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Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against hydrogen peroxide induced cell damage.
Free Radic Res. 2005 Aug; 39(8):883-92.FR

Abstract

In the present study, triphlorethol-A, a phlorotannin, was isolated from Ecklonia cava and its antioxidant properties were investigated. Triphlorethol-A was found to scavenge intracellular reactive oxygen species (ROS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and thus prevented lipid peroxidation. The radical scavenging activity of triphlorethol-A protected the Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H2O2) against cell death, via the activation of ERK protein. Furthermore, triphlorethol-A reduced the apoptotic cells formation induced by H2O2. Triphlorethol-A increased the activities of cellular antioxidant enzymes like, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Hence, from the present study, it is suggestive that triphlorethol-A protects V79-4 cells against H2O2 damage by enhancing the cellular antioxidative activity.

Authors+Show Affiliations

Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju-si, 690-756, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16036369

Citation

Kang, Kyoung Ah, et al. "Triphlorethol-A From Ecklonia Cava Protects V79-4 Lung Fibroblast Against Hydrogen Peroxide Induced Cell Damage." Free Radical Research, vol. 39, no. 8, 2005, pp. 883-92.
Kang KA, Lee KH, Chae S, et al. Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against hydrogen peroxide induced cell damage. Free Radic Res. 2005;39(8):883-92.
Kang, K. A., Lee, K. H., Chae, S., Koh, Y. S., Yoo, B. S., Kim, J. H., Ham, Y. M., Baik, J. S., Lee, N. H., & Hyun, J. W. (2005). Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against hydrogen peroxide induced cell damage. Free Radical Research, 39(8), 883-92.
Kang KA, et al. Triphlorethol-A From Ecklonia Cava Protects V79-4 Lung Fibroblast Against Hydrogen Peroxide Induced Cell Damage. Free Radic Res. 2005;39(8):883-92. PubMed PMID: 16036369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against hydrogen peroxide induced cell damage. AU - Kang,Kyoung Ah, AU - Lee,Kyoung Hwa, AU - Chae,Sungwook, AU - Koh,Young Sang, AU - Yoo,Byoung-Sam, AU - Kim,Ju Ho, AU - Ham,Young Min, AU - Baik,Jong Seok, AU - Lee,Nam Ho, AU - Hyun,Jin Won, PY - 2005/7/23/pubmed PY - 2005/10/12/medline PY - 2005/7/23/entrez SP - 883 EP - 92 JF - Free radical research JO - Free Radic Res VL - 39 IS - 8 N2 - In the present study, triphlorethol-A, a phlorotannin, was isolated from Ecklonia cava and its antioxidant properties were investigated. Triphlorethol-A was found to scavenge intracellular reactive oxygen species (ROS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and thus prevented lipid peroxidation. The radical scavenging activity of triphlorethol-A protected the Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H2O2) against cell death, via the activation of ERK protein. Furthermore, triphlorethol-A reduced the apoptotic cells formation induced by H2O2. Triphlorethol-A increased the activities of cellular antioxidant enzymes like, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Hence, from the present study, it is suggestive that triphlorethol-A protects V79-4 cells against H2O2 damage by enhancing the cellular antioxidative activity. SN - 1071-5762 UR - https://www.unboundmedicine.com/medline/citation/16036369/Triphlorethol_A_from_Ecklonia_cava_protects_V79_4_lung_fibroblast_against_hydrogen_peroxide_induced_cell_damage_ L2 - https://www.tandfonline.com/doi/full/10.1080/10715760500161165 DB - PRIME DP - Unbound Medicine ER -