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Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep--wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats.
J Neurosci Res. 2005 Sep 15; 81(6):891-9.JN

Abstract

We used intracerebral microdialysis coupled with electrophysiologic recordings to determine relative changes in the concentrations of several neurotransmitters in the medial prefrontal cortex and nucleus accumbens of freely moving rats during waking, slow-wave sleep, and rapid eye movement (REM) sleep. The concentrations of noradrenaline, dopamine, glutamate, and aspartate in 2-min dialysate samples were analyzed by capillary electrophoresis combined with laser-induced fluorescence detection. Changes in glutamate and aspartate concentrations were found only in the nucleus accumbens, in which a decrease was obtained during both slow-wave sleep and REM sleep compared to waking. A progressive reduction in the release of noradrenaline was observed from waking to REM sleep in both structures. In contrast, dopamine concentrations were higher during waking and REM sleep compared to that during slow-wave sleep. The latter results demonstrate that contrary to the findings of earlier electrophysiologic studies carried out on ventral tegmental area dopaminergic neurons, changes in the release of dopamine in projection areas occur across the sleep-wake cycle. The elevated levels of dopamine during waking and REM sleep in the medial prefrontal cortex and the nucleus accumbens could result from changes during these two states in afferent modulation at the level of cell bodies or at the level of dopaminergic terminals.

Authors+Show Affiliations

Laboratoire de Neurobiologie Comportementale, JE 2441, Université de Nice-Sophia Antipolis, Nice, France. lena@unice.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16041801

Citation

Léna, I, et al. "Variations in Extracellular Levels of Dopamine, Noradrenaline, Glutamate, and Aspartate Across the Sleep--wake Cycle in the Medial Prefrontal Cortex and Nucleus Accumbens of Freely Moving Rats." Journal of Neuroscience Research, vol. 81, no. 6, 2005, pp. 891-9.
Léna I, Parrot S, Deschaux O, et al. Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep--wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats. J Neurosci Res. 2005;81(6):891-9.
Léna, I., Parrot, S., Deschaux, O., Muffat-Joly, S., Sauvinet, V., Renaud, B., Suaud-Chagny, M. F., & Gottesmann, C. (2005). Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep--wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats. Journal of Neuroscience Research, 81(6), 891-9.
Léna I, et al. Variations in Extracellular Levels of Dopamine, Noradrenaline, Glutamate, and Aspartate Across the Sleep--wake Cycle in the Medial Prefrontal Cortex and Nucleus Accumbens of Freely Moving Rats. J Neurosci Res. 2005 Sep 15;81(6):891-9. PubMed PMID: 16041801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep--wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats. AU - Léna,I, AU - Parrot,S, AU - Deschaux,O, AU - Muffat-Joly,S, AU - Sauvinet,V, AU - Renaud,B, AU - Suaud-Chagny,M-F, AU - Gottesmann,C, PY - 2005/7/26/pubmed PY - 2005/12/13/medline PY - 2005/7/26/entrez SP - 891 EP - 9 JF - Journal of neuroscience research JO - J Neurosci Res VL - 81 IS - 6 N2 - We used intracerebral microdialysis coupled with electrophysiologic recordings to determine relative changes in the concentrations of several neurotransmitters in the medial prefrontal cortex and nucleus accumbens of freely moving rats during waking, slow-wave sleep, and rapid eye movement (REM) sleep. The concentrations of noradrenaline, dopamine, glutamate, and aspartate in 2-min dialysate samples were analyzed by capillary electrophoresis combined with laser-induced fluorescence detection. Changes in glutamate and aspartate concentrations were found only in the nucleus accumbens, in which a decrease was obtained during both slow-wave sleep and REM sleep compared to waking. A progressive reduction in the release of noradrenaline was observed from waking to REM sleep in both structures. In contrast, dopamine concentrations were higher during waking and REM sleep compared to that during slow-wave sleep. The latter results demonstrate that contrary to the findings of earlier electrophysiologic studies carried out on ventral tegmental area dopaminergic neurons, changes in the release of dopamine in projection areas occur across the sleep-wake cycle. The elevated levels of dopamine during waking and REM sleep in the medial prefrontal cortex and the nucleus accumbens could result from changes during these two states in afferent modulation at the level of cell bodies or at the level of dopaminergic terminals. SN - 0360-4012 UR - https://www.unboundmedicine.com/medline/citation/16041801/Variations_in_extracellular_levels_of_dopamine_noradrenaline_glutamate_and_aspartate_across_the_sleep__wake_cycle_in_the_medial_prefrontal_cortex_and_nucleus_accumbens_of_freely_moving_rats_ L2 - https://doi.org/10.1002/jnr.20602 DB - PRIME DP - Unbound Medicine ER -