Tags

Type your tag names separated by a space and hit enter

Potential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsia.
Gynecol Endocrinol. 2005 Jul; 21(1):1-6.GE

Abstract

AIMS

To evaluate changes in lipid profile, serum levels of malondialdehyde (MDA) and lipoprotein(a) (Lp(a)) and placental MDA in preeclamptic women, and to evaluate the atherogenic role of these changes in the pathophysiology of pre-eclampsia.

METHOD

A cross-sectional study was performed in 20 normal pregnant women, 25 women with mild preeclampsia and 28 women with severe preeclampsia in the third trimester. MDA, which is the endproduct of lipid peroxidation, was measured in placental tissue by the thiobarbituric acid (TBA) method of Ohkawa and colleagues and in serum by the TBA method of Asakawa and Matsushita. Serum lipid levels were measured by with an autoanalyzer, serum apolipoprotein (Apo) A-I and Apo B were measured by nephelometric assay and serum Lp(a) level using a nephelometric agglutination assay method. In preeclamptic and normal pregnant women, multiple comparisons between groups were performed by one-way analysis of variance supplemented with Tukey's HSD post hoc test. The association between placental and serum concentrations among groups was analyzed using the Pearson correlation test.

RESULTS

Serum levels of MDA, Lp(a), total cholesterol, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and placental MDA were significantly higher, and high-density lipoprotein cholesterol (HDL-C) and Apo A-I levels were significantly lower, in severely preeclamptic and mildly preeclamptic women than in the normal pregnant women, but no difference was observed in Apo B among groups. Serum level of Lp(a) was positively correlated with body mass index in severely preeclamptic women (r=0.489, p=0.008). A significant positive correlation was also found between serum level of MDA and systolic blood pressure in women with severe preeclampsia (r=0.375, p=0.049).

CONCLUSIONS

Our findings suggest that high Lp(a), lipid peroxidation, LDL-C and TG, and low HDL-C and Apo A-I levels, are important risk factors for atherosclerosis among preeclamptic women.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, School of Medicine, Dicle University, Diyarbakir, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16048794

Citation

Bayhan, Gokhan, et al. "Potential Atherogenic Roles of Lipids, Lipoprotein(a) and Lipid Peroxidation in Preeclampsia." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 21, no. 1, 2005, pp. 1-6.
Bayhan G, Koçyigit Y, Atamer A, et al. Potential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsia. Gynecol Endocrinol. 2005;21(1):1-6.
Bayhan, G., Koçyigit, Y., Atamer, A., Atamer, Y., & Akkus, Z. (2005). Potential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsia. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 21(1), 1-6.
Bayhan G, et al. Potential Atherogenic Roles of Lipids, Lipoprotein(a) and Lipid Peroxidation in Preeclampsia. Gynecol Endocrinol. 2005;21(1):1-6. PubMed PMID: 16048794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsia. AU - Bayhan,Gokhan, AU - Koçyigit,Yuksel, AU - Atamer,Aytaç, AU - Atamer,Yildiz, AU - Akkus,Zeki, PY - 2005/7/29/pubmed PY - 2005/12/13/medline PY - 2005/7/29/entrez SP - 1 EP - 6 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 21 IS - 1 N2 - AIMS: To evaluate changes in lipid profile, serum levels of malondialdehyde (MDA) and lipoprotein(a) (Lp(a)) and placental MDA in preeclamptic women, and to evaluate the atherogenic role of these changes in the pathophysiology of pre-eclampsia. METHOD: A cross-sectional study was performed in 20 normal pregnant women, 25 women with mild preeclampsia and 28 women with severe preeclampsia in the third trimester. MDA, which is the endproduct of lipid peroxidation, was measured in placental tissue by the thiobarbituric acid (TBA) method of Ohkawa and colleagues and in serum by the TBA method of Asakawa and Matsushita. Serum lipid levels were measured by with an autoanalyzer, serum apolipoprotein (Apo) A-I and Apo B were measured by nephelometric assay and serum Lp(a) level using a nephelometric agglutination assay method. In preeclamptic and normal pregnant women, multiple comparisons between groups were performed by one-way analysis of variance supplemented with Tukey's HSD post hoc test. The association between placental and serum concentrations among groups was analyzed using the Pearson correlation test. RESULTS: Serum levels of MDA, Lp(a), total cholesterol, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and placental MDA were significantly higher, and high-density lipoprotein cholesterol (HDL-C) and Apo A-I levels were significantly lower, in severely preeclamptic and mildly preeclamptic women than in the normal pregnant women, but no difference was observed in Apo B among groups. Serum level of Lp(a) was positively correlated with body mass index in severely preeclamptic women (r=0.489, p=0.008). A significant positive correlation was also found between serum level of MDA and systolic blood pressure in women with severe preeclampsia (r=0.375, p=0.049). CONCLUSIONS: Our findings suggest that high Lp(a), lipid peroxidation, LDL-C and TG, and low HDL-C and Apo A-I levels, are important risk factors for atherosclerosis among preeclamptic women. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/16048794/Potential_atherogenic_roles_of_lipids_lipoprotein_a__and_lipid_peroxidation_in_preeclampsia_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590500097382 DB - PRIME DP - Unbound Medicine ER -