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Association study between the D10S1423 microsatellite marker and Alzheimer's disease.
Neurobiol Aging. 2006 May; 27(5):776.e1-776.e3.NA

Abstract

Several studies have reported conflicting results concerning the genetic association between Alzheimer's disease (AD) and the microsatellite marker D10S1423 on chromosome 10p12-14. In an ethnically homogeneous German population of 422 patients with AD and 254 cognitively healthy controls, the 238-bp allele of the D10S1423 marker showed a weak, but after correction for multiple testing no longer significant association with AD (p = 0.015, uncorrected; p = 0.11, corrected). These findings do not support the presence of a relevant susceptibility locus for AD on chromosome 10p12-14.

Authors+Show Affiliations

Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München (TUM), Ismaningerstr. 22, D-81675 Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16026902

Citation

Gohlke, H, et al. "Association Study Between the D10S1423 Microsatellite Marker and Alzheimer's Disease." Neurobiology of Aging, vol. 27, no. 5, 2006, pp. 776.e1-776.e3.
Gohlke H, Illig T, Klopp N, et al. Association study between the D10S1423 microsatellite marker and Alzheimer's disease. Neurobiol Aging. 2006;27(5):776.e1-776.e3.
Gohlke, H., Illig, T., Klopp, N., Wagenpfeil, S., Konta, L., Laws, S. M., Kurz, A., & Riemenschneider, M. (2006). Association study between the D10S1423 microsatellite marker and Alzheimer's disease. Neurobiology of Aging, 27(5), e1-e3.
Gohlke H, et al. Association Study Between the D10S1423 Microsatellite Marker and Alzheimer's Disease. Neurobiol Aging. 2006;27(5):776.e1-776.e3. PubMed PMID: 16026902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association study between the D10S1423 microsatellite marker and Alzheimer's disease. AU - Gohlke,H, AU - Illig,T, AU - Klopp,N, AU - Wagenpfeil,S, AU - Konta,L, AU - Laws,S M, AU - Kurz,A, AU - Riemenschneider,M, Y1 - 2005/07/18/ PY - 2004/03/05/received PY - 2005/02/25/revised PY - 2005/02/25/accepted PY - 2005/7/20/pubmed PY - 2006/5/24/medline PY - 2005/7/20/entrez SP - 776.e1 EP - 776.e3 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 27 IS - 5 N2 - Several studies have reported conflicting results concerning the genetic association between Alzheimer's disease (AD) and the microsatellite marker D10S1423 on chromosome 10p12-14. In an ethnically homogeneous German population of 422 patients with AD and 254 cognitively healthy controls, the 238-bp allele of the D10S1423 marker showed a weak, but after correction for multiple testing no longer significant association with AD (p = 0.015, uncorrected; p = 0.11, corrected). These findings do not support the presence of a relevant susceptibility locus for AD on chromosome 10p12-14. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/16026902/Association_study_between_the_D10S1423_microsatellite_marker_and_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(05)00164-8 DB - PRIME DP - Unbound Medicine ER -