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Use of multivitamins and prostate cancer mortality in a large cohort of US men.
Cancer Causes Control 2005; 16(6):643-50CC

Abstract

OBJECTIVE

To assess the association between the use of multivitamins and prostate cancer mortality.

METHODS

A total of 5585 deaths from prostate cancer were identified during 18 years of follow-up of 475,726 men who were cancer-free and provided complete information on multivitamin use at enrollment in the Cancer Prevention Study II (CPS-II) cohort in 1982. Cox proportional hazards modeling was used to measure the association between multivitamin use at baseline and death from prostate cancer and to adjust for potential confounders.

RESULTS

The death rate from prostate cancer was marginally higher among men who took multivitamins regularly (> or =15 times/month) compared to non-users (multivariate rate ratio=1.07, 95% CI: 0.99-1.15); this risk was statistically significant only for those multivitamin users who used no additional (vitamin A, C, or E) supplements (multivariate rate ratio=1.15, 95% CI: 1.05-1.26). In addition, risk was greatest during the initial four years of follow-up (1982-1986, multivariate rate ratio=1.12, 95 CI: 0.87-1.46).

CONCLUSIONS

Regular multivitamin use was associated with a small increase in prostate cancer death rates in our study, and this association was limited to a subgroup of users.

Authors+Show Affiliations

Department of Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road NE, Atlanta, GA 30329, USA. Victoria.Stevens@cancer.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16049802

Citation

Stevens, Victoria L., et al. "Use of Multivitamins and Prostate Cancer Mortality in a Large Cohort of US Men." Cancer Causes & Control : CCC, vol. 16, no. 6, 2005, pp. 643-50.
Stevens VL, McCullough ML, Diver WR, et al. Use of multivitamins and prostate cancer mortality in a large cohort of US men. Cancer Causes Control. 2005;16(6):643-50.
Stevens, V. L., McCullough, M. L., Diver, W. R., Rodriguez, C., Jacobs, E. J., Thun, M. J., & Calle, E. E. (2005). Use of multivitamins and prostate cancer mortality in a large cohort of US men. Cancer Causes & Control : CCC, 16(6), pp. 643-50.
Stevens VL, et al. Use of Multivitamins and Prostate Cancer Mortality in a Large Cohort of US Men. Cancer Causes Control. 2005;16(6):643-50. PubMed PMID: 16049802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of multivitamins and prostate cancer mortality in a large cohort of US men. AU - Stevens,Victoria L, AU - McCullough,Marjorie L, AU - Diver,W Ryan, AU - Rodriguez,Carmen, AU - Jacobs,Eric J, AU - Thun,Michael J, AU - Calle,Eugenia E, PY - 2004/10/05/received PY - 2005/01/11/accepted PY - 2005/7/29/pubmed PY - 2006/1/21/medline PY - 2005/7/29/entrez SP - 643 EP - 50 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 16 IS - 6 N2 - OBJECTIVE: To assess the association between the use of multivitamins and prostate cancer mortality. METHODS: A total of 5585 deaths from prostate cancer were identified during 18 years of follow-up of 475,726 men who were cancer-free and provided complete information on multivitamin use at enrollment in the Cancer Prevention Study II (CPS-II) cohort in 1982. Cox proportional hazards modeling was used to measure the association between multivitamin use at baseline and death from prostate cancer and to adjust for potential confounders. RESULTS: The death rate from prostate cancer was marginally higher among men who took multivitamins regularly (> or =15 times/month) compared to non-users (multivariate rate ratio=1.07, 95% CI: 0.99-1.15); this risk was statistically significant only for those multivitamin users who used no additional (vitamin A, C, or E) supplements (multivariate rate ratio=1.15, 95% CI: 1.05-1.26). In addition, risk was greatest during the initial four years of follow-up (1982-1986, multivariate rate ratio=1.12, 95 CI: 0.87-1.46). CONCLUSIONS: Regular multivitamin use was associated with a small increase in prostate cancer death rates in our study, and this association was limited to a subgroup of users. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/16049802/full_citation L2 - https://doi.org/10.1007/s10552-005-0384-5 DB - PRIME DP - Unbound Medicine ER -