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Case for folic acid and vitamin B12 fortification in Europe.
Semin Vasc Med. 2005 May; 5(2):156-62.SV

Abstract

The number of pregnancies affected by neural tube defects has been estimated to be 4000/year in Europe, with a higher prevalence in Celtic populations and in women of low socioeconomic status. Since the 1980s, it has been shown that supplementation with folic acid during the periconceptual period reduces the risk of neural tube defects in the fetus. However, in view of the period during which supplementation should be taken (< 4 weeks before conception until 8-10 weeks after) and the fact that in some countries 30-50% of pregnancies are unplanned, a public health initiative based solely on increasing dietary folate intake or recommendations on use of folic acid supplements is likely to be insufficient. Mandatory fortification has been started in 38 countries throughout the world. Several European countries have advocated mandatory flour folic acid fortification over the last 6 years, but none has introduced it. A recent public health decision in Hungary stimulated flour fortification on a voluntary basis, but it remains the only European country to take this action. Many European countries have deferred a decision to introduce fortification because of concerns about possible masking of vitamin B (12) deficiency. This review advocates a proposal for combined fortification of folic acid and vitamin B (12) to address possible hazards of fortification with folic acid alone.

Authors+Show Affiliations

Nutritional Epidemiology Unit-French Institute of Health and Medical Research, INSERM U 557, Paris.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16047267

Citation

Czernichow, Sébastien, et al. "Case for Folic Acid and Vitamin B12 Fortification in Europe." Seminars in Vascular Medicine, vol. 5, no. 2, 2005, pp. 156-62.
Czernichow S, Noisette N, Blacher J, et al. Case for folic acid and vitamin B12 fortification in Europe. Semin Vasc Med. 2005;5(2):156-62.
Czernichow, S., Noisette, N., Blacher, J., Galan, P., Mennen, L., Hercberg, S., & Ducimetière, P. (2005). Case for folic acid and vitamin B12 fortification in Europe. Seminars in Vascular Medicine, 5(2), 156-62.
Czernichow S, et al. Case for Folic Acid and Vitamin B12 Fortification in Europe. Semin Vasc Med. 2005;5(2):156-62. PubMed PMID: 16047267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case for folic acid and vitamin B12 fortification in Europe. AU - Czernichow,Sébastien, AU - Noisette,Nathalie, AU - Blacher,Jacques, AU - Galan,Pilar, AU - Mennen,Louise, AU - Hercberg,Serge, AU - Ducimetière,Pierre, PY - 2005/7/28/pubmed PY - 2005/9/30/medline PY - 2005/7/28/entrez SP - 156 EP - 62 JF - Seminars in vascular medicine JO - Semin Vasc Med VL - 5 IS - 2 N2 - The number of pregnancies affected by neural tube defects has been estimated to be 4000/year in Europe, with a higher prevalence in Celtic populations and in women of low socioeconomic status. Since the 1980s, it has been shown that supplementation with folic acid during the periconceptual period reduces the risk of neural tube defects in the fetus. However, in view of the period during which supplementation should be taken (< 4 weeks before conception until 8-10 weeks after) and the fact that in some countries 30-50% of pregnancies are unplanned, a public health initiative based solely on increasing dietary folate intake or recommendations on use of folic acid supplements is likely to be insufficient. Mandatory fortification has been started in 38 countries throughout the world. Several European countries have advocated mandatory flour folic acid fortification over the last 6 years, but none has introduced it. A recent public health decision in Hungary stimulated flour fortification on a voluntary basis, but it remains the only European country to take this action. Many European countries have deferred a decision to introduce fortification because of concerns about possible masking of vitamin B (12) deficiency. This review advocates a proposal for combined fortification of folic acid and vitamin B (12) to address possible hazards of fortification with folic acid alone. SN - 1528-9648 UR - https://www.unboundmedicine.com/medline/citation/16047267/Case_for_folic_acid_and_vitamin_B12_fortification_in_Europe_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=16047267.ui DB - PRIME DP - Unbound Medicine ER -