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Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist.
Pharmacol Biochem Behav. 2005 Aug; 81(4):901-6.PB

Abstract

The involvement of glutamate in the pathophysiology of depression has been suggested by a number of experiments. It was well established that compounds, which decreased glutamatergic transmission via blockade of NMDA receptor, produced antidepressant-like action in animal tests and models. The present study was carried out to investigate whether a selective mGluR5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP) induces antidepressant-like effects after intraperitoneal injections in male Wistar rats or male C57BL/6J mice. Potential antidepressant-like activity of MTEP was evaluated using the forced swimming test (FST) in rats, the tail suspension test (TST) in mice and the olfactory bulbectomy (OB) model of depression in rats. The results of our studies showed, that MTEP (0.3-3 mg/kg) produced a significant dose-dependent decrease in the immobility time of mice in the TST, however, at doses of 1 or 10 mg/kg, it did not influence the behavior of rats in the FST in rats. Moreover, the repeated administration of MTEP (1 mg/kg) attenuated the OB-related hyperactivity of rats in the open field test, in the manner similar to that seen following chronic (but not acute) treatment with typical antidepressant drugs. These data suggest that MTEP, which is considered to be a potential therapeutic agent, may play a role in the therapy of depression.

Authors+Show Affiliations

Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Smetna 12, Poland. nfpaluch@cyf-kr.edu.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16040106

Citation

Pałucha, Agnieszka, et al. "Potential Antidepressant-like Effect of MTEP, a Potent and Highly Selective mGluR5 Antagonist." Pharmacology, Biochemistry, and Behavior, vol. 81, no. 4, 2005, pp. 901-6.
Pałucha A, Brański P, Szewczyk B, et al. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacol Biochem Behav. 2005;81(4):901-6.
Pałucha, A., Brański, P., Szewczyk, B., Wierońska, J. M., Kłak, K., & Pilc, A. (2005). Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacology, Biochemistry, and Behavior, 81(4), 901-6.
Pałucha A, et al. Potential Antidepressant-like Effect of MTEP, a Potent and Highly Selective mGluR5 Antagonist. Pharmacol Biochem Behav. 2005;81(4):901-6. PubMed PMID: 16040106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. AU - Pałucha,Agnieszka, AU - Brański,Piotr, AU - Szewczyk,Bernadeta, AU - Wierońska,Joanna M, AU - Kłak,Kinga, AU - Pilc,Andrzej, PY - 2004/10/22/received PY - 2005/05/31/revised PY - 2005/06/06/accepted PY - 2005/7/26/pubmed PY - 2005/12/13/medline PY - 2005/7/26/entrez SP - 901 EP - 6 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 81 IS - 4 N2 - The involvement of glutamate in the pathophysiology of depression has been suggested by a number of experiments. It was well established that compounds, which decreased glutamatergic transmission via blockade of NMDA receptor, produced antidepressant-like action in animal tests and models. The present study was carried out to investigate whether a selective mGluR5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP) induces antidepressant-like effects after intraperitoneal injections in male Wistar rats or male C57BL/6J mice. Potential antidepressant-like activity of MTEP was evaluated using the forced swimming test (FST) in rats, the tail suspension test (TST) in mice and the olfactory bulbectomy (OB) model of depression in rats. The results of our studies showed, that MTEP (0.3-3 mg/kg) produced a significant dose-dependent decrease in the immobility time of mice in the TST, however, at doses of 1 or 10 mg/kg, it did not influence the behavior of rats in the FST in rats. Moreover, the repeated administration of MTEP (1 mg/kg) attenuated the OB-related hyperactivity of rats in the open field test, in the manner similar to that seen following chronic (but not acute) treatment with typical antidepressant drugs. These data suggest that MTEP, which is considered to be a potential therapeutic agent, may play a role in the therapy of depression. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/16040106/Potential_antidepressant_like_effect_of_MTEP_a_potent_and_highly_selective_mGluR5_antagonist_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(05)00218-2 DB - PRIME DP - Unbound Medicine ER -