Citation
Etuaful, S, et al. "Efficacy of the Combination Rifampin-streptomycin in Preventing Growth of Mycobacterium Ulcerans in Early Lesions of Buruli Ulcer in Humans." Antimicrobial Agents and Chemotherapy, vol. 49, no. 8, 2005, pp. 3182-6.
Etuaful S, Carbonnelle B, Grosset J, et al. Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans. Antimicrob Agents Chemother. 2005;49(8):3182-6.
Etuaful, S., Carbonnelle, B., Grosset, J., Lucas, S., Horsfield, C., Phillips, R., Evans, M., Ofori-Adjei, D., Klustse, E., Owusu-Boateng, J., Amedofu, G. K., Awuah, P., Ampadu, E., Amofah, G., Asiedu, K., & Wansbrough-Jones, M. (2005). Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans. Antimicrobial Agents and Chemotherapy, 49(8), 3182-6.
Etuaful S, et al. Efficacy of the Combination Rifampin-streptomycin in Preventing Growth of Mycobacterium Ulcerans in Early Lesions of Buruli Ulcer in Humans. Antimicrob Agents Chemother. 2005;49(8):3182-6. PubMed PMID: 16048922.
TY - JOUR
T1 - Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans.
AU - Etuaful,S,
AU - Carbonnelle,B,
AU - Grosset,J,
AU - Lucas,S,
AU - Horsfield,C,
AU - Phillips,R,
AU - Evans,M,
AU - Ofori-Adjei,D,
AU - Klustse,E,
AU - Owusu-Boateng,J,
AU - Amedofu,G K,
AU - Awuah,P,
AU - Ampadu,E,
AU - Amofah,G,
AU - Asiedu,K,
AU - Wansbrough-Jones,M,
PY - 2005/7/29/pubmed
PY - 2005/9/20/medline
PY - 2005/7/29/entrez
SP - 3182
EP - 6
JF - Antimicrobial agents and chemotherapy
JO - Antimicrob Agents Chemother
VL - 49
IS - 8
N2 - Mycobacterium ulcerans disease is common in some humid tropical areas, particularly in parts of West Africa, and current management is by surgical excision of skin lesions ranging from early nodules to extensive ulcers (Buruli ulcer). Antibiotic therapy would be more accessible to patients in areas of Buruli ulcer endemicity. We report a study of the efficacy of antibiotics in converting early lesions (nodules and plaques) from culture positive to culture negative. Lesions were excised either immediately or after treatment with rifampin orally at 10 mg/kg of body weight and streptomycin intramuscularly at 15 mg/kg of body weight daily for 2, 4, 8, or 12 weeks and examined by quantitative bacterial culture, PCR, and histopathology for M. ulcerans. Lesions were measured during treatment. Five lesions excised without antibiotic treatment and five lesions treated with antibiotics for 2 weeks were culture positive, whereas three lesions treated for 4 weeks, five treated for 8 weeks, and three treated for 12 weeks were culture negative. No lesions became enlarged during antibiotic treatment, and most became smaller. Treatment with rifampin and streptomycin for 4 weeks or more inhibited growth of M. ulcerans in human tissue, and it provides a basis for proceeding to a trial of antibiotic therapy as an alternative to surgery for early M. ulcerans disease.
SN - 0066-4804
UR - https://www.unboundmedicine.com/medline/citation/16048922/Efficacy_of_the_combination_rifampin_streptomycin_in_preventing_growth_of_Mycobacterium_ulcerans_in_early_lesions_of_Buruli_ulcer_in_humans_
DB - PRIME
DP - Unbound Medicine
ER -
