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The effectiveness of montelukast for the treatment of anti-histamine-resistant chronic urticaria.
Arch Dermatol Res. 2005 Sep; 297(3):134-8.AD

Abstract

Many patients with chronic idiopathic urticaria are not sufficiently controlled with histamine H(1)-receptor antagonists. Leukotriene receptor antagonists have been reported to be effective for certain cases of urticaria, although their proper application remains to be established. To study the effectiveness of montelukast, a leukotriene receptor antagonist, for the treatment of chronic urticaria that was not controlled by histamine H(1)-receptor antagonists. Twenty-five patients with chronic idiopathic urticaria were treated with 10 mg of montelukast for one week or more, without changing any precedent treatment that they were using before the study including histamine H(1)-receptor antagonists. The effectiveness of montelukast for each patient was evaluated and compared with clinical features and/or backgrounds of the patients. Twelve patients, including six who had been treated with corticosteroids, were evaluated as "markedly improved" or "improved" following treatment with montelukast. There was no statistically significant relation of the effectiveness to the complications with non-steroidal anti-inflammatory drugs (NSAIDs) intolerance, mechanical urticaria, or reactions to autologous serum skin test. However, the patients for whom montelukast was effective were younger (33.2+/-16.3 years, mean +/- SD)(P<0.05, Mann-Whitney test) and their duration of illness shorter (15.9+/-18.3 months) (P<0.005, Mann-Whitney test) than those of patients for whom montelukast was ineffective (45.9+/-15.0 years, 89.6+/-71.7 months). Montelukast may be worth trying for patients with chronic idiopathic urticaria, when the condition is not sufficiently controlled with histamine H(1)-receptor antagonists.

Authors+Show Affiliations

Department of Dermatology, Programs for Biomedical Research, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16044256

Citation

Sanada, Seiko, et al. "The Effectiveness of Montelukast for the Treatment of Anti-histamine-resistant Chronic Urticaria." Archives of Dermatological Research, vol. 297, no. 3, 2005, pp. 134-8.
Sanada S, Tanaka T, Kameyoshi Y, et al. The effectiveness of montelukast for the treatment of anti-histamine-resistant chronic urticaria. Arch Dermatol Res. 2005;297(3):134-8.
Sanada, S., Tanaka, T., Kameyoshi, Y., & Hide, M. (2005). The effectiveness of montelukast for the treatment of anti-histamine-resistant chronic urticaria. Archives of Dermatological Research, 297(3), 134-8.
Sanada S, et al. The Effectiveness of Montelukast for the Treatment of Anti-histamine-resistant Chronic Urticaria. Arch Dermatol Res. 2005;297(3):134-8. PubMed PMID: 16044256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effectiveness of montelukast for the treatment of anti-histamine-resistant chronic urticaria. AU - Sanada,Seiko, AU - Tanaka,Toshihiko, AU - Kameyoshi,Yoshikazu, AU - Hide,Michihiro, Y1 - 2005/09/29/ PY - 2005/03/16/received PY - 2005/07/01/accepted PY - 2005/06/28/revised PY - 2005/7/27/pubmed PY - 2006/7/1/medline PY - 2005/7/27/entrez SP - 134 EP - 8 JF - Archives of dermatological research JO - Arch Dermatol Res VL - 297 IS - 3 N2 - Many patients with chronic idiopathic urticaria are not sufficiently controlled with histamine H(1)-receptor antagonists. Leukotriene receptor antagonists have been reported to be effective for certain cases of urticaria, although their proper application remains to be established. To study the effectiveness of montelukast, a leukotriene receptor antagonist, for the treatment of chronic urticaria that was not controlled by histamine H(1)-receptor antagonists. Twenty-five patients with chronic idiopathic urticaria were treated with 10 mg of montelukast for one week or more, without changing any precedent treatment that they were using before the study including histamine H(1)-receptor antagonists. The effectiveness of montelukast for each patient was evaluated and compared with clinical features and/or backgrounds of the patients. Twelve patients, including six who had been treated with corticosteroids, were evaluated as "markedly improved" or "improved" following treatment with montelukast. There was no statistically significant relation of the effectiveness to the complications with non-steroidal anti-inflammatory drugs (NSAIDs) intolerance, mechanical urticaria, or reactions to autologous serum skin test. However, the patients for whom montelukast was effective were younger (33.2+/-16.3 years, mean +/- SD)(P<0.05, Mann-Whitney test) and their duration of illness shorter (15.9+/-18.3 months) (P<0.005, Mann-Whitney test) than those of patients for whom montelukast was ineffective (45.9+/-15.0 years, 89.6+/-71.7 months). Montelukast may be worth trying for patients with chronic idiopathic urticaria, when the condition is not sufficiently controlled with histamine H(1)-receptor antagonists. SN - 0340-3696 UR - https://www.unboundmedicine.com/medline/citation/16044256/The_effectiveness_of_montelukast_for_the_treatment_of_anti_histamine_resistant_chronic_urticaria_ L2 - https://link.springer.com/article/10.1007/s00403-005-0586-4 DB - PRIME DP - Unbound Medicine ER -