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Overweight women with polycystic ovary syndrome have evidence of subclinical cardiovascular disease.
J Clin Endocrinol Metab. 2005 Oct; 90(10):5711-6.JC

Abstract

CONTEXT

Polycystic ovary syndrome (PCOS) is associated with insulin resistance (IR) and the metabolic syndrome. There are no adequate data demonstrating significantly increased cardiovascular disease (CVD) mortality. In the absence of clinical outcome studies, surrogate markers of early CVD can provide insight into early CVD.

OBJECTIVE

The aim of this study was to clarify whether overweight women with PCOS have an increased prevalence of cardiovascular risk factors and early CVD, compared with age- and body mass index-matched controls, to determine the contribution of PCOS per se to CVD status.

DESIGN AND PATIENTS

This was a case control study of 100 overweight women with PCOS and 20 subjects of similar body mass index and age.

MAIN OUTCOME MEASURES

Noninvasive markers of early CVD [carotid intimal media thickness, pulse wave velocity (PWV), and brachial arterial flow-mediated vasodilation] were measured. Metabolic parameters studied included insulin, glucose, C-reactive protein, lipids, and androgens.

RESULTS

Subjects with PCOS had elevated testosterone (2.5 +/- 0.2 vs. 1.3 +/- 0.1 nmol/liter), dehydroepiandrosterone sulfate (4.9 +/- 0.3 vs. 3.6 +/- 0.4 mmol/liter), fasting insulin (19.6 +/- 1.4 vs. 6.8 +/- 0.8 microU/ml), and homeostasis model assessment of IR (4.1 +/- 0.3 vs. 1.3 +/- 0.2), compared with controls. In addition, those with PCOS had elevated cholesterol (5.1 +/- 0.1 vs. 4.6 +/- 0.2 mmol/liter) and triglycerides (1.4 +/- 0.1 vs. 0.9 +/- 0.1 mmol/liter), whereas there were no differences in either C-reactive protein or 24-h ambulatory blood pressure parameters. Subjects with PCOS also had increased arterial stiffness (PWV, 7.4 +/- 0.1 vs. 6.6 +/- 0.2 m/sec) and endothelial dysfunction (flow-mediated vasodilation, 9.8 +/- 0.4 vs. 13.3 +/- 0.9), compared with controls. There was no difference in mean intimal media thickness between the groups. Stepwise regression in PCOS subjects showed that IR and lipids were independent predictors of PWV.

CONCLUSION

Overweight women with PCOS have increased cardiovascular risk factors and evidence of early CVD, compared with weight-matched controls, potentially related to IR.

Authors+Show Affiliations

Meyer C
Monash University Department of Medicine, Dandenong Hospital, Melbourne, Victoria 3175, Australia.
McGrath BP
No affiliation info available
Teede HJ
No affiliation info available

MeSH

AdultAndrogensAustraliaBlood CirculationBlood PressureBlood Pressure Monitoring, AmbulatoryBody Mass IndexBrachial ArteryCardiovascular DiseasesCarotid ArteriesFemaleHormonesHumansLipidsMenstruationObesityPolycystic Ovary SyndromeRisk Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16046590

Citation

Meyer, C, et al. "Overweight Women With Polycystic Ovary Syndrome Have Evidence of Subclinical Cardiovascular Disease." The Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 10, 2005, pp. 5711-6.
Meyer C, McGrath BP, Teede HJ. Overweight women with polycystic ovary syndrome have evidence of subclinical cardiovascular disease. J Clin Endocrinol Metab. 2005;90(10):5711-6.
Meyer, C., McGrath, B. P., & Teede, H. J. (2005). Overweight women with polycystic ovary syndrome have evidence of subclinical cardiovascular disease. The Journal of Clinical Endocrinology and Metabolism, 90(10), 5711-6.
Meyer C, McGrath BP, Teede HJ. Overweight Women With Polycystic Ovary Syndrome Have Evidence of Subclinical Cardiovascular Disease. J Clin Endocrinol Metab. 2005;90(10):5711-6. PubMed PMID: 16046590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overweight women with polycystic ovary syndrome have evidence of subclinical cardiovascular disease. AU - Meyer,C, AU - McGrath,B P, AU - Teede,H J, Y1 - 2005/07/26/ PY - 2005/7/28/pubmed PY - 2005/11/3/medline PY - 2005/7/28/entrez SP - 5711 EP - 6 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 90 IS - 10 N2 - CONTEXT: Polycystic ovary syndrome (PCOS) is associated with insulin resistance (IR) and the metabolic syndrome. There are no adequate data demonstrating significantly increased cardiovascular disease (CVD) mortality. In the absence of clinical outcome studies, surrogate markers of early CVD can provide insight into early CVD. OBJECTIVE: The aim of this study was to clarify whether overweight women with PCOS have an increased prevalence of cardiovascular risk factors and early CVD, compared with age- and body mass index-matched controls, to determine the contribution of PCOS per se to CVD status. DESIGN AND PATIENTS: This was a case control study of 100 overweight women with PCOS and 20 subjects of similar body mass index and age. MAIN OUTCOME MEASURES: Noninvasive markers of early CVD [carotid intimal media thickness, pulse wave velocity (PWV), and brachial arterial flow-mediated vasodilation] were measured. Metabolic parameters studied included insulin, glucose, C-reactive protein, lipids, and androgens. RESULTS: Subjects with PCOS had elevated testosterone (2.5 +/- 0.2 vs. 1.3 +/- 0.1 nmol/liter), dehydroepiandrosterone sulfate (4.9 +/- 0.3 vs. 3.6 +/- 0.4 mmol/liter), fasting insulin (19.6 +/- 1.4 vs. 6.8 +/- 0.8 microU/ml), and homeostasis model assessment of IR (4.1 +/- 0.3 vs. 1.3 +/- 0.2), compared with controls. In addition, those with PCOS had elevated cholesterol (5.1 +/- 0.1 vs. 4.6 +/- 0.2 mmol/liter) and triglycerides (1.4 +/- 0.1 vs. 0.9 +/- 0.1 mmol/liter), whereas there were no differences in either C-reactive protein or 24-h ambulatory blood pressure parameters. Subjects with PCOS also had increased arterial stiffness (PWV, 7.4 +/- 0.1 vs. 6.6 +/- 0.2 m/sec) and endothelial dysfunction (flow-mediated vasodilation, 9.8 +/- 0.4 vs. 13.3 +/- 0.9), compared with controls. There was no difference in mean intimal media thickness between the groups. Stepwise regression in PCOS subjects showed that IR and lipids were independent predictors of PWV. CONCLUSION: Overweight women with PCOS have increased cardiovascular risk factors and evidence of early CVD, compared with weight-matched controls, potentially related to IR. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/16046590/Overweight_women_with_polycystic_ovary_syndrome_have_evidence_of_subclinical_cardiovascular_disease_ DB - PRIME DP - Unbound Medicine ER -