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Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells.
J Agric Food Chem. 2005 Jul 27; 53(15):6105-11.JA

Abstract

The effects of apple polyphenols on melanogenesis in B16 mouse melanoma cells were investigated. The inhibitory effect of apple polyphenols was stronger than that of arbutin or kojic acid. Three polyphenol fractions (phenolic acid derivatives, procyanidins and other flavonoids) were isolated, and the procyanidins were fractionated according to the degree of polymerization using normal-phase chromatography. The procyanidin trimer-to-pentamer fractions were found to have the most pronounced effect on melanogenesis. Furthermore, each procyanidin fraction inhibited mushroom tyrosinase. No correlation between the degree of procyanidin polymerization and tyrosinase inhibitory activity was observed. Nevertheless, these observations suggest that procyanidins are effective inhibitors of tyrosinase.

Authors+Show Affiliations

Fundamental Research Laboratory, Asahi Breweries, Ltd., 1-21 Midori 1-chome, Moriya, Ibaraki 302-0106, Japan. toshihiko.shoji@asahibeer.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16029003

Citation

Shoji, Toshihiko, et al. "Procyanidin Trimers to Pentamers Fractionated From Apple Inhibit Melanogenesis in B16 Mouse Melanoma Cells." Journal of Agricultural and Food Chemistry, vol. 53, no. 15, 2005, pp. 6105-11.
Shoji T, Masumoto S, Moriichi N, et al. Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells. J Agric Food Chem. 2005;53(15):6105-11.
Shoji, T., Masumoto, S., Moriichi, N., Kobori, M., Kanda, T., Shinmoto, H., & Tsushida, T. (2005). Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells. Journal of Agricultural and Food Chemistry, 53(15), 6105-11.
Shoji T, et al. Procyanidin Trimers to Pentamers Fractionated From Apple Inhibit Melanogenesis in B16 Mouse Melanoma Cells. J Agric Food Chem. 2005 Jul 27;53(15):6105-11. PubMed PMID: 16029003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells. AU - Shoji,Toshihiko, AU - Masumoto,Saeko, AU - Moriichi,Nina, AU - Kobori,Masuko, AU - Kanda,Tomomasa, AU - Shinmoto,Hiroshi, AU - Tsushida,Tojiro, PY - 2005/7/21/pubmed PY - 2005/9/2/medline PY - 2005/7/21/entrez SP - 6105 EP - 11 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 53 IS - 15 N2 - The effects of apple polyphenols on melanogenesis in B16 mouse melanoma cells were investigated. The inhibitory effect of apple polyphenols was stronger than that of arbutin or kojic acid. Three polyphenol fractions (phenolic acid derivatives, procyanidins and other flavonoids) were isolated, and the procyanidins were fractionated according to the degree of polymerization using normal-phase chromatography. The procyanidin trimer-to-pentamer fractions were found to have the most pronounced effect on melanogenesis. Furthermore, each procyanidin fraction inhibited mushroom tyrosinase. No correlation between the degree of procyanidin polymerization and tyrosinase inhibitory activity was observed. Nevertheless, these observations suggest that procyanidins are effective inhibitors of tyrosinase. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/16029003/Procyanidin_trimers_to_pentamers_fractionated_from_apple_inhibit_melanogenesis_in_B16_mouse_melanoma_cells_ L2 - https://doi.org/10.1021/jf050418m DB - PRIME DP - Unbound Medicine ER -