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Endothelial function markers in parkinsonian patients with hyperhomocysteinemia.
J Clin Neurosci. 2005 Aug; 12(6):669-72.JC

Abstract

Hyperhomocysteinemia is considered a risk factor for vascular disease causing endothelial damage and consequently atherogenesis. The purpose of this study was to investigate the effect of elevated homocysteine on certain biochemical markers of endothelial function in patients with idiopathic Parkinson's disease (PD). Blood homocysteine levels were assessed in 57 PD patients and 40 matched normal controls. Investigation of the C677T 5,10 methylenetetrahydrofolate reductase (MTHFR) genotype was also performed in 43 PD patients. The following markers of endothelial function were assessed: superoxide dismutase (SOD), nitric oxide (NO), sICAM-1 and sE-selectin. Homocysteine levels were found mildly elevated in PD patients particularly in those treated with L-Dopa. MTHFR genotype did not influence significantly this finding. SOD activity was found reduced but it was not correlated to homocysteine levels. All other parameters measured were normal and were not related to hyperhomocysteinemia. Our findings indicate that mild hyperhomocysteinemia in PD patients was not associated with endothelial dysfunction.

Authors+Show Affiliations

3rd University Dept. of Neurology, Thessaloniki, Greece. bostkamb@spark.net.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16040247

Citation

Bostantjopoulou, Sevasti, et al. "Endothelial Function Markers in Parkinsonian Patients With Hyperhomocysteinemia." Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, vol. 12, no. 6, 2005, pp. 669-72.
Bostantjopoulou S, Katsarou Z, Frangia T, et al. Endothelial function markers in parkinsonian patients with hyperhomocysteinemia. J Clin Neurosci. 2005;12(6):669-72.
Bostantjopoulou, S., Katsarou, Z., Frangia, T., Hatzizisi, O., Papazisis, K., Kyriazis, G., Kiosseoglou, G., & Kazis, A. (2005). Endothelial function markers in parkinsonian patients with hyperhomocysteinemia. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 12(6), 669-72.
Bostantjopoulou S, et al. Endothelial Function Markers in Parkinsonian Patients With Hyperhomocysteinemia. J Clin Neurosci. 2005;12(6):669-72. PubMed PMID: 16040247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endothelial function markers in parkinsonian patients with hyperhomocysteinemia. AU - Bostantjopoulou,Sevasti, AU - Katsarou,Zoe, AU - Frangia,Theodora, AU - Hatzizisi,Olga, AU - Papazisis,Kostas, AU - Kyriazis,George, AU - Kiosseoglou,Gregory, AU - Kazis,Aristidis, PY - 2004/08/11/received PY - 2004/09/01/accepted PY - 2005/7/26/pubmed PY - 2006/5/26/medline PY - 2005/7/26/entrez SP - 669 EP - 72 JF - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JO - J Clin Neurosci VL - 12 IS - 6 N2 - Hyperhomocysteinemia is considered a risk factor for vascular disease causing endothelial damage and consequently atherogenesis. The purpose of this study was to investigate the effect of elevated homocysteine on certain biochemical markers of endothelial function in patients with idiopathic Parkinson's disease (PD). Blood homocysteine levels were assessed in 57 PD patients and 40 matched normal controls. Investigation of the C677T 5,10 methylenetetrahydrofolate reductase (MTHFR) genotype was also performed in 43 PD patients. The following markers of endothelial function were assessed: superoxide dismutase (SOD), nitric oxide (NO), sICAM-1 and sE-selectin. Homocysteine levels were found mildly elevated in PD patients particularly in those treated with L-Dopa. MTHFR genotype did not influence significantly this finding. SOD activity was found reduced but it was not correlated to homocysteine levels. All other parameters measured were normal and were not related to hyperhomocysteinemia. Our findings indicate that mild hyperhomocysteinemia in PD patients was not associated with endothelial dysfunction. SN - 0967-5868 UR - https://www.unboundmedicine.com/medline/citation/16040247/Endothelial_function_markers_in_parkinsonian_patients_with_hyperhomocysteinemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(05)00149-9 DB - PRIME DP - Unbound Medicine ER -