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The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain.
Eur J Neurosci. 2005 Jul; 22(1):278-82.EJ

Abstract

The present study addresses the neuroprotective function of intracerebroventricular (i.c.v.) application of pioglitazone, a selective ligand of the peroxisome proliferator-activated receptor gamma (PPARgamma) in the rat brain after ischaemia. Pioglitazone or vehicle were i.c.v. infused via osmotic minipumps over a 5-day period before, and 2 days after transient middle cerebral artery occlusion (MCAO) for 90 min. This i.c.v. application of pioglitazone in the brain significantly reduced the infarct size and brain oedema, and attenuated in the peri-infarct cortical regions the invasion of activated microglia and macrophages. Moreover, pioglitazone improved the recovery of sensory deficits 48 h after MCAO. Our data demonstrate for the first time that it is the activation of intracerebral PPARgamma that can confer neuroprotection, anti-inflammatory and neurological improvement following ischaemic injury.

Authors+Show Affiliations

Institute of Pharmacology, University Hospital of Schleswig-Holstein, Campus Kiel, Hospitalstrasse 4, 24105 Kiel, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16029218

Citation

Zhao, Yi, et al. "The Intracerebral Application of the PPARgamma-ligand Pioglitazone Confers Neuroprotection Against Focal Ischaemia in the Rat Brain." The European Journal of Neuroscience, vol. 22, no. 1, 2005, pp. 278-82.
Zhao Y, Patzer A, Gohlke P, et al. The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain. Eur J Neurosci. 2005;22(1):278-82.
Zhao, Y., Patzer, A., Gohlke, P., Herdegen, T., & Culman, J. (2005). The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain. The European Journal of Neuroscience, 22(1), 278-82.
Zhao Y, et al. The Intracerebral Application of the PPARgamma-ligand Pioglitazone Confers Neuroprotection Against Focal Ischaemia in the Rat Brain. Eur J Neurosci. 2005;22(1):278-82. PubMed PMID: 16029218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain. AU - Zhao,Yi, AU - Patzer,Andreas, AU - Gohlke,Peter, AU - Herdegen,Thomas, AU - Culman,Juraj, PY - 2005/7/21/pubmed PY - 2005/9/20/medline PY - 2005/7/21/entrez SP - 278 EP - 82 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 22 IS - 1 N2 - The present study addresses the neuroprotective function of intracerebroventricular (i.c.v.) application of pioglitazone, a selective ligand of the peroxisome proliferator-activated receptor gamma (PPARgamma) in the rat brain after ischaemia. Pioglitazone or vehicle were i.c.v. infused via osmotic minipumps over a 5-day period before, and 2 days after transient middle cerebral artery occlusion (MCAO) for 90 min. This i.c.v. application of pioglitazone in the brain significantly reduced the infarct size and brain oedema, and attenuated in the peri-infarct cortical regions the invasion of activated microglia and macrophages. Moreover, pioglitazone improved the recovery of sensory deficits 48 h after MCAO. Our data demonstrate for the first time that it is the activation of intracerebral PPARgamma that can confer neuroprotection, anti-inflammatory and neurological improvement following ischaemic injury. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/16029218/The_intracerebral_application_of_the_PPARgamma_ligand_pioglitazone_confers_neuroprotection_against_focal_ischaemia_in_the_rat_brain_ L2 - https://doi.org/10.1111/j.1460-9568.2005.04200.x DB - PRIME DP - Unbound Medicine ER -