA-MRSA in two Parisian hospitals. The incidence at Bicêtre Hospital was 0.8% of all S. aureus and 2% of all MRSA isolated. Our data indicate that these MRSA isolates might become hospital acquired.

Authors+Show Affiliations

Service de Bactériologie-Virologie-Hygiène, Hôpital de Bicêtre, Assistance Publique, Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France. thierry.naas@vct.ap-hop-pairs.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16026895

Citation

Naas, T, et al. "Three-year Survey of Community-acquired Methicillin-resistant Staphylococcus Aureus Producing Panton-Valentine Leukocidin in a French University Hospital." The Journal of Hospital Infection, vol. 61, no. 4, 2005, pp. 321-9.
Naas T, Fortineau N, Spicq C, et al. Three-year survey of community-acquired methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin in a French university hospital. J Hosp Infect. 2005;61(4):321-9.
Naas, T., Fortineau, N., Spicq, C., Robert, J., Jarlier, V., & Nordmann, P. (2005). Three-year survey of community-acquired methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin in a French university hospital. The Journal of Hospital Infection, 61(4), 321-9.
Naas T, et al. Three-year Survey of Community-acquired Methicillin-resistant Staphylococcus Aureus Producing Panton-Valentine Leukocidin in a French University Hospital. J Hosp Infect. 2005;61(4):321-9. PubMed PMID: 16026895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three-year survey of community-acquired methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin in a French university hospital. AU - Naas,T, AU - Fortineau,N, AU - Spicq,C, AU - Robert,J, AU - Jarlier,V, AU - Nordmann,P, Y1 - 2005/07/18/ PY - 2004/12/15/received PY - 2005/01/28/accepted PY - 2005/7/20/pubmed PY - 2006/4/1/medline PY - 2005/7/20/entrez SP - 321 EP - 9 JF - The Journal of hospital infection JO - J. Hosp. Infect. VL - 61 IS - 4 N2 - A retrospective survey was conducted at Bicêtre Hospital, France from January 2001 to September 2003 to screen for S. aureus isolates with a typical phenotype previously involved in necrotizing pneumonia in France. They were resistant to oxacillin and kanamycin, of intermediate susceptibility to fusidic acid, and susceptible to tobramycin and fluoroquinolones. Seventeen isolates were found and 16 were viable. The Panton-Valentine leukocidin (PVL) genes, various toxin genes and SCCmec IV and agr3 alleles were detected in all isolates. The clonal origin of these isolates was demonstrated by pulsed-field gel electrophoresis. Fourteen isolates were community-acquired methicillin-resistant Staphylococcus (CA-MRSA) isolated from previously healthy patients with skin or soft tissue infections. Three infections were of nosocomial origin, underlining that these PVL-producing CA-MRSA strains may also be hospital acquired. Five CA-MRSA isolates with an identical resistance phenotype collected in a neighbouring teaching hospital (Hôpital Pitié-Salpétrière, Paris, France) were also PVL positive. Three isolates were clonally related to those of the Bicêtre Hospital whereas two were not. This retrospective study identified PVL-producing CA-MRSA in two Parisian hospitals. The incidence at Bicêtre Hospital was 0.8% of all S. aureus and 2% of all MRSA isolated. Our data indicate that these MRSA isolates might become hospital acquired. SN - 0195-6701 UR - https://www.unboundmedicine.com/medline/citation/16026895/Three_year_survey_of_community_acquired_methicillin_resistant_Staphylococcus_aureus_producing_Panton_Valentine_leukocidin_in_a_French_university_hospital_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0195-6701(05)00108-8 DB - PRIME DP - Unbound Medicine ER -