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Diet-derived advanced glycation end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects.
Ann N Y Acad Sci 2005; 1043:461-6AN

Abstract

Advanced glycation end products (AGEs) are a heterogeneous group of compounds that form continuously in the body. Their rate of endogenous formation is markedly increased in diabetes mellitus, a condition in which AGEs play a major pathological role. It is also known, however, that AGEs form during the cooking of foods, primarily as the result of the application of heat. This review focuses on the generation of AGEs during the cooking of food, the gastrointestinal absorption of these compounds, and their biological effects in vitro and in vivo. We also present preliminary evidence of a direct association between dietary AGE intake and markers of systemic inflammation such as C-reactive protein in a large group of healthy subjects. Together with previous evidence from diabetics and renal failure patients, these data suggest that dietary AGEs may play an important role in the causation of chronic diseases associated with underlying inflammation.

Authors+Show Affiliations

Division of Nephrology, Deparment of Medicine, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA. jaime.uribarri@mssm.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16037267

Citation

Uribarri, Jaime, et al. "Diet-derived Advanced Glycation End Products Are Major Contributors to the Body's AGE Pool and Induce Inflammation in Healthy Subjects." Annals of the New York Academy of Sciences, vol. 1043, 2005, pp. 461-6.
Uribarri J, Cai W, Sandu O, et al. Diet-derived advanced glycation end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects. Ann N Y Acad Sci. 2005;1043:461-6.
Uribarri, J., Cai, W., Sandu, O., Peppa, M., Goldberg, T., & Vlassara, H. (2005). Diet-derived advanced glycation end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects. Annals of the New York Academy of Sciences, 1043, pp. 461-6.
Uribarri J, et al. Diet-derived Advanced Glycation End Products Are Major Contributors to the Body's AGE Pool and Induce Inflammation in Healthy Subjects. Ann N Y Acad Sci. 2005;1043:461-6. PubMed PMID: 16037267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet-derived advanced glycation end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects. AU - Uribarri,Jaime, AU - Cai,Weijing, AU - Sandu,Oana, AU - Peppa,Melpomeni, AU - Goldberg,Teresia, AU - Vlassara,Helen, PY - 2005/7/23/pubmed PY - 2005/10/28/medline PY - 2005/7/23/entrez SP - 461 EP - 6 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 1043 N2 - Advanced glycation end products (AGEs) are a heterogeneous group of compounds that form continuously in the body. Their rate of endogenous formation is markedly increased in diabetes mellitus, a condition in which AGEs play a major pathological role. It is also known, however, that AGEs form during the cooking of foods, primarily as the result of the application of heat. This review focuses on the generation of AGEs during the cooking of food, the gastrointestinal absorption of these compounds, and their biological effects in vitro and in vivo. We also present preliminary evidence of a direct association between dietary AGE intake and markers of systemic inflammation such as C-reactive protein in a large group of healthy subjects. Together with previous evidence from diabetics and renal failure patients, these data suggest that dietary AGEs may play an important role in the causation of chronic diseases associated with underlying inflammation. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/16037267/Diet_derived_advanced_glycation_end_products_are_major_contributors_to_the_body's_AGE_pool_and_induce_inflammation_in_healthy_subjects_ L2 - https://doi.org/10.1196/annals.1333.052 DB - PRIME DP - Unbound Medicine ER -