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Effects of tibolone on body composition in postmenopausal women: a 1-year follow up study.
Maturitas. 2005 Aug 16; 51(4):363-9.M

Abstract

OBJECTIVE

We investigated the effects of 1-year tibolone treatment on body weight, body composition and indices of android obesity in postmenopausal women.

METHODS

Forty-four postmenopausal women participated in this open-label controlled study; mean age was 51.8+/-2.21 years and all women were menopausal for 3.8+/-1.40 years. Twenty-two of them started taking 2.5 mg tibolone (TIB) daily for 1 year, whereas the remaining 22 served as age-matched controls. All subjects underwent a structured interview, physical examination, body composition measurements performed by dual-energy X-ray absorptiometry (DXA) - Hologic QDR 4500 A, as well as bioelectrical body impedance analysis (BI) - Tanita TBF-215, Japan.

RESULTS

The TIB group did not significantly increase their weight (+0.4 kg), while the non-treated controls increased their mean weight by 1.4 kg (p=0.046). In the TIB group, DXA showed a non-significant body fat decrease by a mean of 0.5 kg and a non-significant lean mass increase by 0.8 kg, while in the control group, fat mass increased by 1.7 kg (p=0.032) and lean mass did not change. BI revealed that the TIB group had lost some fat (approximately 0.6 kg, n.s.) and put some free-fat mass (approximately 1.0 kg, p=0.048) without changes in total body water. The control group put on some fat (approximately 1.1 kg, p=0.042) and lost some body water (approximately 0.4 kg, n.s.).

CONCLUSION

Results from both methods of measuring body composition show a similar trend: a decrease in fat mass and an increase in lean mass in TIB treated subjects. From the body composition perspective, tibolone may be regarded as a preferential alternative to conventional hormonal therapy (HT) in postmenopausal women.

Authors+Show Affiliations

Endocrinology Clinic, Alexandrovska Hospital, Medical University of Sofia, 1 G. Sofiiski str., 1431 Sofia, Bulgaria. boyanov@sun.medun.acad.bgNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16039409

Citation

Boyanov, Mihail A., and Alexander D. Shinkov. "Effects of Tibolone On Body Composition in Postmenopausal Women: a 1-year Follow Up Study." Maturitas, vol. 51, no. 4, 2005, pp. 363-9.
Boyanov MA, Shinkov AD. Effects of tibolone on body composition in postmenopausal women: a 1-year follow up study. Maturitas. 2005;51(4):363-9.
Boyanov, M. A., & Shinkov, A. D. (2005). Effects of tibolone on body composition in postmenopausal women: a 1-year follow up study. Maturitas, 51(4), 363-9.
Boyanov MA, Shinkov AD. Effects of Tibolone On Body Composition in Postmenopausal Women: a 1-year Follow Up Study. Maturitas. 2005 Aug 16;51(4):363-9. PubMed PMID: 16039409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of tibolone on body composition in postmenopausal women: a 1-year follow up study. AU - Boyanov,Mihail A, AU - Shinkov,Alexander D, PY - 2004/07/07/received PY - 2004/09/15/revised PY - 2004/09/16/accepted PY - 2005/7/26/pubmed PY - 2006/7/22/medline PY - 2005/7/26/entrez SP - 363 EP - 9 JF - Maturitas JO - Maturitas VL - 51 IS - 4 N2 - OBJECTIVE: We investigated the effects of 1-year tibolone treatment on body weight, body composition and indices of android obesity in postmenopausal women. METHODS: Forty-four postmenopausal women participated in this open-label controlled study; mean age was 51.8+/-2.21 years and all women were menopausal for 3.8+/-1.40 years. Twenty-two of them started taking 2.5 mg tibolone (TIB) daily for 1 year, whereas the remaining 22 served as age-matched controls. All subjects underwent a structured interview, physical examination, body composition measurements performed by dual-energy X-ray absorptiometry (DXA) - Hologic QDR 4500 A, as well as bioelectrical body impedance analysis (BI) - Tanita TBF-215, Japan. RESULTS: The TIB group did not significantly increase their weight (+0.4 kg), while the non-treated controls increased their mean weight by 1.4 kg (p=0.046). In the TIB group, DXA showed a non-significant body fat decrease by a mean of 0.5 kg and a non-significant lean mass increase by 0.8 kg, while in the control group, fat mass increased by 1.7 kg (p=0.032) and lean mass did not change. BI revealed that the TIB group had lost some fat (approximately 0.6 kg, n.s.) and put some free-fat mass (approximately 1.0 kg, p=0.048) without changes in total body water. The control group put on some fat (approximately 1.1 kg, p=0.042) and lost some body water (approximately 0.4 kg, n.s.). CONCLUSION: Results from both methods of measuring body composition show a similar trend: a decrease in fat mass and an increase in lean mass in TIB treated subjects. From the body composition perspective, tibolone may be regarded as a preferential alternative to conventional hormonal therapy (HT) in postmenopausal women. SN - 0378-5122 UR - https://www.unboundmedicine.com/medline/citation/16039409/Effects_of_tibolone_on_body_composition_in_postmenopausal_women:_a_1_year_follow_up_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(04)00319-6 DB - PRIME DP - Unbound Medicine ER -