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Inactivation of the rat dorsal striatum impairs performance in spatial tasks and alters hippocampal theta in the freely moving rat.
Behav Brain Res. 2005 Oct 14; 164(1):73-82.BB

Abstract

We analysed the interaction between the dorsal striatum (motor coordination and planning) and the hippocampus (sensory information processing and integration) during performance of goal-directed tasks. The performance of rats that had been injected with different doses of the D(2)-antagonist Sulpiride into the dorsal striatum was tested in an egocentric 4-arm maze task that tests striatal functions. Furthermore, hippocampal EEGs were recorded before, during and after inactivation of the dorsal striatum via injections of Sulpiride of rats that were performing a continuous alternation task. Injection of 5 microl of 100 mM Sulpiride increased the number of errors committed in the egocentric 4-arm maze (p < 0.01), indicating that the dorsal striatum is involved in motor control and motor memory recall in such a task. In the recording study, the same dose of Sulpiride injected into the dorsal striatum had powerful effects on the hippocampal EEG. The main activity in the theta range (5-10 Hz) was shifted from higher frequencies in the 8-10 Hz range to lower frequencies in the 5-7 Hz range (p < 0.005). The impairment in the behavioural egocentric task after Sulpiride injection, and the effects of Sulpiride on hippocampal theta shows that there is a functional interaction between the dorsal striatum and the hippocampus. While the dorsal striatum coordinates the execution of complex motor programs, the hippocampus integrates spatial and other sensory information required for the planning and execution of goal-directed movements.

Authors+Show Affiliations

Cognitive Neuroscience, Department of Zoology, University of Tübingen, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16039727

Citation

Gengler, Simon, et al. "Inactivation of the Rat Dorsal Striatum Impairs Performance in Spatial Tasks and Alters Hippocampal Theta in the Freely Moving Rat." Behavioural Brain Research, vol. 164, no. 1, 2005, pp. 73-82.
Gengler S, Mallot HA, Hölscher C. Inactivation of the rat dorsal striatum impairs performance in spatial tasks and alters hippocampal theta in the freely moving rat. Behav Brain Res. 2005;164(1):73-82.
Gengler, S., Mallot, H. A., & Hölscher, C. (2005). Inactivation of the rat dorsal striatum impairs performance in spatial tasks and alters hippocampal theta in the freely moving rat. Behavioural Brain Research, 164(1), 73-82.
Gengler S, Mallot HA, Hölscher C. Inactivation of the Rat Dorsal Striatum Impairs Performance in Spatial Tasks and Alters Hippocampal Theta in the Freely Moving Rat. Behav Brain Res. 2005 Oct 14;164(1):73-82. PubMed PMID: 16039727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inactivation of the rat dorsal striatum impairs performance in spatial tasks and alters hippocampal theta in the freely moving rat. AU - Gengler,Simon, AU - Mallot,Hanspeter A, AU - Hölscher,Christian, PY - 2005/02/15/received PY - 2005/05/31/revised PY - 2005/06/01/accepted PY - 2005/7/26/pubmed PY - 2006/1/21/medline PY - 2005/7/26/entrez SP - 73 EP - 82 JF - Behavioural brain research JO - Behav Brain Res VL - 164 IS - 1 N2 - We analysed the interaction between the dorsal striatum (motor coordination and planning) and the hippocampus (sensory information processing and integration) during performance of goal-directed tasks. The performance of rats that had been injected with different doses of the D(2)-antagonist Sulpiride into the dorsal striatum was tested in an egocentric 4-arm maze task that tests striatal functions. Furthermore, hippocampal EEGs were recorded before, during and after inactivation of the dorsal striatum via injections of Sulpiride of rats that were performing a continuous alternation task. Injection of 5 microl of 100 mM Sulpiride increased the number of errors committed in the egocentric 4-arm maze (p < 0.01), indicating that the dorsal striatum is involved in motor control and motor memory recall in such a task. In the recording study, the same dose of Sulpiride injected into the dorsal striatum had powerful effects on the hippocampal EEG. The main activity in the theta range (5-10 Hz) was shifted from higher frequencies in the 8-10 Hz range to lower frequencies in the 5-7 Hz range (p < 0.005). The impairment in the behavioural egocentric task after Sulpiride injection, and the effects of Sulpiride on hippocampal theta shows that there is a functional interaction between the dorsal striatum and the hippocampus. While the dorsal striatum coordinates the execution of complex motor programs, the hippocampus integrates spatial and other sensory information required for the planning and execution of goal-directed movements. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/16039727/Inactivation_of_the_rat_dorsal_striatum_impairs_performance_in_spatial_tasks_and_alters_hippocampal_theta_in_the_freely_moving_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(05)00223-8 DB - PRIME DP - Unbound Medicine ER -