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Review: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C.
Free Radic Res. 2005 Jul; 39(7):671-86.FR

Abstract

Vitamin C (or ascorbic acid) is regarded as the most important water-soluble antioxidant in human plasma and mammalian cells which have mechanisms to recycle and accumulate it against a concentration gradient, suggesting that the vitamin might also have important intracellular functions. In this review we summarize evidence from human trials that have attempted an association between vitamin C supplementation and an effect on biomarkers of oxidative DNA damage. Most studies reviewed herein showed either a vitamin C-mediated reduction in oxidative DNA damage or a null effect, whereas only a few studies showed an increase in specific base lesions. We also address the possible beneficial effects of vitamin C supplementation for the prevention of cancer and cardiovascular disease. Finally, we discuss the contribution of cell culture studies to our understanding of the mode of action of vitamin C and we review recent evidence that vitamin C is able to modulate gene expression and cellular function, with a particular interest in cell differentiation.

Authors+Show Affiliations

Pharmaceutical Sciences Research Division, Kings College London University.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16036346

Citation

Duarte, Tiago L., and Joseph Lunec. "Review: when Is an Antioxidant Not an Antioxidant? a Review of Novel Actions and Reactions of Vitamin C." Free Radical Research, vol. 39, no. 7, 2005, pp. 671-86.
Duarte TL, Lunec J. Review: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C. Free Radic Res. 2005;39(7):671-86.
Duarte, T. L., & Lunec, J. (2005). Review: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C. Free Radical Research, 39(7), 671-86.
Duarte TL, Lunec J. Review: when Is an Antioxidant Not an Antioxidant? a Review of Novel Actions and Reactions of Vitamin C. Free Radic Res. 2005;39(7):671-86. PubMed PMID: 16036346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Review: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C. AU - Duarte,Tiago L, AU - Lunec,Joseph, PY - 2005/7/23/pubmed PY - 2005/10/26/medline PY - 2005/7/23/entrez SP - 671 EP - 86 JF - Free radical research JO - Free Radic. Res. VL - 39 IS - 7 N2 - Vitamin C (or ascorbic acid) is regarded as the most important water-soluble antioxidant in human plasma and mammalian cells which have mechanisms to recycle and accumulate it against a concentration gradient, suggesting that the vitamin might also have important intracellular functions. In this review we summarize evidence from human trials that have attempted an association between vitamin C supplementation and an effect on biomarkers of oxidative DNA damage. Most studies reviewed herein showed either a vitamin C-mediated reduction in oxidative DNA damage or a null effect, whereas only a few studies showed an increase in specific base lesions. We also address the possible beneficial effects of vitamin C supplementation for the prevention of cancer and cardiovascular disease. Finally, we discuss the contribution of cell culture studies to our understanding of the mode of action of vitamin C and we review recent evidence that vitamin C is able to modulate gene expression and cellular function, with a particular interest in cell differentiation. SN - 1071-5762 UR - https://www.unboundmedicine.com/medline/citation/16036346/Review:_When_is_an_antioxidant_not_an_antioxidant_A_review_of_novel_actions_and_reactions_of_vitamin_C_ L2 - http://www.tandfonline.com/doi/full/10.1080/10715760500104025 DB - PRIME DP - Unbound Medicine ER -