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Risk factors for age-related maculopathy in a 14-year follow-up study: the Copenhagen City Eye Study.
Acta Ophthalmol Scand. 2005 Aug; 83(4):409-18.AO

Abstract

PURPOSE

To examine the association between potential risk factors and the 14-year incidence of age-related maculopathy (ARM).

DESIGN

Population-based cohort study.

PARTICIPANTS

At baseline, 946 volunteers participated in the study during 1986--88. These subjects were between 60 and 80 years of age and lived in the Østerbro district of Copenhagen. Excluding participants who had died since baseline, 359 subjects (97.3% of survivors) were re-examined 14 years later, during 2000--2002. A total of 31.8% (301/946) of the original material was included in the risk factor analyses.

METHODS

Participants underwent an ophthalmological examination at Rigshospitalet, the National University Hospital of Copenhagen. Similar standardized protocols for physical examination were used at the baseline and follow-up examinations. Age-related maculopathy lesions were determined by the same grader grading colour fundus photographs from both examinations using a modification of the Wisconsin Age-related Maculopathy Grading System protocol.

RESULTS

Of the 359 participants, 94 had incident early ARM and 52 had incident late ARM at follow-up in either eye. In logistic regression, the risk factors for early ARM or worse were as follows: cataract (odds ratio [OR] 2.8, 95% confidence interval [CI] 1.2-6.2); family history of ARM (OR 4.5, 95% CI 1.3--15.5), and alcohol consumption >250 g/week (OR 4.6, 95% CI 1.1-19.2). High levels of apolipoprotein B (>100 mg/l) decreased the risk of development of early ARM or worse (OR 0.4, 95% CI 0.2-0.8), while high levels of apolipoprotein A1 (>or= 150 mg/l) increased the risk of late ARM (OR 2.5, 95% CI 1.2-5.3). Advanced age at baseline was also associated with the incidence of late ARM (OR 2.0, 95% CI 1.4-2.9).

CONCLUSIONS

These findings indicate a direct correlation between age, cataract, family history, alcohol consumption, the apolipoproteins A1 and B and the 14-year incidence of ARM.

Authors+Show Affiliations

Department of Ophthalmology, Rigshospitalet, National University Hospital, Copenhagen, Denmark. hbh@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16029262

Citation

Buch, Helena, et al. "Risk Factors for Age-related Maculopathy in a 14-year Follow-up Study: the Copenhagen City Eye Study." Acta Ophthalmologica Scandinavica, vol. 83, no. 4, 2005, pp. 409-18.
Buch H, Vinding T, la Cour M, et al. Risk factors for age-related maculopathy in a 14-year follow-up study: the Copenhagen City Eye Study. Acta Ophthalmol Scand. 2005;83(4):409-18.
Buch, H., Vinding, T., la Cour, M., Jensen, G. B., Prause, J. U., & Nielsen, N. V. (2005). Risk factors for age-related maculopathy in a 14-year follow-up study: the Copenhagen City Eye Study. Acta Ophthalmologica Scandinavica, 83(4), 409-18.
Buch H, et al. Risk Factors for Age-related Maculopathy in a 14-year Follow-up Study: the Copenhagen City Eye Study. Acta Ophthalmol Scand. 2005;83(4):409-18. PubMed PMID: 16029262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for age-related maculopathy in a 14-year follow-up study: the Copenhagen City Eye Study. AU - Buch,Helena, AU - Vinding,Troels, AU - la Cour,Morten, AU - Jensen,Gorm B, AU - Prause,Jan U, AU - Nielsen,Niels V, PY - 2005/7/21/pubmed PY - 2005/9/2/medline PY - 2005/7/21/entrez SP - 409 EP - 18 JF - Acta ophthalmologica Scandinavica JO - Acta Ophthalmol Scand VL - 83 IS - 4 N2 - PURPOSE: To examine the association between potential risk factors and the 14-year incidence of age-related maculopathy (ARM). DESIGN: Population-based cohort study. PARTICIPANTS: At baseline, 946 volunteers participated in the study during 1986--88. These subjects were between 60 and 80 years of age and lived in the Østerbro district of Copenhagen. Excluding participants who had died since baseline, 359 subjects (97.3% of survivors) were re-examined 14 years later, during 2000--2002. A total of 31.8% (301/946) of the original material was included in the risk factor analyses. METHODS: Participants underwent an ophthalmological examination at Rigshospitalet, the National University Hospital of Copenhagen. Similar standardized protocols for physical examination were used at the baseline and follow-up examinations. Age-related maculopathy lesions were determined by the same grader grading colour fundus photographs from both examinations using a modification of the Wisconsin Age-related Maculopathy Grading System protocol. RESULTS: Of the 359 participants, 94 had incident early ARM and 52 had incident late ARM at follow-up in either eye. In logistic regression, the risk factors for early ARM or worse were as follows: cataract (odds ratio [OR] 2.8, 95% confidence interval [CI] 1.2-6.2); family history of ARM (OR 4.5, 95% CI 1.3--15.5), and alcohol consumption >250 g/week (OR 4.6, 95% CI 1.1-19.2). High levels of apolipoprotein B (>100 mg/l) decreased the risk of development of early ARM or worse (OR 0.4, 95% CI 0.2-0.8), while high levels of apolipoprotein A1 (>or= 150 mg/l) increased the risk of late ARM (OR 2.5, 95% CI 1.2-5.3). Advanced age at baseline was also associated with the incidence of late ARM (OR 2.0, 95% CI 1.4-2.9). CONCLUSIONS: These findings indicate a direct correlation between age, cataract, family history, alcohol consumption, the apolipoproteins A1 and B and the 14-year incidence of ARM. SN - 1395-3907 UR - https://www.unboundmedicine.com/medline/citation/16029262/Risk_factors_for_age_related_maculopathy_in_a_14_year_follow_up_study:_the_Copenhagen_City_Eye_Study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1395-3907&date=2005&volume=83&issue=4&spage=409 DB - PRIME DP - Unbound Medicine ER -