Tags

Type your tag names separated by a space and hit enter

Association of a CTLA-4 3' untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population.
Autoimmunity 2005; 38(2):151-3A

Abstract

The etiology of the autoimmune thyroid diseases (AITDs), Graves' disease (GD) and Hashimoto's thyroiditis is largely unknown. However, genetic susceptibility is believed to play a major role. The cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene, encoding a negative regulator of the T-lymphocyte immune response, had been reported to be associated and/or linked to AITD. Recently, AITD susceptibility in the Caucasians was mapped to the 6.1-kb 3'UTR of the CTLA-4 gene, in which the single-nucleotide polymorphism (SNP), CT60, was most strongly associated with AITD. In order to determine the association of the CTLA-4 gene with AITD in the Japanese, case-control association analysis for the CT60 of the CTLA-4 gene using 264 AITD patients and 179 healthy controls was done. The frequency of the disease-susceptible G allele of the CT60 of the Japanese control was higher than that of the Caucasians (72.6 vs. 52.3%). However, the G allele of the CT60 was associated with GD (84.0 vs. 72.6%, P=0.0008) and AITD (80.1 vs. 72.6%, P=0.009) in the Japanese. Furthermore, the G allele of the CT60 was associated with the increased risk for GD [P=0.004, odds ratio (OR)=2.0] and AITD (P=0.03,OR=1.6) in a recessive model. These results suggested that the CTLA-4 gene is involved in the susceptibility for GD and AITD in the Japanese.

Authors+Show Affiliations

Third Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan. yshyban@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16040335

Citation

Ban, Yoshiyuki, et al. "Association of a CTLA-4 3' Untranslated Region (CT60) Single Nucleotide Polymorphism With Autoimmune Thyroid Disease in the Japanese Population." Autoimmunity, vol. 38, no. 2, 2005, pp. 151-3.
Ban Y, Tozaki T, Taniyama M, et al. Association of a CTLA-4 3' untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population. Autoimmunity. 2005;38(2):151-3.
Ban, Y., Tozaki, T., Taniyama, M., Tomita, M., & Ban, Y. (2005). Association of a CTLA-4 3' untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population. Autoimmunity, 38(2), pp. 151-3.
Ban Y, et al. Association of a CTLA-4 3' Untranslated Region (CT60) Single Nucleotide Polymorphism With Autoimmune Thyroid Disease in the Japanese Population. Autoimmunity. 2005;38(2):151-3. PubMed PMID: 16040335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of a CTLA-4 3' untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population. AU - Ban,Yoshiyuki, AU - Tozaki,Teruaki, AU - Taniyama,Matsuo, AU - Tomita,Motowo, AU - Ban,Yoshio, PY - 2005/7/26/pubmed PY - 2005/8/27/medline PY - 2005/7/26/entrez SP - 151 EP - 3 JF - Autoimmunity JO - Autoimmunity VL - 38 IS - 2 N2 - The etiology of the autoimmune thyroid diseases (AITDs), Graves' disease (GD) and Hashimoto's thyroiditis is largely unknown. However, genetic susceptibility is believed to play a major role. The cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene, encoding a negative regulator of the T-lymphocyte immune response, had been reported to be associated and/or linked to AITD. Recently, AITD susceptibility in the Caucasians was mapped to the 6.1-kb 3'UTR of the CTLA-4 gene, in which the single-nucleotide polymorphism (SNP), CT60, was most strongly associated with AITD. In order to determine the association of the CTLA-4 gene with AITD in the Japanese, case-control association analysis for the CT60 of the CTLA-4 gene using 264 AITD patients and 179 healthy controls was done. The frequency of the disease-susceptible G allele of the CT60 of the Japanese control was higher than that of the Caucasians (72.6 vs. 52.3%). However, the G allele of the CT60 was associated with GD (84.0 vs. 72.6%, P=0.0008) and AITD (80.1 vs. 72.6%, P=0.009) in the Japanese. Furthermore, the G allele of the CT60 was associated with the increased risk for GD [P=0.004, odds ratio (OR)=2.0] and AITD (P=0.03,OR=1.6) in a recessive model. These results suggested that the CTLA-4 gene is involved in the susceptibility for GD and AITD in the Japanese. SN - 0891-6934 UR - https://www.unboundmedicine.com/medline/citation/16040335/Association_of_a_CTLA_4_3'_untranslated_region__CT60__single_nucleotide_polymorphism_with_autoimmune_thyroid_disease_in_the_Japanese_population_ L2 - http://www.tandfonline.com/doi/full/10.1080/08916930500050319 DB - PRIME DP - Unbound Medicine ER -