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[Cannabinoids in multiple sclerosis -- therapeutically reasonable?].
Fortschr Neurol Psychiatr. 2005 Aug; 73(8):463-9.FN

Abstract

For centuries extracts from the Cannabis sativa plant have been used for recreational use and as remedies. Anecdotal reports from patients with multiple sclerosis (MS) experiencing relief of their spasticity and pain after smoking marihuana have prompted discussions about a potential therapeutic application of cannabis preparations in MS. Only recently the first large, multicenter, double-blind, placebo controlled study was conducted evaluating the use of cannabinoids for treatment of spasticity and other symptoms related to MS. Based on this trial and previous uncontrolled observations together with insights from basic research and animal experiments there is reasonable evidence for the therapeutical employment of cannabinoids in the treatment of MS related symptoms. Furthermore, data are arising that cannabinoids have immunomodulatory and neuroprotective properties. However, results from clinical trials do not allow the recommendation for the general use of cannabinoids in MS. This article summarizes the present knowledge of clinical and experimental research regarding the therapeutic potential of cannabinoids for the treatment of MS.

Authors+Show Affiliations

Neurologische Klinik mit Klinischer Neurophysiologie, Medizinische Hochschule Hannover. trebst.corinna@mh-hannover.deNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

16052440

Citation

Trebst, C, and M Stangel. "[Cannabinoids in Multiple Sclerosis -- Therapeutically Reasonable?]." Fortschritte Der Neurologie-Psychiatrie, vol. 73, no. 8, 2005, pp. 463-9.
Trebst C, Stangel M. [Cannabinoids in multiple sclerosis -- therapeutically reasonable?]. Fortschr Neurol Psychiatr. 2005;73(8):463-9.
Trebst, C., & Stangel, M. (2005). [Cannabinoids in multiple sclerosis -- therapeutically reasonable?]. Fortschritte Der Neurologie-Psychiatrie, 73(8), 463-9.
Trebst C, Stangel M. [Cannabinoids in Multiple Sclerosis -- Therapeutically Reasonable?]. Fortschr Neurol Psychiatr. 2005;73(8):463-9. PubMed PMID: 16052440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cannabinoids in multiple sclerosis -- therapeutically reasonable?]. AU - Trebst,C, AU - Stangel,M, PY - 2005/7/30/pubmed PY - 2005/9/15/medline PY - 2005/7/30/entrez SP - 463 EP - 9 JF - Fortschritte der Neurologie-Psychiatrie JO - Fortschr Neurol Psychiatr VL - 73 IS - 8 N2 - For centuries extracts from the Cannabis sativa plant have been used for recreational use and as remedies. Anecdotal reports from patients with multiple sclerosis (MS) experiencing relief of their spasticity and pain after smoking marihuana have prompted discussions about a potential therapeutic application of cannabis preparations in MS. Only recently the first large, multicenter, double-blind, placebo controlled study was conducted evaluating the use of cannabinoids for treatment of spasticity and other symptoms related to MS. Based on this trial and previous uncontrolled observations together with insights from basic research and animal experiments there is reasonable evidence for the therapeutical employment of cannabinoids in the treatment of MS related symptoms. Furthermore, data are arising that cannabinoids have immunomodulatory and neuroprotective properties. However, results from clinical trials do not allow the recommendation for the general use of cannabinoids in MS. This article summarizes the present knowledge of clinical and experimental research regarding the therapeutic potential of cannabinoids for the treatment of MS. SN - 0720-4299 UR - https://www.unboundmedicine.com/medline/citation/16052440/[Cannabinoids_in_multiple_sclerosis____therapeutically_reasonable]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-830119 DB - PRIME DP - Unbound Medicine ER -