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Fragmentation of oligosaccharide ions with 157 nm vacuum ultraviolet light.
Rapid Commun Mass Spectrom. 2005; 19(16):2313-20.RC

Abstract

The 157 nm photofragmentation of native and derivatized oligosaccharides was studied in a linear ion trap and in a home-built matrix-assisted laser desorption/ionization (MALDI) tandem time-of-flight (TOF/TOF) mass spectrometer, and the results were compared with collision-induced dissociation (CID) experiments. Photodissociation produces product ions corresponding to high-energy fragmentation pathways; for cation-derivatized oligosaccharides, it yields strong cross-ring fragment ions and provides better sequence coverage than low- and high-energy CID experiments. On the other hand, for native oligosaccharides, CID yielded somewhat better sequence coverage than photodissociation. The ion trap enables CID hybrid MS3 experiments on the high-energy fragment ions obtained from photodissociation.

Authors+Show Affiliations

Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16034827

Citation

Devakumar, Arugadoss, et al. "Fragmentation of Oligosaccharide Ions With 157 Nm Vacuum Ultraviolet Light." Rapid Communications in Mass Spectrometry : RCM, vol. 19, no. 16, 2005, pp. 2313-20.
Devakumar A, Thompson MS, Reilly JP. Fragmentation of oligosaccharide ions with 157 nm vacuum ultraviolet light. Rapid Commun Mass Spectrom. 2005;19(16):2313-20.
Devakumar, A., Thompson, M. S., & Reilly, J. P. (2005). Fragmentation of oligosaccharide ions with 157 nm vacuum ultraviolet light. Rapid Communications in Mass Spectrometry : RCM, 19(16), 2313-20.
Devakumar A, Thompson MS, Reilly JP. Fragmentation of Oligosaccharide Ions With 157 Nm Vacuum Ultraviolet Light. Rapid Commun Mass Spectrom. 2005;19(16):2313-20. PubMed PMID: 16034827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fragmentation of oligosaccharide ions with 157 nm vacuum ultraviolet light. AU - Devakumar,Arugadoss, AU - Thompson,Matthew S, AU - Reilly,James P, PY - 2005/7/22/pubmed PY - 2005/9/24/medline PY - 2005/7/22/entrez SP - 2313 EP - 20 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 19 IS - 16 N2 - The 157 nm photofragmentation of native and derivatized oligosaccharides was studied in a linear ion trap and in a home-built matrix-assisted laser desorption/ionization (MALDI) tandem time-of-flight (TOF/TOF) mass spectrometer, and the results were compared with collision-induced dissociation (CID) experiments. Photodissociation produces product ions corresponding to high-energy fragmentation pathways; for cation-derivatized oligosaccharides, it yields strong cross-ring fragment ions and provides better sequence coverage than low- and high-energy CID experiments. On the other hand, for native oligosaccharides, CID yielded somewhat better sequence coverage than photodissociation. The ion trap enables CID hybrid MS3 experiments on the high-energy fragment ions obtained from photodissociation. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/16034827/Fragmentation_of_oligosaccharide_ions_with_157_nm_vacuum_ultraviolet_light_ L2 - https://doi.org/10.1002/rcm.2058 DB - PRIME DP - Unbound Medicine ER -