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Use of multivitamins and prostate cancer mortality in a large cohort of US men.

Abstract

OBJECTIVE

To assess the association between the use of multivitamins and prostate cancer mortality.

METHODS

A total of 5585 deaths from prostate cancer were identified during 18 years of follow-up of 475,726 men who were cancer-free and provided complete information on multivitamin use at enrollment in the Cancer Prevention Study II (CPS-II) cohort in 1982. Cox proportional hazards modeling was used to measure the association between multivitamin use at baseline and death from prostate cancer and to adjust for potential confounders.

RESULTS

The death rate from prostate cancer was marginally higher among men who took multivitamins regularly (> or =15 times/month) compared to non-users (multivariate rate ratio=1.07, 95% CI: 0.99-1.15); this risk was statistically significant only for those multivitamin users who used no additional (vitamin A, C, or E) supplements (multivariate rate ratio=1.15, 95% CI: 1.05-1.26). In addition, risk was greatest during the initial four years of follow-up (1982-1986, multivariate rate ratio=1.12, 95 CI: 0.87-1.46).

CONCLUSIONS

Regular multivitamin use was associated with a small increase in prostate cancer death rates in our study, and this association was limited to a subgroup of users.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road NE, Atlanta, GA 30329, USA. Victoria.Stevens@cancer.org

    , , , , ,

    Source

    Cancer causes & control : CCC 16:6 2005 Aug pg 643-50

    MeSH

    Aged
    Cohort Studies
    Dietary Supplements
    Humans
    Male
    Middle Aged
    Mortality
    Prostatic Neoplasms
    Risk Factors
    Survival Rate
    United States
    Vitamins

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    16049802

    Citation

    Stevens, Victoria L., et al. "Use of Multivitamins and Prostate Cancer Mortality in a Large Cohort of US Men." Cancer Causes & Control : CCC, vol. 16, no. 6, 2005, pp. 643-50.
    Stevens VL, McCullough ML, Diver WR, et al. Use of multivitamins and prostate cancer mortality in a large cohort of US men. Cancer Causes Control. 2005;16(6):643-50.
    Stevens, V. L., McCullough, M. L., Diver, W. R., Rodriguez, C., Jacobs, E. J., Thun, M. J., & Calle, E. E. (2005). Use of multivitamins and prostate cancer mortality in a large cohort of US men. Cancer Causes & Control : CCC, 16(6), pp. 643-50.
    Stevens VL, et al. Use of Multivitamins and Prostate Cancer Mortality in a Large Cohort of US Men. Cancer Causes Control. 2005;16(6):643-50. PubMed PMID: 16049802.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Use of multivitamins and prostate cancer mortality in a large cohort of US men. AU - Stevens,Victoria L, AU - McCullough,Marjorie L, AU - Diver,W Ryan, AU - Rodriguez,Carmen, AU - Jacobs,Eric J, AU - Thun,Michael J, AU - Calle,Eugenia E, PY - 2004/10/05/received PY - 2005/01/11/accepted PY - 2005/7/29/pubmed PY - 2006/1/21/medline PY - 2005/7/29/entrez SP - 643 EP - 50 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 16 IS - 6 N2 - OBJECTIVE: To assess the association between the use of multivitamins and prostate cancer mortality. METHODS: A total of 5585 deaths from prostate cancer were identified during 18 years of follow-up of 475,726 men who were cancer-free and provided complete information on multivitamin use at enrollment in the Cancer Prevention Study II (CPS-II) cohort in 1982. Cox proportional hazards modeling was used to measure the association between multivitamin use at baseline and death from prostate cancer and to adjust for potential confounders. RESULTS: The death rate from prostate cancer was marginally higher among men who took multivitamins regularly (> or =15 times/month) compared to non-users (multivariate rate ratio=1.07, 95% CI: 0.99-1.15); this risk was statistically significant only for those multivitamin users who used no additional (vitamin A, C, or E) supplements (multivariate rate ratio=1.15, 95% CI: 1.05-1.26). In addition, risk was greatest during the initial four years of follow-up (1982-1986, multivariate rate ratio=1.12, 95 CI: 0.87-1.46). CONCLUSIONS: Regular multivitamin use was associated with a small increase in prostate cancer death rates in our study, and this association was limited to a subgroup of users. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/16049802/full_citation L2 - https://doi.org/10.1007/s10552-005-0384-5 DB - PRIME DP - Unbound Medicine ER -