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Increased extracellular collagen matrix in myocardial sleeves of pulmonary veins: an additional mechanism facilitating repetitive rapid activities in chronic pacing-induced sustained atrial fibrillation.
J Cardiovasc Electrophysiol. 2005 Jul; 16(7):753-9.JC

Abstract

Increased ECM in canine PVs.

INTRODUCTION

Cell uncoupling due to fibrosis or increased extracellular collagen matrix (ECM) affects the formation of ectopic focal activity. Whether or not the increase of ECM also exists in the pulmonary veins (PVs) with rapid atrial pacing is unknown. We sought to test the hypothesis that in chronic atrial pacing dogs with sustained atrial fibrillation (AF), the amount of ECM was increased in both atria and the PVs.

METHODS AND RESULTS

We induced sustained AF in dogs by rapid atrial pacing. Computerized mapping techniques were used to map both atria and the PVs. We also used histological assessment to quantify the amount of ECM. After 118+/-24 days of rapid atrial pacing, sustained AF was induced in 7 dogs. Repetitive rapid activities (RRAs) either continuously or intermittently arose from the PVs during sustained AF. Histological study shows that there was no fibrosis in both atrial free walls and the PVs. However, the amount of ECM was increased in these regions. The mean ECM surface area fraction at each region in the dogs with sustained AF was all significantly higher compared to the corresponding region in normal dogs. Similarly, the heterogeneity of the ECM surface area fraction at each region in the dogs with sustained AF was also all significantly higher compared to normal dogs.

CONCLUSIONS

In chronic atrial pacing-induced sustained AF, structural remodeling (i.e., inhomogeneous increase of ECM) also involves the PVs. Reduced coupling of the myocytes in the PV due to histological changes may provide an additional mechanism facilitating RRAs.

Authors+Show Affiliations

Chiu YT
Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Wu TJ
No affiliation info available
Wei HJ
No affiliation info available
Cheng CC
No affiliation info available
Lin NN
No affiliation info available
Chen YT
No affiliation info available
Ting CT
No affiliation info available

MeSH

AnimalsAtrial FibrillationAtrial FunctionCardiac Pacing, ArtificialCollagenDogsExtracellular MatrixMyocardiumPulmonary VeinsTissue Distribution

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16050834

Citation

Chiu, Yung-Tsung, et al. "Increased Extracellular Collagen Matrix in Myocardial Sleeves of Pulmonary Veins: an Additional Mechanism Facilitating Repetitive Rapid Activities in Chronic Pacing-induced Sustained Atrial Fibrillation." Journal of Cardiovascular Electrophysiology, vol. 16, no. 7, 2005, pp. 753-9.
Chiu YT, Wu TJ, Wei HJ, et al. Increased extracellular collagen matrix in myocardial sleeves of pulmonary veins: an additional mechanism facilitating repetitive rapid activities in chronic pacing-induced sustained atrial fibrillation. J Cardiovasc Electrophysiol. 2005;16(7):753-9.
Chiu, Y. T., Wu, T. J., Wei, H. J., Cheng, C. C., Lin, N. N., Chen, Y. T., & Ting, C. T. (2005). Increased extracellular collagen matrix in myocardial sleeves of pulmonary veins: an additional mechanism facilitating repetitive rapid activities in chronic pacing-induced sustained atrial fibrillation. Journal of Cardiovascular Electrophysiology, 16(7), 753-9.
Chiu YT, et al. Increased Extracellular Collagen Matrix in Myocardial Sleeves of Pulmonary Veins: an Additional Mechanism Facilitating Repetitive Rapid Activities in Chronic Pacing-induced Sustained Atrial Fibrillation. J Cardiovasc Electrophysiol. 2005;16(7):753-9. PubMed PMID: 16050834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased extracellular collagen matrix in myocardial sleeves of pulmonary veins: an additional mechanism facilitating repetitive rapid activities in chronic pacing-induced sustained atrial fibrillation. AU - Chiu,Yung-Tsung, AU - Wu,Tsu-Juey, AU - Wei,Hao-Ji, AU - Cheng,Ching-Chang, AU - Lin,Nai-Nu, AU - Chen,Ying-Tsung, AU - Ting,Chih-Tai, PY - 2005/7/30/pubmed PY - 2005/10/28/medline PY - 2005/7/30/entrez SP - 753 EP - 9 JF - Journal of cardiovascular electrophysiology JO - J Cardiovasc Electrophysiol VL - 16 IS - 7 N2 - UNLABELLED: Increased ECM in canine PVs. INTRODUCTION: Cell uncoupling due to fibrosis or increased extracellular collagen matrix (ECM) affects the formation of ectopic focal activity. Whether or not the increase of ECM also exists in the pulmonary veins (PVs) with rapid atrial pacing is unknown. We sought to test the hypothesis that in chronic atrial pacing dogs with sustained atrial fibrillation (AF), the amount of ECM was increased in both atria and the PVs. METHODS AND RESULTS: We induced sustained AF in dogs by rapid atrial pacing. Computerized mapping techniques were used to map both atria and the PVs. We also used histological assessment to quantify the amount of ECM. After 118+/-24 days of rapid atrial pacing, sustained AF was induced in 7 dogs. Repetitive rapid activities (RRAs) either continuously or intermittently arose from the PVs during sustained AF. Histological study shows that there was no fibrosis in both atrial free walls and the PVs. However, the amount of ECM was increased in these regions. The mean ECM surface area fraction at each region in the dogs with sustained AF was all significantly higher compared to the corresponding region in normal dogs. Similarly, the heterogeneity of the ECM surface area fraction at each region in the dogs with sustained AF was also all significantly higher compared to normal dogs. CONCLUSIONS: In chronic atrial pacing-induced sustained AF, structural remodeling (i.e., inhomogeneous increase of ECM) also involves the PVs. Reduced coupling of the myocytes in the PV due to histological changes may provide an additional mechanism facilitating RRAs. SN - 1045-3873 UR - https://www.unboundmedicine.com/medline/citation/16050834/Increased_extracellular_collagen_matrix_in_myocardial_sleeves_of_pulmonary_veins:_an_additional_mechanism_facilitating_repetitive_rapid_activities_in_chronic_pacing_induced_sustained_atrial_fibrillation_ DB - PRIME DP - Unbound Medicine ER -