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Accelerated longitudinal decline of aerobic capacity in healthy older adults.

Abstract

BACKGROUND

The ability of older persons to function independently is dependent largely on the maintenance of sufficient aerobic capacity and strength to perform daily activities. Although peak aerobic capacity is widely recognized to decline with age, its rate of decline has been estimated primarily from cross-sectional studies that may provide misleading, overly optimistic estimates of aging changes.

METHODS AND RESULTS

To determine longitudinal rate of change in aerobic capacity and the influence of age, gender, and physical activity on these changes, we performed serial measurements of peak treadmill oxygen consumption (peak VO2) in 375 women and 435 men ages 21 to 87 years from the Baltimore Longitudinal Study of Aging, a community-dwelling cohort free of clinical heart disease, over a median follow-up period of 7.9 years. A linear mixed-effects regression model was used to calculate the predicted longitudinal 10-year rate of change in peak VO2, expressed in milliliters per minute, for each age decade from the 20s through the 70s after adjustment for self-reported leisure-time physical activity. A longitudinal decline in peak VO2 was observed in each of the 6 age decades in both sexes; however, the rate of decline accelerated from 3% to 6% per 10 years in the 20s and 30s to >20% per 10 years in the 70s and beyond. The rate of decline for each decade was larger in men than in women from the 40s onward. Similar longitudinal rates of decline prevailed when peak VO2 was indexed per kilogram of body weight or per kilogram of fat-free mass and in all quartiles of self-reported leisure-time physical activity. When the components of peak VO2 were examined, the rate of longitudinal decline of the oxygen pulse (ie, the O2 utilization per heart beat) mirrored that of peak VO2, whereas the longitudinal rate of heart rate decline averaged only 4% to 6% per 10 years, and accelerated only minimally with age.

CONCLUSIONS

The longitudinal rate of decline in peak VO2 in healthy adults is not constant across the age span in healthy persons, as assumed by cross-sectional studies, but accelerates markedly with each successive age decade, especially in men, regardless of physical activity habits. The accelerated rate of decline of peak aerobic capacity has substantial implications with regard to functional independence and quality of life, not only in healthy older persons, but particularly when disease-related deficits are superimposed.

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  • Authors+Show Affiliations

    ,

    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. flegj@nhlbi.nih.gov

    , , , , ,

    Source

    Circulation 112:5 2005 Aug 02 pg 674-82

    MeSH

    Adult
    Aerobiosis
    Aged
    Aged, 80 and over
    Aging
    Exercise
    Female
    Humans
    Leisure Activities
    Longitudinal Studies
    Male
    Middle Aged
    Oxygen Consumption
    Physical Fitness
    Reference Values

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16043637

    Citation

    Fleg, Jerome L., et al. "Accelerated Longitudinal Decline of Aerobic Capacity in Healthy Older Adults." Circulation, vol. 112, no. 5, 2005, pp. 674-82.
    Fleg JL, Morrell CH, Bos AG, et al. Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation. 2005;112(5):674-82.
    Fleg, J. L., Morrell, C. H., Bos, A. G., Brant, L. J., Talbot, L. A., Wright, J. G., & Lakatta, E. G. (2005). Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation, 112(5), pp. 674-82.
    Fleg JL, et al. Accelerated Longitudinal Decline of Aerobic Capacity in Healthy Older Adults. Circulation. 2005 Aug 2;112(5):674-82. PubMed PMID: 16043637.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Accelerated longitudinal decline of aerobic capacity in healthy older adults. AU - Fleg,Jerome L, AU - Morrell,Christopher H, AU - Bos,Angelo G, AU - Brant,Larry J, AU - Talbot,Laura A, AU - Wright,Jeanette G, AU - Lakatta,Edward G, Y1 - 2005/07/25/ PY - 2005/7/27/pubmed PY - 2006/2/16/medline PY - 2005/7/27/entrez SP - 674 EP - 82 JF - Circulation JO - Circulation VL - 112 IS - 5 N2 - BACKGROUND: The ability of older persons to function independently is dependent largely on the maintenance of sufficient aerobic capacity and strength to perform daily activities. Although peak aerobic capacity is widely recognized to decline with age, its rate of decline has been estimated primarily from cross-sectional studies that may provide misleading, overly optimistic estimates of aging changes. METHODS AND RESULTS: To determine longitudinal rate of change in aerobic capacity and the influence of age, gender, and physical activity on these changes, we performed serial measurements of peak treadmill oxygen consumption (peak VO2) in 375 women and 435 men ages 21 to 87 years from the Baltimore Longitudinal Study of Aging, a community-dwelling cohort free of clinical heart disease, over a median follow-up period of 7.9 years. A linear mixed-effects regression model was used to calculate the predicted longitudinal 10-year rate of change in peak VO2, expressed in milliliters per minute, for each age decade from the 20s through the 70s after adjustment for self-reported leisure-time physical activity. A longitudinal decline in peak VO2 was observed in each of the 6 age decades in both sexes; however, the rate of decline accelerated from 3% to 6% per 10 years in the 20s and 30s to >20% per 10 years in the 70s and beyond. The rate of decline for each decade was larger in men than in women from the 40s onward. Similar longitudinal rates of decline prevailed when peak VO2 was indexed per kilogram of body weight or per kilogram of fat-free mass and in all quartiles of self-reported leisure-time physical activity. When the components of peak VO2 were examined, the rate of longitudinal decline of the oxygen pulse (ie, the O2 utilization per heart beat) mirrored that of peak VO2, whereas the longitudinal rate of heart rate decline averaged only 4% to 6% per 10 years, and accelerated only minimally with age. CONCLUSIONS: The longitudinal rate of decline in peak VO2 in healthy adults is not constant across the age span in healthy persons, as assumed by cross-sectional studies, but accelerates markedly with each successive age decade, especially in men, regardless of physical activity habits. The accelerated rate of decline of peak aerobic capacity has substantial implications with regard to functional independence and quality of life, not only in healthy older persons, but particularly when disease-related deficits are superimposed. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/16043637/Accelerated_longitudinal_decline_of_aerobic_capacity_in_healthy_older_adults_ L2 - http://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.105.545459?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -