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[Cardiac amyloidosis revealing multiple myeloma].
Tunis Med. 2005 May; 83(5):300-4.TM

Abstract

INTRODUCTION

Amyloidosis is a rare disease characterized by an extracellular accumulation of a protein polysaccharid complex (Amyloid). Cardiac involvement is considered as a major prognostic factor.

OBSERVATIONS

We report the case of two women, hospitalized for heart failure. The diagnosis of cardiac amyloidosis was suggested by echocardiography: Left ventricular concentric hypertrophy and typical amyeloid infiltration with hyperechoic, shiny and granite-like aspect of the interventricular septum. The histological confirmation was obtained by gastric biopsy in the first case and biopsy of the salivary glands in the second revealing an amyloidosis AL. This cardiac amyloidosis was secondary to multiple myeloma: monoclonal Gammopathy with immunoglobulin Lambda in the first and Kappa in the second, and the presence of a plasmocyte infiltration in the sternal puncture.

CONCLUSION

Amyloidosis is a rare pathology, the cardiac involvement is frequent in the type AL and can occur with or without clinical manifestations. Echocardiography should be systematic in patients with confirmed amyloidosis.

Authors+Show Affiliations

Denguir H
Service de cardiologie du CHU de Monastir.
Ben-Hamda K
No affiliation info available
Gharbi M
No affiliation info available
Addad F
No affiliation info available
Hammami S
No affiliation info available
Mlika A
No affiliation info available
Abbes F
No affiliation info available
Moussa A
No affiliation info available
Betbout F
No affiliation info available
Gamra H
No affiliation info available
Maatouk F
No affiliation info available
Dridi Z
No affiliation info available
Zakhama A
No affiliation info available
Mahjoub S
No affiliation info available
Ben-Farhat M
No affiliation info available

MeSH

AmyloidosisBiopsyEchocardiographyFemaleHeart DiseasesHumansMiddle AgedMultiple MyelomaPrognosis

Pub Type(s)

Case Reports
Journal Article

Language

fre

PubMed ID

16044906

Citation

Denguir, Hichem, et al. "[Cardiac Amyloidosis Revealing Multiple Myeloma]." La Tunisie Medicale, vol. 83, no. 5, 2005, pp. 300-4.
Denguir H, Ben-Hamda K, Gharbi M, et al. [Cardiac amyloidosis revealing multiple myeloma]. Tunis Med. 2005;83(5):300-4.
Denguir, H., Ben-Hamda, K., Gharbi, M., Addad, F., Hammami, S., Mlika, A., Abbes, F., Moussa, A., Betbout, F., Gamra, H., Maatouk, F., Dridi, Z., Zakhama, A., Mahjoub, S., & Ben-Farhat, M. (2005). [Cardiac amyloidosis revealing multiple myeloma]. La Tunisie Medicale, 83(5), 300-4.
Denguir H, et al. [Cardiac Amyloidosis Revealing Multiple Myeloma]. Tunis Med. 2005;83(5):300-4. PubMed PMID: 16044906.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cardiac amyloidosis revealing multiple myeloma]. AU - Denguir,Hichem, AU - Ben-Hamda,Khaldoun, AU - Gharbi,Mostari, AU - Addad,Faouzi, AU - Hammami,Sonia, AU - Mlika,Azmi, AU - Abbes,Fehmi, AU - Moussa,Adnene, AU - Betbout,Fethi, AU - Gamra,Habib, AU - Maatouk,Faouzi, AU - Dridi,Zohra, AU - Zakhama,Abdelfettah, AU - Mahjoub,Sylvia, AU - Ben-Farhat,Mohamed, PY - 2005/7/28/pubmed PY - 2005/8/24/medline PY - 2005/7/28/entrez SP - 300 EP - 4 JF - La Tunisie medicale JO - Tunis Med VL - 83 IS - 5 N2 - INTRODUCTION: Amyloidosis is a rare disease characterized by an extracellular accumulation of a protein polysaccharid complex (Amyloid). Cardiac involvement is considered as a major prognostic factor. OBSERVATIONS: We report the case of two women, hospitalized for heart failure. The diagnosis of cardiac amyloidosis was suggested by echocardiography: Left ventricular concentric hypertrophy and typical amyeloid infiltration with hyperechoic, shiny and granite-like aspect of the interventricular septum. The histological confirmation was obtained by gastric biopsy in the first case and biopsy of the salivary glands in the second revealing an amyloidosis AL. This cardiac amyloidosis was secondary to multiple myeloma: monoclonal Gammopathy with immunoglobulin Lambda in the first and Kappa in the second, and the presence of a plasmocyte infiltration in the sternal puncture. CONCLUSION: Amyloidosis is a rare pathology, the cardiac involvement is frequent in the type AL and can occur with or without clinical manifestations. Echocardiography should be systematic in patients with confirmed amyloidosis. SN - 0041-4131 UR - https://www.unboundmedicine.com/medline/citation/16044906/[Cardiac_amyloidosis_revealing_multiple_myeloma]_ L2 - http://www.diseaseinfosearch.org/result/4962 DB - PRIME DP - Unbound Medicine ER -