Tags

Type your tag names separated by a space and hit enter

Short-term effects of carbendazim on the gross and microscopic features of the testes of Japanese quails (Coturnix coturnix japonica).
Anat Embryol (Berl). 2005 Aug; 210(1):43-9.AE

Abstract

Carbendazim, a metabolite of benomyl which is widely used as a fungicide, has been found to cause testicular and epididymal damage in laboratory rats, mice and hamsters. No studies of the effects of this chemical on the reproductive organs of birds have been reported previously. This report is that of an investigation on the response of the testis of the Japanese quail to experimental administration of this chemical in sexually mature and active birds. A single dose (400 mg/kg body weight) of carbendazim was administered orally to 20 quails that were sacrificed thereafter at 5 h, 3, 8 and 13 days post-exposure, at five birds spatio-temporally. Five birds acted as control. Testis weights and seminiferous tubular diameter as well as epithelial height decreased significantly from 8 day post-exposure. Epithelial histology was remarkably disrupted, and cessation of spermatogenesis occurred at 13 day post-administration of the chemical. Degenerative changes were uniform in each testis, and not patchy or multi-focal, as previously reported in the rat. The observed histological changes in the testis, due to carbendazim, were capable of causing prolonged infertility in exposed birds.

Authors+Show Affiliations

Department of Anatomy and Physiology, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110, Republic of South Africa. tom.aire@up.ac.za

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16034611

Citation

Aire, T A.. "Short-term Effects of Carbendazim On the Gross and Microscopic Features of the Testes of Japanese Quails (Coturnix Coturnix Japonica)." Anatomy and Embryology, vol. 210, no. 1, 2005, pp. 43-9.
Aire TA. Short-term effects of carbendazim on the gross and microscopic features of the testes of Japanese quails (Coturnix coturnix japonica). Anat Embryol. 2005;210(1):43-9.
Aire, T. A. (2005). Short-term effects of carbendazim on the gross and microscopic features of the testes of Japanese quails (Coturnix coturnix japonica). Anatomy and Embryology, 210(1), 43-9.
Aire TA. Short-term Effects of Carbendazim On the Gross and Microscopic Features of the Testes of Japanese Quails (Coturnix Coturnix Japonica). Anat Embryol. 2005;210(1):43-9. PubMed PMID: 16034611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term effects of carbendazim on the gross and microscopic features of the testes of Japanese quails (Coturnix coturnix japonica). A1 - Aire,T A, Y1 - 2005/07/21/ PY - 2005/04/05/accepted PY - 2005/7/22/pubmed PY - 2005/11/15/medline PY - 2005/7/22/entrez SP - 43 EP - 9 JF - Anatomy and embryology JO - Anat. Embryol. VL - 210 IS - 1 N2 - Carbendazim, a metabolite of benomyl which is widely used as a fungicide, has been found to cause testicular and epididymal damage in laboratory rats, mice and hamsters. No studies of the effects of this chemical on the reproductive organs of birds have been reported previously. This report is that of an investigation on the response of the testis of the Japanese quail to experimental administration of this chemical in sexually mature and active birds. A single dose (400 mg/kg body weight) of carbendazim was administered orally to 20 quails that were sacrificed thereafter at 5 h, 3, 8 and 13 days post-exposure, at five birds spatio-temporally. Five birds acted as control. Testis weights and seminiferous tubular diameter as well as epithelial height decreased significantly from 8 day post-exposure. Epithelial histology was remarkably disrupted, and cessation of spermatogenesis occurred at 13 day post-administration of the chemical. Degenerative changes were uniform in each testis, and not patchy or multi-focal, as previously reported in the rat. The observed histological changes in the testis, due to carbendazim, were capable of causing prolonged infertility in exposed birds. SN - 0340-2061 UR - https://www.unboundmedicine.com/medline/citation/16034611/Short_term_effects_of_carbendazim_on_the_gross_and_microscopic_features_of_the_testes_of_Japanese_quails__Coturnix_coturnix_japonica__ L2 - https://dx.doi.org/10.1007/s00429-005-0001-0 DB - PRIME DP - Unbound Medicine ER -