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Cigarette smoking and heart rate variability: dynamic influence of parasympathetic and sympathetic maneuvers.
Ann Noninvasive Electrocardiol. 2005 Jul; 10(3):324-9.AN

Abstract

BACKGROUND

Cigarette smoking has been associated with increased activity of the sympathetic nervous system. In this study, we investigated cardiac autonomic function in heavy smokers and nonsmoker controls by analysis of heart rate variability (HRV).

METHOD

Twenty-four long-term heavy smokers (men) and twenty-two nonsmoker subjects (hospital staff) were included to study. Time domain [mean R-R interval (RR), the standard deviation of R-R interval index (SDNN), and the root mean square of successive R-R interval differences (RMSSD)] and frequency domain [high frequency (HF) low frequency (LF), and LF/HF ratio] parameters of HRV were obtained from all participants after 15 minutes resting period in supine position (S), during controlled respiration (CR), and handgrip exercise (HGE) over 5-minute periods.

RESULTS

Baseline SDNN and RMSSD values were found to be lower in smokers than in nonsmokers. (64+/-10 vs 78+/-22, P<0.05 and 35+/-12 vs 54+/-30 ms, P<0.05). Baseline LF/HF ratio was also found to be higher in smokers than in nonsmokers (1.3+/-0.6 vs 0.9+/-0.5 ms, P<0.05). The other HRV parameters including R-R interval, LF, and HF were not significantly different. During CR, expected increase in RR, SDNN, and RMSSD did not occur in smokers, while it did occur in nonsmokers. Most HRV indices were significantly affected by HGE in both groups. In addition, the duration of smoking was found to be inversely correlated with RMSSD and HF and positively correlated with LF/HF ratio.

CONCLUSION

Vagal modulation of the heart is blunted in heavy smokers, particularly during a parasympathetic maneuver. Blunted autonomic control of the heart may partly be associated with adverse event attributed to cigarette smoking.

Authors+Show Affiliations

Department of Cardiology, Kosuyolu Heart Education and Research Hospital, Istanbul, Turkey. irfanbarutcu@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16029383

Citation

Barutcu, Irfan, et al. "Cigarette Smoking and Heart Rate Variability: Dynamic Influence of Parasympathetic and Sympathetic Maneuvers." Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, vol. 10, no. 3, 2005, pp. 324-9.
Barutcu I, Esen AM, Kaya D, et al. Cigarette smoking and heart rate variability: dynamic influence of parasympathetic and sympathetic maneuvers. Ann Noninvasive Electrocardiol. 2005;10(3):324-9.
Barutcu, I., Esen, A. M., Kaya, D., Turkmen, M., Karakaya, O., Melek, M., Esen, O. B., & Basaran, Y. (2005). Cigarette smoking and heart rate variability: dynamic influence of parasympathetic and sympathetic maneuvers. Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 10(3), 324-9.
Barutcu I, et al. Cigarette Smoking and Heart Rate Variability: Dynamic Influence of Parasympathetic and Sympathetic Maneuvers. Ann Noninvasive Electrocardiol. 2005;10(3):324-9. PubMed PMID: 16029383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking and heart rate variability: dynamic influence of parasympathetic and sympathetic maneuvers. AU - Barutcu,Irfan, AU - Esen,Ali Metin, AU - Kaya,Dayimi, AU - Turkmen,Muhsin, AU - Karakaya,Osman, AU - Melek,Mehmet, AU - Esen,Ozlem Batukan, AU - Basaran,Yelda, PY - 2005/7/21/pubmed PY - 2005/11/11/medline PY - 2005/7/21/entrez SP - 324 EP - 9 JF - Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc JO - Ann Noninvasive Electrocardiol VL - 10 IS - 3 N2 - BACKGROUND: Cigarette smoking has been associated with increased activity of the sympathetic nervous system. In this study, we investigated cardiac autonomic function in heavy smokers and nonsmoker controls by analysis of heart rate variability (HRV). METHOD: Twenty-four long-term heavy smokers (men) and twenty-two nonsmoker subjects (hospital staff) were included to study. Time domain [mean R-R interval (RR), the standard deviation of R-R interval index (SDNN), and the root mean square of successive R-R interval differences (RMSSD)] and frequency domain [high frequency (HF) low frequency (LF), and LF/HF ratio] parameters of HRV were obtained from all participants after 15 minutes resting period in supine position (S), during controlled respiration (CR), and handgrip exercise (HGE) over 5-minute periods. RESULTS: Baseline SDNN and RMSSD values were found to be lower in smokers than in nonsmokers. (64+/-10 vs 78+/-22, P<0.05 and 35+/-12 vs 54+/-30 ms, P<0.05). Baseline LF/HF ratio was also found to be higher in smokers than in nonsmokers (1.3+/-0.6 vs 0.9+/-0.5 ms, P<0.05). The other HRV parameters including R-R interval, LF, and HF were not significantly different. During CR, expected increase in RR, SDNN, and RMSSD did not occur in smokers, while it did occur in nonsmokers. Most HRV indices were significantly affected by HGE in both groups. In addition, the duration of smoking was found to be inversely correlated with RMSSD and HF and positively correlated with LF/HF ratio. CONCLUSION: Vagal modulation of the heart is blunted in heavy smokers, particularly during a parasympathetic maneuver. Blunted autonomic control of the heart may partly be associated with adverse event attributed to cigarette smoking. SN - 1082-720X UR - https://www.unboundmedicine.com/medline/citation/16029383/Cigarette_smoking_and_heart_rate_variability:_dynamic_influence_of_parasympathetic_and_sympathetic_maneuvers_ L2 - https://doi.org/10.1111/j.1542-474X.2005.00636.x DB - PRIME DP - Unbound Medicine ER -