Tags

Type your tag names separated by a space and hit enter

Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD.
Neurology. 2005 Jul 26; 65(2):247-52.Neur

Abstract

OBJECTIVE

To compare the clinical and video-polysomnographic (VPSG) characteristics of idiopathic REM sleep behavior disorder (RBD) vs the RBD seen in multiple system atrophy (MSA) and Parkinson disease (PD).

METHODS

Clinical features and VPSG measures were evaluated in 110 consecutive nondemented subjects (26 MSA, 45 PD, and 39 idiopathic RBD) free of psychoactive medications referred for suspected RBD to our sleep unit over a 5-year period, with extended follow-up (mean 26.9 +/- 21.3 months).

RESULTS

Across the three groups studied, logistic regression analysis demonstrated that there were no differences in the quality of RBD symptoms (e.g., nature of unpleasant dream recall or behaviors witnessed by bed partners), most PSG variables, abnormal behaviors captured by VPSG, and clinical response to clonazepam. When compared to subjects with PD, however, patients with MSA had a significantly shorter duration of disease, a higher REM sleep without atonia percentage, a greater periodic leg movement index, and less total sleep time. Subjects with idiopathic RBD, as compared to those with either MSA or PD, were more often male, had greater self-reported clinical RBD severity, and were more often aware of their abnormal sleep behaviors.

CONCLUSIONS

REM sleep behavior disorder (RBD)-related symptoms and neurophysiologic features are qualitatively similar in RBD subjects with the idiopathic form, multiple system atrophy (MSA), and Parkinson disease (PD). Polysomnographic abnormalities associated with RBD in the setting of MSA are greater than in PD, suggesting a more severe dysfunction in the structures that modulate REM sleep.

Authors+Show Affiliations

Neurology Service, ospital Clínic and Institut d'Investigació Biomèdiques August Pi i Sunyer, Barcelona, Spain. airanzo@clinic.ub.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16043794

Citation

Iranzo, A, et al. "Characteristics of Idiopathic REM Sleep Behavior Disorder and That Associated With MSA and PD." Neurology, vol. 65, no. 2, 2005, pp. 247-52.
Iranzo A, Santamaría J, Rye DB, et al. Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD. Neurology. 2005;65(2):247-52.
Iranzo, A., Santamaría, J., Rye, D. B., Valldeoriola, F., Martí, M. J., Muñoz, E., Vilaseca, I., & Tolosa, E. (2005). Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD. Neurology, 65(2), 247-52.
Iranzo A, et al. Characteristics of Idiopathic REM Sleep Behavior Disorder and That Associated With MSA and PD. Neurology. 2005 Jul 26;65(2):247-52. PubMed PMID: 16043794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD. AU - Iranzo,A, AU - Santamaría,J, AU - Rye,D B, AU - Valldeoriola,F, AU - Martí,M J, AU - Muñoz,E, AU - Vilaseca,I, AU - Tolosa,E, PY - 2005/7/27/pubmed PY - 2006/1/5/medline PY - 2005/7/27/entrez SP - 247 EP - 52 JF - Neurology JO - Neurology VL - 65 IS - 2 N2 - OBJECTIVE: To compare the clinical and video-polysomnographic (VPSG) characteristics of idiopathic REM sleep behavior disorder (RBD) vs the RBD seen in multiple system atrophy (MSA) and Parkinson disease (PD). METHODS: Clinical features and VPSG measures were evaluated in 110 consecutive nondemented subjects (26 MSA, 45 PD, and 39 idiopathic RBD) free of psychoactive medications referred for suspected RBD to our sleep unit over a 5-year period, with extended follow-up (mean 26.9 +/- 21.3 months). RESULTS: Across the three groups studied, logistic regression analysis demonstrated that there were no differences in the quality of RBD symptoms (e.g., nature of unpleasant dream recall or behaviors witnessed by bed partners), most PSG variables, abnormal behaviors captured by VPSG, and clinical response to clonazepam. When compared to subjects with PD, however, patients with MSA had a significantly shorter duration of disease, a higher REM sleep without atonia percentage, a greater periodic leg movement index, and less total sleep time. Subjects with idiopathic RBD, as compared to those with either MSA or PD, were more often male, had greater self-reported clinical RBD severity, and were more often aware of their abnormal sleep behaviors. CONCLUSIONS: REM sleep behavior disorder (RBD)-related symptoms and neurophysiologic features are qualitatively similar in RBD subjects with the idiopathic form, multiple system atrophy (MSA), and Parkinson disease (PD). Polysomnographic abnormalities associated with RBD in the setting of MSA are greater than in PD, suggesting a more severe dysfunction in the structures that modulate REM sleep. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16043794/Characteristics_of_idiopathic_REM_sleep_behavior_disorder_and_that_associated_with_MSA_and_PD_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16043794 DB - PRIME DP - Unbound Medicine ER -