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Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning.
Behav Brain Res. 2005 Oct 14; 164(1):128-31.BB

Abstract

Estrogen has marked effects on hippocampal synaptic plasticity. We demonstrate that male and female 3-month-old beta estrogen receptor knockout (BERKO) mice show profound memory impairment in a hippocampus-mediated fear-conditioning paradigm. Subsequently, hippocampal slices prepared from behaviorally naive female BERKO mice were examined electrophysiologically. These were found to have robust synaptic deficits, compared to slices from age-matched wild type controls, both in terms of their input-output curves and their expression of long-term-potentiation in area CA1. This report provides the first concrete evidence of significant hippocampal synaptic plasticity and memory deficits in the BERKO mouse.

Authors+Show Affiliations

Wyeth Research, Discovery Neuroscience, CN8000, Princeton, NJ 08543, USA. Daym1@wyeth.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16054246

Citation

Day, Mark, et al. "Beta Estrogen Receptor Knockout (BERKO) Mice Present Attenuated Hippocampal CA1 Long-term Potentiation and Related Memory Deficits in Contextual Fear Conditioning." Behavioural Brain Research, vol. 164, no. 1, 2005, pp. 128-31.
Day M, Sung A, Logue S, et al. Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning. Behav Brain Res. 2005;164(1):128-31.
Day, M., Sung, A., Logue, S., Bowlby, M., & Arias, R. (2005). Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning. Behavioural Brain Research, 164(1), 128-31.
Day M, et al. Beta Estrogen Receptor Knockout (BERKO) Mice Present Attenuated Hippocampal CA1 Long-term Potentiation and Related Memory Deficits in Contextual Fear Conditioning. Behav Brain Res. 2005 Oct 14;164(1):128-31. PubMed PMID: 16054246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning. AU - Day,Mark, AU - Sung,Amy, AU - Logue,Sheree, AU - Bowlby,Mark, AU - Arias,Robert, PY - 2005/03/14/received PY - 2005/05/04/revised PY - 2005/05/09/accepted PY - 2005/8/2/pubmed PY - 2006/1/21/medline PY - 2005/8/2/entrez SP - 128 EP - 31 JF - Behavioural brain research JO - Behav. Brain Res. VL - 164 IS - 1 N2 - Estrogen has marked effects on hippocampal synaptic plasticity. We demonstrate that male and female 3-month-old beta estrogen receptor knockout (BERKO) mice show profound memory impairment in a hippocampus-mediated fear-conditioning paradigm. Subsequently, hippocampal slices prepared from behaviorally naive female BERKO mice were examined electrophysiologically. These were found to have robust synaptic deficits, compared to slices from age-matched wild type controls, both in terms of their input-output curves and their expression of long-term-potentiation in area CA1. This report provides the first concrete evidence of significant hippocampal synaptic plasticity and memory deficits in the BERKO mouse. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/16054246/Beta_estrogen_receptor_knockout__BERKO__mice_present_attenuated_hippocampal_CA1_long_term_potentiation_and_related_memory_deficits_in_contextual_fear_conditioning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(05)00235-4 DB - PRIME DP - Unbound Medicine ER -