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Comparison of tazarotene 0.1% gel plus petrolatum once daily versus calcipotriol 0.005% ointment twice daily in the treatment of plaque psoriasis.
Acta Derm Venereol. 2005; 85(3):236-9.AD

Abstract

Tazarotene and calcipotriol are both effective in the treatment of psoriasis. An investigator-blind, bilateral comparison of 44 lesion pairs in 19 patients was conducted to evaluate the efficacy, side effects and duration of therapeutic effects of once-daily tazarotene 0.1% gel plus petrolatum with twice-daily calcipotriol 0.005% ointment in plaque psoriasis. It consisted of a 12-week treatment phase, followed by a 4-week post-treatment observation phase. At the end of the treatment phase, tazarotene-petrolatum was as effective as calcipotriol in both objective and subjective overall efficacy assessment. Calcipotriol had a significantly greater effect in reducing erythema than tazarotene-petrolatum at weeks 2-8. At week 16, tazarotene-petrolatum demonstrated a significantly better maintenance effect in all parameters. Local irritation was noted only in tazarotene-petrolatum-treated lesions. Once-daily tazarotene 0.1% gel plus petrolatum was as effective as twice-daily calcipotriol 0.005% ointment in the treatment of plaque psoriasis, but had a better maintenance effect after the cessation of therapy.

Authors+Show Affiliations

Department of Dermatology, Veterans General Hospital-Kaohsiung, 386 Ta-Chung 1st Road, Kaohsiung 813, Taiwan. tytzung@isca.vghks.gov.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16040409

Citation

Tzung, Tien-Yi, et al. "Comparison of Tazarotene 0.1% Gel Plus Petrolatum once Daily Versus Calcipotriol 0.005% Ointment Twice Daily in the Treatment of Plaque Psoriasis." Acta Dermato-venereologica, vol. 85, no. 3, 2005, pp. 236-9.
Tzung TY, Wu JC, Hsu NJ, et al. Comparison of tazarotene 0.1% gel plus petrolatum once daily versus calcipotriol 0.005% ointment twice daily in the treatment of plaque psoriasis. Acta Derm Venereol. 2005;85(3):236-9.
Tzung, T. Y., Wu, J. C., Hsu, N. J., Chen, Y. H., & Ger, L. P. (2005). Comparison of tazarotene 0.1% gel plus petrolatum once daily versus calcipotriol 0.005% ointment twice daily in the treatment of plaque psoriasis. Acta Dermato-venereologica, 85(3), 236-9.
Tzung TY, et al. Comparison of Tazarotene 0.1% Gel Plus Petrolatum once Daily Versus Calcipotriol 0.005% Ointment Twice Daily in the Treatment of Plaque Psoriasis. Acta Derm Venereol. 2005;85(3):236-9. PubMed PMID: 16040409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of tazarotene 0.1% gel plus petrolatum once daily versus calcipotriol 0.005% ointment twice daily in the treatment of plaque psoriasis. AU - Tzung,Tien-Yi, AU - Wu,Jen-Chin, AU - Hsu,Nei-Jen, AU - Chen,Ya-Hui, AU - Ger,Luo-Ping, PY - 2005/7/26/pubmed PY - 2005/9/15/medline PY - 2005/7/26/entrez SP - 236 EP - 9 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 85 IS - 3 N2 - Tazarotene and calcipotriol are both effective in the treatment of psoriasis. An investigator-blind, bilateral comparison of 44 lesion pairs in 19 patients was conducted to evaluate the efficacy, side effects and duration of therapeutic effects of once-daily tazarotene 0.1% gel plus petrolatum with twice-daily calcipotriol 0.005% ointment in plaque psoriasis. It consisted of a 12-week treatment phase, followed by a 4-week post-treatment observation phase. At the end of the treatment phase, tazarotene-petrolatum was as effective as calcipotriol in both objective and subjective overall efficacy assessment. Calcipotriol had a significantly greater effect in reducing erythema than tazarotene-petrolatum at weeks 2-8. At week 16, tazarotene-petrolatum demonstrated a significantly better maintenance effect in all parameters. Local irritation was noted only in tazarotene-petrolatum-treated lesions. Once-daily tazarotene 0.1% gel plus petrolatum was as effective as twice-daily calcipotriol 0.005% ointment in the treatment of plaque psoriasis, but had a better maintenance effect after the cessation of therapy. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/16040409/Comparison_of_tazarotene_0_1_gel_plus_petrolatum_once_daily_versus_calcipotriol_0_005_ointment_twice_daily_in_the_treatment_of_plaque_psoriasis_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.1080/00015550510027405 DB - PRIME DP - Unbound Medicine ER -