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Allele epsilon 4 of APOE is a stronger predictor of Alzheimer risk in Sicily than in continental South Italy.
Neurosci Lett. 2005 Nov 18; 388(3):168-72.NL

Abstract

The genotype of apolipoprotein E was examined in 173 sporadic Alzheimer's disease (AD) patients, 132 with late onset (LOAD) and 41 with early onset (EOAD), and in 174 healthy matched controls from Sicily. Despite a low frequency of the epsilon 4 allele (6.3%, 95% CI: 4.2--9.4) in controls, epsilon 4 allele was a stronger predictor of AD risk (odds ratio: 5.8, 95% CI: 3.5--9.4; p<0.0001) than in most of the studies performed in other regions of Italy, and it has no influence on age at onset. epsilon 4/epsilon 4 and epsilon 4/epsilon 3 genotypes were similar predictors of AD risk. Conversely, a decreased risk was found in epsilon 3 allele carriers (odds ratio: 0.3, 95% CI: 0.2--0.4; p<0.0001), which remained significant when considering EOAD cases only (odds ratio: 0.2, 95% CI: 0.1--0.4, p<0.0001). In conclusion, differences in association strength of epsilon 4 allele with AD between Sicily and other regions of Italy suggest an influence of complex gene-gene and gene-environment interactions.

Authors+Show Affiliations

IRCCS Associazione Oasi Maria S.S. - Institute for Research on Mental Retardation and Brain Aging, 94018 Troina (EN), Enna, Italy. pbosco@oasi.en.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16040191

Citation

Bosco, Paolo, et al. "Allele Epsilon 4 of APOE Is a Stronger Predictor of Alzheimer Risk in Sicily Than in Continental South Italy." Neuroscience Letters, vol. 388, no. 3, 2005, pp. 168-72.
Bosco P, Guéant-Rodríguez RM, Anello G, et al. Allele epsilon 4 of APOE is a stronger predictor of Alzheimer risk in Sicily than in continental South Italy. Neurosci Lett. 2005;388(3):168-72.
Bosco, P., Guéant-Rodríguez, R. M., Anello, G., Spada, R. S., Romano, A., Caraci, F., Ferri, R., & Guéant, J. L. (2005). Allele epsilon 4 of APOE is a stronger predictor of Alzheimer risk in Sicily than in continental South Italy. Neuroscience Letters, 388(3), 168-72.
Bosco P, et al. Allele Epsilon 4 of APOE Is a Stronger Predictor of Alzheimer Risk in Sicily Than in Continental South Italy. Neurosci Lett. 2005 Nov 18;388(3):168-72. PubMed PMID: 16040191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allele epsilon 4 of APOE is a stronger predictor of Alzheimer risk in Sicily than in continental South Italy. AU - Bosco,Paolo, AU - Guéant-Rodríguez,Rosa-Maria, AU - Anello,Guido, AU - Spada,Rosario S, AU - Romano,Antonino, AU - Caraci,Filippo, AU - Ferri,Raffaele, AU - Guéant,Jean-Louis, PY - 2005/05/05/received PY - 2005/06/21/revised PY - 2005/06/27/accepted PY - 2005/7/26/pubmed PY - 2006/1/24/medline PY - 2005/7/26/entrez SP - 168 EP - 72 JF - Neuroscience letters JO - Neurosci. Lett. VL - 388 IS - 3 N2 - The genotype of apolipoprotein E was examined in 173 sporadic Alzheimer's disease (AD) patients, 132 with late onset (LOAD) and 41 with early onset (EOAD), and in 174 healthy matched controls from Sicily. Despite a low frequency of the epsilon 4 allele (6.3%, 95% CI: 4.2--9.4) in controls, epsilon 4 allele was a stronger predictor of AD risk (odds ratio: 5.8, 95% CI: 3.5--9.4; p<0.0001) than in most of the studies performed in other regions of Italy, and it has no influence on age at onset. epsilon 4/epsilon 4 and epsilon 4/epsilon 3 genotypes were similar predictors of AD risk. Conversely, a decreased risk was found in epsilon 3 allele carriers (odds ratio: 0.3, 95% CI: 0.2--0.4; p<0.0001), which remained significant when considering EOAD cases only (odds ratio: 0.2, 95% CI: 0.1--0.4, p<0.0001). In conclusion, differences in association strength of epsilon 4 allele with AD between Sicily and other regions of Italy suggest an influence of complex gene-gene and gene-environment interactions. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/16040191/Allele_epsilon_4_of_APOE_is_a_stronger_predictor_of_Alzheimer_risk_in_Sicily_than_in_continental_South_Italy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(05)00757-3 DB - PRIME DP - Unbound Medicine ER -