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Protein source tryptophan versus pharmaceutical grade tryptophan as an efficacious treatment for chronic insomnia.

Abstract

BACKGROUND

Intact protein rich in tryptophan was not seen as an alternative to pharmaceutical grade tryptophan since protein also contains large neutral amino acids (LNAAs) that compete for transport sites across the blood-brain barrier (BBB). Deoiled gourd seed (an extremely rich source of tryptophan-22 mg tryptophan/1 g protein) was combined with glucose, a carbohydrate that reduces serum levels of competing LNAAs which was then compared to pharmaceutical grade tryptophan with carbohydrate as well as carbohydrate alone.

METHOD

Objective and subjective measures of sleep were employed to measure changes in sleep as part of a double blind placebo controlled study where subjects were randomly assigned to one of three conditions: (1) Protein source tryptophan (deoiled gourd seed) in combination with carbohydrate; (2) pharmaceutical grade tryptophan in combination with carbohydrate; (3) carbohydrate alone.

SUBJECTS

Out of 57 subjects 49 of those who began the study completed the three week protocol.

RESULTS

Protein source tryptophan with carbohydrate and pharmaceutical grade tryptophan, but not carbohydrate alone, resulted in significant improvement on subjective and objective measures of insomnia. Protein source tryptophan with carbohydrate alone proved effective in significantly reducing time awake during the night.

CONCLUSION

Protein source tryptophan is comparable to pharmaceutical grade tryptophan for the treatment of insomnia.

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  • Authors+Show Affiliations

    ,

    Biosential Inc., 1543 Bayview Avenue, Suite 346, Toronto, Ontario M4G 3B5, Canada. craighudson@biosential.com

    , ,

    Source

    Nutritional neuroscience 8:2 2005 Apr pg 121-7

    MeSH

    Avena
    Biological Availability
    Blood-Brain Barrier
    Chronic Disease
    Cucurbita
    Dietary Carbohydrates
    Dietary Proteins
    Double-Blind Method
    Female
    Humans
    Male
    Middle Aged
    Pharmaceutical Preparations
    Placebos
    Seeds
    Sleep
    Sleep Initiation and Maintenance Disorders
    Time Factors
    Tryptophan
    Twin Studies as Topic
    Wakefulness

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    16053244

    Citation

    Hudson, Craig, et al. "Protein Source Tryptophan Versus Pharmaceutical Grade Tryptophan as an Efficacious Treatment for Chronic Insomnia." Nutritional Neuroscience, vol. 8, no. 2, 2005, pp. 121-7.
    Hudson C, Hudson SP, Hecht T, et al. Protein source tryptophan versus pharmaceutical grade tryptophan as an efficacious treatment for chronic insomnia. Nutr Neurosci. 2005;8(2):121-7.
    Hudson, C., Hudson, S. P., Hecht, T., & MacKenzie, J. (2005). Protein source tryptophan versus pharmaceutical grade tryptophan as an efficacious treatment for chronic insomnia. Nutritional Neuroscience, 8(2), pp. 121-7.
    Hudson C, et al. Protein Source Tryptophan Versus Pharmaceutical Grade Tryptophan as an Efficacious Treatment for Chronic Insomnia. Nutr Neurosci. 2005;8(2):121-7. PubMed PMID: 16053244.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Protein source tryptophan versus pharmaceutical grade tryptophan as an efficacious treatment for chronic insomnia. AU - Hudson,Craig, AU - Hudson,Susan Patricia, AU - Hecht,Tracy, AU - MacKenzie,Joan, PY - 2005/8/2/pubmed PY - 2005/9/13/medline PY - 2005/8/2/entrez SP - 121 EP - 7 JF - Nutritional neuroscience JO - Nutr Neurosci VL - 8 IS - 2 N2 - BACKGROUND: Intact protein rich in tryptophan was not seen as an alternative to pharmaceutical grade tryptophan since protein also contains large neutral amino acids (LNAAs) that compete for transport sites across the blood-brain barrier (BBB). Deoiled gourd seed (an extremely rich source of tryptophan-22 mg tryptophan/1 g protein) was combined with glucose, a carbohydrate that reduces serum levels of competing LNAAs which was then compared to pharmaceutical grade tryptophan with carbohydrate as well as carbohydrate alone. METHOD: Objective and subjective measures of sleep were employed to measure changes in sleep as part of a double blind placebo controlled study where subjects were randomly assigned to one of three conditions: (1) Protein source tryptophan (deoiled gourd seed) in combination with carbohydrate; (2) pharmaceutical grade tryptophan in combination with carbohydrate; (3) carbohydrate alone. SUBJECTS: Out of 57 subjects 49 of those who began the study completed the three week protocol. RESULTS: Protein source tryptophan with carbohydrate and pharmaceutical grade tryptophan, but not carbohydrate alone, resulted in significant improvement on subjective and objective measures of insomnia. Protein source tryptophan with carbohydrate alone proved effective in significantly reducing time awake during the night. CONCLUSION: Protein source tryptophan is comparable to pharmaceutical grade tryptophan for the treatment of insomnia. SN - 1028-415X UR - https://www.unboundmedicine.com/medline/citation/16053244/full_citation L2 - http://www.tandfonline.com/doi/full/10.1080/10284150500069561 DB - PRIME DP - Unbound Medicine ER -