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Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex.
Eur J Neurosci. 2005 Jul; 22(2):485-94.EJ

Abstract

The anterior cingulate cortex (ACC) is thought to be important for the establishment, consolidation and retrieval of permanent memory. In many brain regions, including the hippocampus, it is suggested that long-term potentiation (LTP) and long-term depression (LTD), the cellular mechanisms for learning and memory, require the activation of glutamate N-methyl-D-aspartate receptors (NMDARs). In the hippocampus, the NR2A subunit is believed to be involved in the induction of LTP, whereas the NR2B subunit contributes to the formation of LTD. However, LTD has been less well studied in the ACC as compared with the hippocampus and little is known about the role of NMDA subtype receptors in cingulate LTD. Here we show that LTD can be induced by the combination of presynaptic stimulation with postsynaptic depolarization ('pairing training') in adult mouse ACC neurons. This form of LTD is an NMDAR- and voltage-dependent mechanism and a postsynaptic Ca2+ increase is required for the induction of LTD. Furthermore, our studies provide direct physiological evidence that both NR2A and NR2B subunits are involved in the induction of LTD in the ACC.

Authors+Show Affiliations

Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16045501

Citation

Toyoda, Hiroki, et al. "Roles of NMDA Receptor NR2A and NR2B Subtypes for Long-term Depression in the Anterior Cingulate Cortex." The European Journal of Neuroscience, vol. 22, no. 2, 2005, pp. 485-94.
Toyoda H, Zhao MG, Zhuo M. Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex. Eur J Neurosci. 2005;22(2):485-94.
Toyoda, H., Zhao, M. G., & Zhuo, M. (2005). Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex. The European Journal of Neuroscience, 22(2), 485-94.
Toyoda H, Zhao MG, Zhuo M. Roles of NMDA Receptor NR2A and NR2B Subtypes for Long-term Depression in the Anterior Cingulate Cortex. Eur J Neurosci. 2005;22(2):485-94. PubMed PMID: 16045501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex. AU - Toyoda,Hiroki, AU - Zhao,Ming-Gao, AU - Zhuo,Min, PY - 2005/7/28/pubmed PY - 2005/9/24/medline PY - 2005/7/28/entrez SP - 485 EP - 94 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 22 IS - 2 N2 - The anterior cingulate cortex (ACC) is thought to be important for the establishment, consolidation and retrieval of permanent memory. In many brain regions, including the hippocampus, it is suggested that long-term potentiation (LTP) and long-term depression (LTD), the cellular mechanisms for learning and memory, require the activation of glutamate N-methyl-D-aspartate receptors (NMDARs). In the hippocampus, the NR2A subunit is believed to be involved in the induction of LTP, whereas the NR2B subunit contributes to the formation of LTD. However, LTD has been less well studied in the ACC as compared with the hippocampus and little is known about the role of NMDA subtype receptors in cingulate LTD. Here we show that LTD can be induced by the combination of presynaptic stimulation with postsynaptic depolarization ('pairing training') in adult mouse ACC neurons. This form of LTD is an NMDAR- and voltage-dependent mechanism and a postsynaptic Ca2+ increase is required for the induction of LTD. Furthermore, our studies provide direct physiological evidence that both NR2A and NR2B subunits are involved in the induction of LTD in the ACC. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/16045501/Roles_of_NMDA_receptor_NR2A_and_NR2B_subtypes_for_long_term_depression_in_the_anterior_cingulate_cortex_ DB - PRIME DP - Unbound Medicine ER -