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Dietary polyunsaturated fatty acids in asthma- and exercise-induced bronchoconstriction.
Eur J Clin Nutr 2005; 59(12):1335-46EJ

Abstract

Despite progress that has been made in the treatment of asthma, the prevalence and burden of this disease has continued to increase. While pharmacological treatment of asthma is usually highly effective, medications may have significant side effects or exhibit tachyphylaxis. Alternative therapies for treatment that reduce the dose requirements of pharmacological interventions would be beneficial, and could potentially reduce the public health burden of this disease. Ecological and temporal data suggest that dietary factors may have a role in recent increases in the prevalence of asthma. A possible contributing factor to the increased incidence of asthma in Western societies may be the consumption of a proinflammatory diet. In the typical Western diet, 20- to 25-fold more omega (n)-6 polyunsaturated fatty acids (PUFA) than n-3 PUFA are consumed, which promotes the release of proinflammatory arachidonic acid metabolites (leukotrienes and prostanoids). This review will analyze the evidence for the health effects of n-3 PUFA in asthma- and exercise-induced bronchoconstriction (EIB). While clinical data evaluating the effect of omega-3 fatty acid supplementation in asthma has been equivocal, it has recently been shown that fish oil supplementation, rich in n-3 PUFA, reduces airway narrowing, medication use, and proinflammatory mediator generation in nonatopic elite athletes with EIB. These findings are provocative and suggest that dietary fish oil supplementation may be a viable treatment modality and/or adjunct therapy in asthma and EIB.

Authors+Show Affiliations

Human Performance and Exercise Biochemistry Laboratory, Department of Kinesiology, Indiana University, Bloomington, 47401, USA. tmickleb@indiana.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16047026

Citation

Mickleborough, T D., and K W. Rundell. "Dietary Polyunsaturated Fatty Acids in Asthma- and Exercise-induced Bronchoconstriction." European Journal of Clinical Nutrition, vol. 59, no. 12, 2005, pp. 1335-46.
Mickleborough TD, Rundell KW. Dietary polyunsaturated fatty acids in asthma- and exercise-induced bronchoconstriction. Eur J Clin Nutr. 2005;59(12):1335-46.
Mickleborough, T. D., & Rundell, K. W. (2005). Dietary polyunsaturated fatty acids in asthma- and exercise-induced bronchoconstriction. European Journal of Clinical Nutrition, 59(12), pp. 1335-46.
Mickleborough TD, Rundell KW. Dietary Polyunsaturated Fatty Acids in Asthma- and Exercise-induced Bronchoconstriction. Eur J Clin Nutr. 2005;59(12):1335-46. PubMed PMID: 16047026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary polyunsaturated fatty acids in asthma- and exercise-induced bronchoconstriction. AU - Mickleborough,T D, AU - Rundell,K W, PY - 2005/7/28/pubmed PY - 2006/2/8/medline PY - 2005/7/28/entrez SP - 1335 EP - 46 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 IS - 12 N2 - Despite progress that has been made in the treatment of asthma, the prevalence and burden of this disease has continued to increase. While pharmacological treatment of asthma is usually highly effective, medications may have significant side effects or exhibit tachyphylaxis. Alternative therapies for treatment that reduce the dose requirements of pharmacological interventions would be beneficial, and could potentially reduce the public health burden of this disease. Ecological and temporal data suggest that dietary factors may have a role in recent increases in the prevalence of asthma. A possible contributing factor to the increased incidence of asthma in Western societies may be the consumption of a proinflammatory diet. In the typical Western diet, 20- to 25-fold more omega (n)-6 polyunsaturated fatty acids (PUFA) than n-3 PUFA are consumed, which promotes the release of proinflammatory arachidonic acid metabolites (leukotrienes and prostanoids). This review will analyze the evidence for the health effects of n-3 PUFA in asthma- and exercise-induced bronchoconstriction (EIB). While clinical data evaluating the effect of omega-3 fatty acid supplementation in asthma has been equivocal, it has recently been shown that fish oil supplementation, rich in n-3 PUFA, reduces airway narrowing, medication use, and proinflammatory mediator generation in nonatopic elite athletes with EIB. These findings are provocative and suggest that dietary fish oil supplementation may be a viable treatment modality and/or adjunct therapy in asthma and EIB. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16047026/Dietary_polyunsaturated_fatty_acids_in_asthma__and_exercise_induced_bronchoconstriction_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602250 DB - PRIME DP - Unbound Medicine ER -