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[Value of plasma brain natriuretic peptide detection in cardiac function assessment in hemodialysis patients].
Di Yi Jun Yi Da Xue Xue Bao. 2005 Jul; 25(7):892-4.DY

Abstract

OBJECTIVE

To detect plasma brain natriuretic peptide (BNP) changes in hemodialysis patients with chronic renal failure (CRF) and assess the diagnostic value of BNP for cardiac function.

METHODS

Plasma BNP concentration was measured in 93 hemodialysis patients with CRF and 52 healthy control subjects. In the 93 patients, echocardiographic examinations were performed to determine the relationship between BNP and cardiac function.

RESULTS

The median plasma BNP levels in 52 normal controls were 3.35 pg/ml (1.00-9.73 pg/ml), and 146.5 pg/ml (56.2-546.9 pg/ml) and 90.0 pg/ml (18.3-310.5 pg/ml) in 93 patients before and after hemodialysis, respectively, showing significant difference among those 3 groups (P<0.001). The plasma BNP levels in patients with CRF complicated by heart failure (LVEF<50%) before and after hemodialysis were 686.0 pg/ml (334.5-1319.3 pg/ml) and 248.0 pg/ml (80.3-814.5 pg/ml) respectively, significantly higher than 62.8 pg/ml (22.0-321.6 pg/ml) and 20.7 pg/ml (1.0-200.9 pg/ml) in patients with normal cardiac function (LVEF > or = 50%) (P=0.002). The plasma BNP levels in patients with dilated left ventricle before and after hemodialysis were 609.0 pg/ml (254-1152.0 pg/ml) and 310.0 pg/ml (28.3-839.6 pg/ml) respectively, significantly higher than 62.8 pg/ml (23.2-192.5 pg/ml) and 22.4 pg/ml (1.0-80.7 pg/ml) in patients with normal left ventricle. Multiple linear regression analysis for left ventricular diastolic dimension, LVEF and plasma BNP level before hemodialysis showed that high BNP level was significantly correlated with dilated left ventricle and poor cardiac function (P<0.01).

CONCLUSIONS

Plasma BNP levels in hemodialysis patients with CRF are significantly higher than those in healthy controls, and are significantly lowered after hemodialysis but still remain higher than the normal level. Plasma BNP levels in hemodialysis patients with dilated left ventricle or heart failure are significantly higher than those in patients with normal left ventricle or cardiac function, and high plasma BNP level is significantly correlated with dilated left ventricle and poor cardiac function.

Authors+Show Affiliations

Department of Nephrology, First People's Hospital of Foshan City, Foshan 528000, China. syhong@fsyyy.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16027094

Citation

Shao, Yong-hong, et al. "[Value of Plasma Brain Natriuretic Peptide Detection in Cardiac Function Assessment in Hemodialysis Patients]." Di 1 Jun Yi Da Xue Xue Bao = Academic Journal of the First Medical College of PLA, vol. 25, no. 7, 2005, pp. 892-4.
Shao YH, Lai YQ, Lin AZ, et al. [Value of plasma brain natriuretic peptide detection in cardiac function assessment in hemodialysis patients]. Di Yi Jun Yi Da Xue Xue Bao. 2005;25(7):892-4.
Shao, Y. H., Lai, Y. Q., Lin, A. Z., & Kong, Y. Z. (2005). [Value of plasma brain natriuretic peptide detection in cardiac function assessment in hemodialysis patients]. Di 1 Jun Yi Da Xue Xue Bao = Academic Journal of the First Medical College of PLA, 25(7), 892-4.
Shao YH, et al. [Value of Plasma Brain Natriuretic Peptide Detection in Cardiac Function Assessment in Hemodialysis Patients]. Di Yi Jun Yi Da Xue Xue Bao. 2005;25(7):892-4. PubMed PMID: 16027094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Value of plasma brain natriuretic peptide detection in cardiac function assessment in hemodialysis patients]. AU - Shao,Yong-hong, AU - Lai,Yu-qiong, AU - Lin,Ai-zhen, AU - Kong,Yao-zhong, PY - 2005/7/20/pubmed PY - 2006/12/9/medline PY - 2005/7/20/entrez SP - 892 EP - 4 JF - Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA JO - Di Yi Jun Yi Da Xue Xue Bao VL - 25 IS - 7 N2 - OBJECTIVE: To detect plasma brain natriuretic peptide (BNP) changes in hemodialysis patients with chronic renal failure (CRF) and assess the diagnostic value of BNP for cardiac function. METHODS: Plasma BNP concentration was measured in 93 hemodialysis patients with CRF and 52 healthy control subjects. In the 93 patients, echocardiographic examinations were performed to determine the relationship between BNP and cardiac function. RESULTS: The median plasma BNP levels in 52 normal controls were 3.35 pg/ml (1.00-9.73 pg/ml), and 146.5 pg/ml (56.2-546.9 pg/ml) and 90.0 pg/ml (18.3-310.5 pg/ml) in 93 patients before and after hemodialysis, respectively, showing significant difference among those 3 groups (P<0.001). The plasma BNP levels in patients with CRF complicated by heart failure (LVEF<50%) before and after hemodialysis were 686.0 pg/ml (334.5-1319.3 pg/ml) and 248.0 pg/ml (80.3-814.5 pg/ml) respectively, significantly higher than 62.8 pg/ml (22.0-321.6 pg/ml) and 20.7 pg/ml (1.0-200.9 pg/ml) in patients with normal cardiac function (LVEF > or = 50%) (P=0.002). The plasma BNP levels in patients with dilated left ventricle before and after hemodialysis were 609.0 pg/ml (254-1152.0 pg/ml) and 310.0 pg/ml (28.3-839.6 pg/ml) respectively, significantly higher than 62.8 pg/ml (23.2-192.5 pg/ml) and 22.4 pg/ml (1.0-80.7 pg/ml) in patients with normal left ventricle. Multiple linear regression analysis for left ventricular diastolic dimension, LVEF and plasma BNP level before hemodialysis showed that high BNP level was significantly correlated with dilated left ventricle and poor cardiac function (P<0.01). CONCLUSIONS: Plasma BNP levels in hemodialysis patients with CRF are significantly higher than those in healthy controls, and are significantly lowered after hemodialysis but still remain higher than the normal level. Plasma BNP levels in hemodialysis patients with dilated left ventricle or heart failure are significantly higher than those in patients with normal left ventricle or cardiac function, and high plasma BNP level is significantly correlated with dilated left ventricle and poor cardiac function. SN - 1000-2588 UR - https://www.unboundmedicine.com/medline/citation/16027094/[Value_of_plasma_brain_natriuretic_peptide_detection_in_cardiac_function_assessment_in_hemodialysis_patients]_ L2 - https://medlineplus.gov/kidneyfailure.html DB - PRIME DP - Unbound Medicine ER -