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Clinical and biochemical characterization of women with polycystic ovary syndrome in North Rhine-Westphalia.

Abstract

Polycystic ovary syndrome (PCOS), defined as the combination of oligoanovulation and hyperandrogenism, affects more than 5% of women of reproductive age. Insulin resistance and hyperinsulinemia appear to play an important role in its pathogenesis. Here, we will present a characterization of a PCOS cohort from North Rhine-Westphalia in Germany. Clinical features, family history as well as endocrine and metabolic parameters were prospectively recorded from 200 successive patients. All patients were evaluated for insulin resistance and beta-cell-function by oral glucose tolerance test. Patient data were compared with those of 98 age-matched control women. PCOS patients showed significantly higher BMI, body fat mass and androgen levels as well as impaired glucose and insulin metabolism. A positive family history of PCOS and diabetes was more frequent in PCOS patients. Insulin resistance (71%) was the most common metabolic abnormality in PCOS patients followed by obesity (52%) and dyslipidemia (46.3%), with an incidence of 31.5% for the metabolic syndrome. C-reactive protein and other cardiovascular risk factors were frequently elevated even in young PCOS patients. While the clinical characteristics and endocrine parameters of this German PCOS cohort were heterogeneous, they were comparable to those from other Caucasian populations.

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  • Authors+Show Affiliations

    ,

    Div. of Endocrinology, Dept. of Medicine, University of Duisburg and Essen, 45122 Essen, Germany.

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    MeSH

    Adult
    Blood Chemical Analysis
    Body Mass Index
    Diabetes Mellitus, Type 2
    Female
    Germany
    Hormones
    Humans
    Hyperandrogenism
    Inflammation
    Polycystic Ovary Syndrome

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16034717

    Citation

    Hahn, S, et al. "Clinical and Biochemical Characterization of Women With Polycystic Ovary Syndrome in North Rhine-Westphalia." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 37, no. 7, 2005, pp. 438-44.
    Hahn S, Tan S, Elsenbruch S, et al. Clinical and biochemical characterization of women with polycystic ovary syndrome in North Rhine-Westphalia. Horm Metab Res. 2005;37(7):438-44.
    Hahn, S., Tan, S., Elsenbruch, S., Quadbeck, B., Herrmann, B. L., Mann, K., & Janssen, O. E. (2005). Clinical and biochemical characterization of women with polycystic ovary syndrome in North Rhine-Westphalia. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 37(7), pp. 438-44.
    Hahn S, et al. Clinical and Biochemical Characterization of Women With Polycystic Ovary Syndrome in North Rhine-Westphalia. Horm Metab Res. 2005;37(7):438-44. PubMed PMID: 16034717.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Clinical and biochemical characterization of women with polycystic ovary syndrome in North Rhine-Westphalia. AU - Hahn,S, AU - Tan,S, AU - Elsenbruch,S, AU - Quadbeck,B, AU - Herrmann,B L, AU - Mann,K, AU - Janssen,O E, PY - 2005/7/22/pubmed PY - 2005/9/28/medline PY - 2005/7/22/entrez SP - 438 EP - 44 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 37 IS - 7 N2 - Polycystic ovary syndrome (PCOS), defined as the combination of oligoanovulation and hyperandrogenism, affects more than 5% of women of reproductive age. Insulin resistance and hyperinsulinemia appear to play an important role in its pathogenesis. Here, we will present a characterization of a PCOS cohort from North Rhine-Westphalia in Germany. Clinical features, family history as well as endocrine and metabolic parameters were prospectively recorded from 200 successive patients. All patients were evaluated for insulin resistance and beta-cell-function by oral glucose tolerance test. Patient data were compared with those of 98 age-matched control women. PCOS patients showed significantly higher BMI, body fat mass and androgen levels as well as impaired glucose and insulin metabolism. A positive family history of PCOS and diabetes was more frequent in PCOS patients. Insulin resistance (71%) was the most common metabolic abnormality in PCOS patients followed by obesity (52%) and dyslipidemia (46.3%), with an incidence of 31.5% for the metabolic syndrome. C-reactive protein and other cardiovascular risk factors were frequently elevated even in young PCOS patients. While the clinical characteristics and endocrine parameters of this German PCOS cohort were heterogeneous, they were comparable to those from other Caucasian populations. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/16034717/full_citation L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2005-870236 DB - PRIME DP - Unbound Medicine ER -