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Total cholesterol and body mass index in relation to 40-year cancer mortality (the Corfu cohort of the seven countries study).
Cancer Epidemiol Biomarkers Prev. 2005 Jul; 14(7):1797-801.CE

Abstract

PURPOSE

We evaluated risk factors of cancer mortality based on a 40-year follow-up of the Corfu cohort (Seven Countries Study).

MATERIAL AND METHODS

The population studied in this analysis consisted of 529 rural men (49 +/- 6 years old) enrolled in 1961. Since then, periodic visits every 5 years were made to define the causes of death of the participants. Cox proportional hazards models evaluated various risk factors in relation to cancer mortality.

RESULTS

The death rate at the end of the follow-up was 87.1% (i.e., 461 deaths in 529 participants). Of those deaths, 118 (25.6%) were because of cancer (30 deaths were due to cancer of trachea, bronchus, and lung, and the rest were due to other malignant neoplasms). Cancer was the second cause of death in this cohort, after coronary heart disease. Age (hazard ratio, 1.05 per year; P < 0.05), smoking (hazard ratio, 1.97; P < 0.01), total serum cholesterol levels (hazard ratio, 0.95 per 10 mg/dL; P < 0.05), and body mass index (hazard ratio, 0.93 per 1 kg/m2; P < 0.05) showed a significant association with cancer deaths after controlling for physical activity status and anthropometric indices. It should be noted that the protective effect of total cholesterol on cancer mortality was observed only between 183 and 218 mg/dL baseline levels.

CONCLUSION

Cancer was one of the leading causes of death in this cohort. Smoking was associated with increased risk of cancer, whereas moderate total serum cholesterol and increased body and mass index seemed to have a protective effect on 40-year cancer mortality.

Authors+Show Affiliations

Panagiotakos DB
Department of Dietetics-Nutrition, Harokopio University, 46 Paleon Polemiston Street, Glyfada 16674, Greece. d.b.panagiotakos@usa.net.
Pitsavos C
No affiliation info available
Polychronopoulos E
No affiliation info available
Chrysohoou C
No affiliation info available
Menotti A
No affiliation info available
Dontas A
No affiliation info available
Stefanadis C
No affiliation info available

MeSH

AdultBody Mass IndexCholesterolCohort StudiesExerciseGreeceHumansMaleMiddle AgedNeoplasmsPopulation SurveillanceRisk FactorsSmoking

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16030119

Citation

Panagiotakos, Demosthenes B., et al. "Total Cholesterol and Body Mass Index in Relation to 40-year Cancer Mortality (the Corfu Cohort of the Seven Countries Study)." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 7, 2005, pp. 1797-801.
Panagiotakos DB, Pitsavos C, Polychronopoulos E, et al. Total cholesterol and body mass index in relation to 40-year cancer mortality (the Corfu cohort of the seven countries study). Cancer Epidemiol Biomarkers Prev. 2005;14(7):1797-801.
Panagiotakos, D. B., Pitsavos, C., Polychronopoulos, E., Chrysohoou, C., Menotti, A., Dontas, A., & Stefanadis, C. (2005). Total cholesterol and body mass index in relation to 40-year cancer mortality (the Corfu cohort of the seven countries study). Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(7), 1797-801.
Panagiotakos DB, et al. Total Cholesterol and Body Mass Index in Relation to 40-year Cancer Mortality (the Corfu Cohort of the Seven Countries Study). Cancer Epidemiol Biomarkers Prev. 2005;14(7):1797-801. PubMed PMID: 16030119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Total cholesterol and body mass index in relation to 40-year cancer mortality (the Corfu cohort of the seven countries study). AU - Panagiotakos,Demosthenes B, AU - Pitsavos,Christos, AU - Polychronopoulos,Evangelos, AU - Chrysohoou,Christina, AU - Menotti,Alessandro, AU - Dontas,Anastasios, AU - Stefanadis,Christodoulos, PY - 2005/7/21/pubmed PY - 2005/10/13/medline PY - 2005/7/21/entrez SP - 1797 EP - 801 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 14 IS - 7 N2 - PURPOSE: We evaluated risk factors of cancer mortality based on a 40-year follow-up of the Corfu cohort (Seven Countries Study). MATERIAL AND METHODS: The population studied in this analysis consisted of 529 rural men (49 +/- 6 years old) enrolled in 1961. Since then, periodic visits every 5 years were made to define the causes of death of the participants. Cox proportional hazards models evaluated various risk factors in relation to cancer mortality. RESULTS: The death rate at the end of the follow-up was 87.1% (i.e., 461 deaths in 529 participants). Of those deaths, 118 (25.6%) were because of cancer (30 deaths were due to cancer of trachea, bronchus, and lung, and the rest were due to other malignant neoplasms). Cancer was the second cause of death in this cohort, after coronary heart disease. Age (hazard ratio, 1.05 per year; P < 0.05), smoking (hazard ratio, 1.97; P < 0.01), total serum cholesterol levels (hazard ratio, 0.95 per 10 mg/dL; P < 0.05), and body mass index (hazard ratio, 0.93 per 1 kg/m2; P < 0.05) showed a significant association with cancer deaths after controlling for physical activity status and anthropometric indices. It should be noted that the protective effect of total cholesterol on cancer mortality was observed only between 183 and 218 mg/dL baseline levels. CONCLUSION: Cancer was one of the leading causes of death in this cohort. Smoking was associated with increased risk of cancer, whereas moderate total serum cholesterol and increased body and mass index seemed to have a protective effect on 40-year cancer mortality. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16030119/Total_cholesterol_and_body_mass_index_in_relation_to_40_year_cancer_mortality__the_Corfu_cohort_of_the_seven_countries_study__ DB - PRIME DP - Unbound Medicine ER -