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Immunochemical and morphometric features of astrocyte reactivity vs. plaque location in Alzheimer's disease.
Medicina (B Aires). 2005; 65(3):213-8.M

Abstract

The quantitative relationship between glial fibrillary acidic protein (GFAP) hyper-reactivity and beta-amyloid protein (betaAP) deposition was investigated by double immunoperoxidase labeling of hippocampal and entorhinal cortex sections from five Alzheimer's disease (AD) cases and five age-matched controls. betaAP plaques, which were absent in controls, were found in all AD samples, without significant differences in number or perimeter according to their location among the regions studied. In contrast, the mean number of GFAP (+) cells was significantly greater in the hippocampus than in the entorhinal cortex from AD cases (49 vs.39). Although at lower values (30 vs. 20), predominance of astrocyte hyperplasia in hippocampus as compared with entorhinal cortex was also found in control samples. Concomitant astrocyte hypertrophy, as defined by surface density (Sv) values of GFAP-immunoreactive material exceeding those of control means, affected a similar proportion of cells in the hippocampus (73%) and the entorhinal cortex (74%) from AD cases. Since an increased number of GFAP (+) cells in the hippocampus was not accompanied by an increased number and/or perimeter of neighbouring plaques, such differential hyper-reactivity in samples from AD patients, as well as in those with normal aging, seems to depend partially on the regional location of the involved astrocyte.

Authors+Show Affiliations

Departamento de Microbiología, Facultad de Medicina, Universidad de Buenos Aires.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16042131

Citation

Vanzani, Maria C., et al. "Immunochemical and Morphometric Features of Astrocyte Reactivity Vs. Plaque Location in Alzheimer's Disease." Medicina, vol. 65, no. 3, 2005, pp. 213-8.
Vanzani MC, Iacono RF, Caccuri RL, et al. Immunochemical and morphometric features of astrocyte reactivity vs. plaque location in Alzheimer's disease. Medicina (B Aires). 2005;65(3):213-8.
Vanzani, M. C., Iacono, R. F., Caccuri, R. L., & Berria, M. I. (2005). Immunochemical and morphometric features of astrocyte reactivity vs. plaque location in Alzheimer's disease. Medicina, 65(3), 213-8.
Vanzani MC, et al. Immunochemical and Morphometric Features of Astrocyte Reactivity Vs. Plaque Location in Alzheimer's Disease. Medicina (B Aires). 2005;65(3):213-8. PubMed PMID: 16042131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunochemical and morphometric features of astrocyte reactivity vs. plaque location in Alzheimer's disease. AU - Vanzani,Maria C, AU - Iacono,Ruben F, AU - Caccuri,Roberto L, AU - Berria,Maria I, PY - 2005/7/27/pubmed PY - 2006/2/24/medline PY - 2005/7/27/entrez SP - 213 EP - 8 JF - Medicina JO - Medicina (B Aires) VL - 65 IS - 3 N2 - The quantitative relationship between glial fibrillary acidic protein (GFAP) hyper-reactivity and beta-amyloid protein (betaAP) deposition was investigated by double immunoperoxidase labeling of hippocampal and entorhinal cortex sections from five Alzheimer's disease (AD) cases and five age-matched controls. betaAP plaques, which were absent in controls, were found in all AD samples, without significant differences in number or perimeter according to their location among the regions studied. In contrast, the mean number of GFAP (+) cells was significantly greater in the hippocampus than in the entorhinal cortex from AD cases (49 vs.39). Although at lower values (30 vs. 20), predominance of astrocyte hyperplasia in hippocampus as compared with entorhinal cortex was also found in control samples. Concomitant astrocyte hypertrophy, as defined by surface density (Sv) values of GFAP-immunoreactive material exceeding those of control means, affected a similar proportion of cells in the hippocampus (73%) and the entorhinal cortex (74%) from AD cases. Since an increased number of GFAP (+) cells in the hippocampus was not accompanied by an increased number and/or perimeter of neighbouring plaques, such differential hyper-reactivity in samples from AD patients, as well as in those with normal aging, seems to depend partially on the regional location of the involved astrocyte. SN - 0025-7680 UR - https://www.unboundmedicine.com/medline/citation/16042131/Immunochemical_and_morphometric_features_of_astrocyte_reactivity_vs__plaque_location_in_Alzheimer's_disease_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -