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Electrochemistry and voltammetry of procaine using a carbon nanotube film coated electrode.
Bioelectrochemistry. 2006 May; 68(2):144-9.B

Abstract

A new rapid, convenient and sensitive electrochemical method is described for the determination of procaine in pharmaceutical preparations, based on the unique properties of a multi-wall carbon nanotube (MWNT) thin film. The electrochemical behavior of procaine at the MWNT film-coated glassy carbon electrode (GCE) was investigated in detail, showing that the MWNT-coated GCE exhibits electrocatalytic activity to the oxidation of procaine because of the significant peak current enhancement and the lowering of oxidation overpotential. Furthermore, the mechanism for the oxidation of procaine at the MWNT-coated GCE was also studied. Finally, various experimental parameters such as solution pH value, the amount of MWNT, accumulation conditions and scan rate were optimized for the determination of procaine, and a new method with detection limit of 2 x 10(-7) mol/L was developed for procaine determination. This newly proposed method was successfully demonstrated with procaine hydrochloride injection.

Authors+Show Affiliations

Wu K
Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, P.R. China. kbwu@mail.hust.edu.cn
Wang H
No affiliation info available
Chen F
No affiliation info available
Hu S
No affiliation info available

MeSH

Biosensing TechniquesElectric ConductivityElectrochemistryEquipment DesignEquipment Failure AnalysisMicroelectrodesNanotubes, CarbonProcaineReproducibility of ResultsSensitivity and Specificity

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16043422

Citation

Wu, Kangbing, et al. "Electrochemistry and Voltammetry of Procaine Using a Carbon Nanotube Film Coated Electrode." Bioelectrochemistry (Amsterdam, Netherlands), vol. 68, no. 2, 2006, pp. 144-9.
Wu K, Wang H, Chen F, et al. Electrochemistry and voltammetry of procaine using a carbon nanotube film coated electrode. Bioelectrochemistry. 2006;68(2):144-9.
Wu, K., Wang, H., Chen, F., & Hu, S. (2006). Electrochemistry and voltammetry of procaine using a carbon nanotube film coated electrode. Bioelectrochemistry (Amsterdam, Netherlands), 68(2), 144-9.
Wu K, et al. Electrochemistry and Voltammetry of Procaine Using a Carbon Nanotube Film Coated Electrode. Bioelectrochemistry. 2006;68(2):144-9. PubMed PMID: 16043422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrochemistry and voltammetry of procaine using a carbon nanotube film coated electrode. AU - Wu,Kangbing, AU - Wang,Hong, AU - Chen,Fang, AU - Hu,Shengshui, Y1 - 2005/07/25/ PY - 2005/03/24/received PY - 2005/05/06/revised PY - 2005/05/09/accepted PY - 2005/7/27/pubmed PY - 2006/8/5/medline PY - 2005/7/27/entrez SP - 144 EP - 9 JF - Bioelectrochemistry (Amsterdam, Netherlands) JO - Bioelectrochemistry VL - 68 IS - 2 N2 - A new rapid, convenient and sensitive electrochemical method is described for the determination of procaine in pharmaceutical preparations, based on the unique properties of a multi-wall carbon nanotube (MWNT) thin film. The electrochemical behavior of procaine at the MWNT film-coated glassy carbon electrode (GCE) was investigated in detail, showing that the MWNT-coated GCE exhibits electrocatalytic activity to the oxidation of procaine because of the significant peak current enhancement and the lowering of oxidation overpotential. Furthermore, the mechanism for the oxidation of procaine at the MWNT-coated GCE was also studied. Finally, various experimental parameters such as solution pH value, the amount of MWNT, accumulation conditions and scan rate were optimized for the determination of procaine, and a new method with detection limit of 2 x 10(-7) mol/L was developed for procaine determination. This newly proposed method was successfully demonstrated with procaine hydrochloride injection. SN - 1567-5394 UR - https://www.unboundmedicine.com/medline/citation/16043422/Electrochemistry_and_voltammetry_of_procaine_using_a_carbon_nanotube_film_coated_electrode_ DB - PRIME DP - Unbound Medicine ER -