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Depressive symptoms of type 2 diabetics treated with insulin compared to diabetics taking oral anti-diabetic drugs: a Korean study.

Abstract

OBJECTIVE

The purpose of this study was to examine the depressive symptoms of type 2 diabetic patients who were treated with insulin compared to those diabetics treated with oral anti-diabetic drugs in Korea.

METHODS

A total 204 outpatients with type 2 diabetes were invited to complete a questionnaire using the Beck depression inventory (BDI) to measure depressive symptoms. Age, gender, body mass index, serum lipid profile, and a social history including marital status, occupation and educational background were also assessed. The presence of diabetic complications was evaluated by examining the patients' medical records. Diabetic patients who were not treated with anti-diabetic drugs were excluded. All the study subjects were classified into two groups based on their mode of therapy: the oral drug group and insulin group. The insulin group included patients treated with insulin-oral drug combinations as well as those treated solely with insulin.

RESULTS

Overall, 32.4% of our diabetic subjects showed depressive symptoms with the criterion being a BDI score > or = 16. Compared to the oral drug group, the insulin group showed a significantly higher frequency of depressive symptoms (insulin group, 48.0%; oral drug group, 27.3%; p<0.01) and higher BDI scores (insulin group, 16.6+/-10.7; oral drug group, 12.6+/-8.7; p<0.01). Moreover, after an adjustment for social factors, the degree of hyperglycemia and the presence of diabetic complications, the insulin group showed a significantly higher frequency of depression (odds ratio 4.38, 95% CI 1.66-11.6, p=0.003), compared to the oral drug group.

CONCLUSIONS

The data showed that insulin treatment is related to the presence of depressive symptoms, and the importance of more careful psychological support of Korean insulin-treated type 2 diabetic patients is strongly suggested.

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  • Authors+Show Affiliations

    ,

    Division of Endocrinology and Metabolism, Department of Internal Medicine, Inje University College of Medicine, Republic of Korea.

    , , , , , , , ,

    Source

    MeSH

    Administration, Oral
    Depression
    Diabetes Mellitus, Type 2
    Female
    Humans
    Hypoglycemic Agents
    Insulin
    Korea
    Male
    Middle Aged
    Regression Analysis

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    16046024

    Citation

    Noh, J H., et al. "Depressive Symptoms of Type 2 Diabetics Treated With Insulin Compared to Diabetics Taking Oral Anti-diabetic Drugs: a Korean Study." Diabetes Research and Clinical Practice, vol. 69, no. 3, 2005, pp. 243-8.
    Noh JH, Park JK, Lee HJ, et al. Depressive symptoms of type 2 diabetics treated with insulin compared to diabetics taking oral anti-diabetic drugs: a Korean study. Diabetes Res Clin Pract. 2005;69(3):243-8.
    Noh, J. H., Park, J. K., Lee, H. J., Kwon, S. K., Lee, S. H., Park, J. H., ... Kim, D. J. (2005). Depressive symptoms of type 2 diabetics treated with insulin compared to diabetics taking oral anti-diabetic drugs: a Korean study. Diabetes Research and Clinical Practice, 69(3), pp. 243-8.
    Noh JH, et al. Depressive Symptoms of Type 2 Diabetics Treated With Insulin Compared to Diabetics Taking Oral Anti-diabetic Drugs: a Korean Study. Diabetes Res Clin Pract. 2005;69(3):243-8. PubMed PMID: 16046024.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Depressive symptoms of type 2 diabetics treated with insulin compared to diabetics taking oral anti-diabetic drugs: a Korean study. AU - Noh,J H, AU - Park,J K, AU - Lee,H J, AU - Kwon,S K, AU - Lee,S H, AU - Park,J H, AU - Ko,K S, AU - Rhee,B D, AU - Lim,K H, AU - Kim,D J, PY - 2004/02/06/received PY - 2004/05/24/revised PY - 2004/10/13/accepted PY - 2005/7/28/pubmed PY - 2005/10/5/medline PY - 2005/7/28/entrez SP - 243 EP - 8 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 69 IS - 3 N2 - OBJECTIVE: The purpose of this study was to examine the depressive symptoms of type 2 diabetic patients who were treated with insulin compared to those diabetics treated with oral anti-diabetic drugs in Korea. METHODS: A total 204 outpatients with type 2 diabetes were invited to complete a questionnaire using the Beck depression inventory (BDI) to measure depressive symptoms. Age, gender, body mass index, serum lipid profile, and a social history including marital status, occupation and educational background were also assessed. The presence of diabetic complications was evaluated by examining the patients' medical records. Diabetic patients who were not treated with anti-diabetic drugs were excluded. All the study subjects were classified into two groups based on their mode of therapy: the oral drug group and insulin group. The insulin group included patients treated with insulin-oral drug combinations as well as those treated solely with insulin. RESULTS: Overall, 32.4% of our diabetic subjects showed depressive symptoms with the criterion being a BDI score > or = 16. Compared to the oral drug group, the insulin group showed a significantly higher frequency of depressive symptoms (insulin group, 48.0%; oral drug group, 27.3%; p<0.01) and higher BDI scores (insulin group, 16.6+/-10.7; oral drug group, 12.6+/-8.7; p<0.01). Moreover, after an adjustment for social factors, the degree of hyperglycemia and the presence of diabetic complications, the insulin group showed a significantly higher frequency of depression (odds ratio 4.38, 95% CI 1.66-11.6, p=0.003), compared to the oral drug group. CONCLUSIONS: The data showed that insulin treatment is related to the presence of depressive symptoms, and the importance of more careful psychological support of Korean insulin-treated type 2 diabetic patients is strongly suggested. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/16046024/Depressive_symptoms_of_type_2_diabetics_treated_with_insulin_compared_to_diabetics_taking_oral_anti_diabetic_drugs:_a_Korean_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(04)00312-2 DB - PRIME DP - Unbound Medicine ER -