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The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study.
Biol Psychiatry. 2005 Sep 15; 58(6):457-67.BP

Abstract

BACKGROUND

Region of interest studies have identified a number of structure-cognition associations in schizophrenia and revealed alterations in structure-cognition relationship in this population.

METHODS

We examined the relationship of structural brain alterations, identified using voxel-based morphometry, to cognitive deficits in 45 schizophrenia patients relative to 43 healthy control subjects and tested the hypothesis that structure-cognition relationship is altered in schizophrenia.

RESULTS

Patients had smaller total brain, gray matter, and white matter volumes. Regional alterations were left-hemisphere specific, including: gray matter reduction of inferior frontal, lingual, and anterior superior temporal gyri; white matter reduction of posterior and occipital lobes; and gray matter increase of the putamen and the precuneus. Smaller whole brain and gray matter volumes were associated with lower premorbid intelligence quotient (IQ) and poorer performance on IQ-dependent cognitive measures in patients and to a similar extent in control subjects. Larger precuneus was associated with better immediate verbal memory in patients, whereas verbal and nonverbal memory were positively associated with inferior frontal gyrus volume in control subjects. Smaller occipital white matter volume was associated with slower information processing speed in patients but not in control subjects.

CONCLUSIONS

Regional volume alterations are associated with specific cognitive deficits in schizophrenia. Some structure-cognition relationships differentiate this population from healthy control subjects.

Authors+Show Affiliations

Department of Psychology, Institute of Psychiatry, London, UK. e.antonova@iop.kcl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16039619

Citation

Antonova, Elena, et al. "The Relationship of Structural Alterations to Cognitive Deficits in Schizophrenia: a Voxel-based Morphometry Study." Biological Psychiatry, vol. 58, no. 6, 2005, pp. 457-67.
Antonova E, Kumari V, Morris R, et al. The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study. Biol Psychiatry. 2005;58(6):457-67.
Antonova, E., Kumari, V., Morris, R., Halari, R., Anilkumar, A., Mehrotra, R., & Sharma, T. (2005). The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study. Biological Psychiatry, 58(6), 457-67.
Antonova E, et al. The Relationship of Structural Alterations to Cognitive Deficits in Schizophrenia: a Voxel-based Morphometry Study. Biol Psychiatry. 2005 Sep 15;58(6):457-67. PubMed PMID: 16039619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study. AU - Antonova,Elena, AU - Kumari,Veena, AU - Morris,Robin, AU - Halari,Rozmin, AU - Anilkumar,A, AU - Mehrotra,Ravi, AU - Sharma,Tonmoy, PY - 2004/10/18/received PY - 2005/03/23/revised PY - 2005/04/14/accepted PY - 2005/7/26/pubmed PY - 2005/12/13/medline PY - 2005/7/26/entrez SP - 457 EP - 67 JF - Biological psychiatry JO - Biol. Psychiatry VL - 58 IS - 6 N2 - BACKGROUND: Region of interest studies have identified a number of structure-cognition associations in schizophrenia and revealed alterations in structure-cognition relationship in this population. METHODS: We examined the relationship of structural brain alterations, identified using voxel-based morphometry, to cognitive deficits in 45 schizophrenia patients relative to 43 healthy control subjects and tested the hypothesis that structure-cognition relationship is altered in schizophrenia. RESULTS: Patients had smaller total brain, gray matter, and white matter volumes. Regional alterations were left-hemisphere specific, including: gray matter reduction of inferior frontal, lingual, and anterior superior temporal gyri; white matter reduction of posterior and occipital lobes; and gray matter increase of the putamen and the precuneus. Smaller whole brain and gray matter volumes were associated with lower premorbid intelligence quotient (IQ) and poorer performance on IQ-dependent cognitive measures in patients and to a similar extent in control subjects. Larger precuneus was associated with better immediate verbal memory in patients, whereas verbal and nonverbal memory were positively associated with inferior frontal gyrus volume in control subjects. Smaller occipital white matter volume was associated with slower information processing speed in patients but not in control subjects. CONCLUSIONS: Regional volume alterations are associated with specific cognitive deficits in schizophrenia. Some structure-cognition relationships differentiate this population from healthy control subjects. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/16039619/The_relationship_of_structural_alterations_to_cognitive_deficits_in_schizophrenia:_a_voxel_based_morphometry_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(05)00497-X DB - PRIME DP - Unbound Medicine ER -