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[Mediastinal large B-cell lymphoma with symptomatic superior vena cava syndrome in a patient with bichorial twin pregnancy in the 26th week of gestation: peri-and postpartal management -- a case report].
Zentralbl Gynakol. 2005 Aug; 127(4):248-51.ZG

Abstract

OBJECTIVE

Non-Hodgkin lymphoma (NHL) is rarely observed during pregnancy. The clinical behavior of this malignancy does not differ significantly from that outside of the setting of pregnancy. Antineoplastic chemotherapy is usually given during the second and third trimester. However, irradiation is another therapeutic option. The teratogenic potential limits its use in pregnancy. Finding an appropriate therapeutic management in an emergency setting is therefore difficult.

CASE REPORT

In this report, we describe the case of a 31-year-old gravida three, para two, in whom a mediastinal large B-cell lymphoma with symptomatic superior vena cava syndrome was diagnosed in a bichorial twin pregnancy in the 26 (th) week of gestation. After premature delivery by caesarean section at 26 + 0 weeks gestation the patient was immediately submitted to mediastinal irradiation. The clinical symptoms resolved and adjuvant CHOEP-chemotherapy was instituted. Chemotherapy was well tolerated and a partial remission was observed after 4 cycles. The neonatological follow-up was uneventful.

DISCUSSION

To our knowledge, this is the first case in the literature of a patient with bichorial twin pregnancy with large cell mediastinal NHL and symptomatic superior vena cava syndrome who underwent irradiation after caesarean section because of life-threatening medical condition.

Authors+Show Affiliations

Frauenklinik der Universität Würzburg. adjakovic@gmx.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ger

PubMed ID

16037907

Citation

Djakovic, A, et al. "[Mediastinal Large B-cell Lymphoma With Symptomatic Superior Vena Cava Syndrome in a Patient With Bichorial Twin Pregnancy in the 26th Week of Gestation: Peri-and Postpartal Management -- a Case Report]." Zentralblatt Fur Gynakologie, vol. 127, no. 4, 2005, pp. 248-51.
Djakovic A, Ott G, Zollner U, et al. [Mediastinal large B-cell lymphoma with symptomatic superior vena cava syndrome in a patient with bichorial twin pregnancy in the 26th week of gestation: peri-and postpartal management -- a case report]. Zentralbl Gynakol. 2005;127(4):248-51.
Djakovic, A., Ott, G., Zollner, U., Vordermark, D., & Dietl, J. (2005). [Mediastinal large B-cell lymphoma with symptomatic superior vena cava syndrome in a patient with bichorial twin pregnancy in the 26th week of gestation: peri-and postpartal management -- a case report]. Zentralblatt Fur Gynakologie, 127(4), 248-51.
Djakovic A, et al. [Mediastinal Large B-cell Lymphoma With Symptomatic Superior Vena Cava Syndrome in a Patient With Bichorial Twin Pregnancy in the 26th Week of Gestation: Peri-and Postpartal Management -- a Case Report]. Zentralbl Gynakol. 2005;127(4):248-51. PubMed PMID: 16037907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Mediastinal large B-cell lymphoma with symptomatic superior vena cava syndrome in a patient with bichorial twin pregnancy in the 26th week of gestation: peri-and postpartal management -- a case report]. AU - Djakovic,A, AU - Ott,G, AU - Zollner,U, AU - Vordermark,D, AU - Dietl,J, PY - 2005/7/23/pubmed PY - 2005/10/28/medline PY - 2005/7/23/entrez SP - 248 EP - 51 JF - Zentralblatt fur Gynakologie JO - Zentralbl Gynakol VL - 127 IS - 4 N2 - OBJECTIVE: Non-Hodgkin lymphoma (NHL) is rarely observed during pregnancy. The clinical behavior of this malignancy does not differ significantly from that outside of the setting of pregnancy. Antineoplastic chemotherapy is usually given during the second and third trimester. However, irradiation is another therapeutic option. The teratogenic potential limits its use in pregnancy. Finding an appropriate therapeutic management in an emergency setting is therefore difficult. CASE REPORT: In this report, we describe the case of a 31-year-old gravida three, para two, in whom a mediastinal large B-cell lymphoma with symptomatic superior vena cava syndrome was diagnosed in a bichorial twin pregnancy in the 26 (th) week of gestation. After premature delivery by caesarean section at 26 + 0 weeks gestation the patient was immediately submitted to mediastinal irradiation. The clinical symptoms resolved and adjuvant CHOEP-chemotherapy was instituted. Chemotherapy was well tolerated and a partial remission was observed after 4 cycles. The neonatological follow-up was uneventful. DISCUSSION: To our knowledge, this is the first case in the literature of a patient with bichorial twin pregnancy with large cell mediastinal NHL and symptomatic superior vena cava syndrome who underwent irradiation after caesarean section because of life-threatening medical condition. SN - 0044-4197 UR - https://www.unboundmedicine.com/medline/citation/16037907/[Mediastinal_large_B_cell_lymphoma_with_symptomatic_superior_vena_cava_syndrome_in_a_patient_with_bichorial_twin_pregnancy_in_the_26th_week_of_gestation:_peri_and_postpartal_management____a_case_report]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2005-836499 DB - PRIME DP - Unbound Medicine ER -