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Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning.
Behav Brain Res 2005; 164(1):128-31BB

Abstract

Estrogen has marked effects on hippocampal synaptic plasticity. We demonstrate that male and female 3-month-old beta estrogen receptor knockout (BERKO) mice show profound memory impairment in a hippocampus-mediated fear-conditioning paradigm. Subsequently, hippocampal slices prepared from behaviorally naive female BERKO mice were examined electrophysiologically. These were found to have robust synaptic deficits, compared to slices from age-matched wild type controls, both in terms of their input-output curves and their expression of long-term-potentiation in area CA1. This report provides the first concrete evidence of significant hippocampal synaptic plasticity and memory deficits in the BERKO mouse.

Authors+Show Affiliations

Wyeth Research, Discovery Neuroscience, CN8000, Princeton, NJ 08543, USA. Daym1@wyeth.com

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16054246

Citation

Day, Mark, et al. "Beta Estrogen Receptor Knockout (BERKO) Mice Present Attenuated Hippocampal CA1 Long-term Potentiation and Related Memory Deficits in Contextual Fear Conditioning." Behavioural Brain Research, vol. 164, no. 1, 2005, pp. 128-31.
Day M, Sung A, Logue S, et al. Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning. Behav Brain Res. 2005;164(1):128-31.
Day, M., Sung, A., Logue, S., Bowlby, M., & Arias, R. (2005). Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning. Behavioural Brain Research, 164(1), pp. 128-31.
Day M, et al. Beta Estrogen Receptor Knockout (BERKO) Mice Present Attenuated Hippocampal CA1 Long-term Potentiation and Related Memory Deficits in Contextual Fear Conditioning. Behav Brain Res. 2005 Oct 14;164(1):128-31. PubMed PMID: 16054246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning. AU - Day,Mark, AU - Sung,Amy, AU - Logue,Sheree, AU - Bowlby,Mark, AU - Arias,Robert, PY - 2005/03/14/received PY - 2005/05/04/revised PY - 2005/05/09/accepted PY - 2005/8/2/pubmed PY - 2006/1/21/medline PY - 2005/8/2/entrez SP - 128 EP - 31 JF - Behavioural brain research JO - Behav. Brain Res. VL - 164 IS - 1 N2 - Estrogen has marked effects on hippocampal synaptic plasticity. We demonstrate that male and female 3-month-old beta estrogen receptor knockout (BERKO) mice show profound memory impairment in a hippocampus-mediated fear-conditioning paradigm. Subsequently, hippocampal slices prepared from behaviorally naive female BERKO mice were examined electrophysiologically. These were found to have robust synaptic deficits, compared to slices from age-matched wild type controls, both in terms of their input-output curves and their expression of long-term-potentiation in area CA1. This report provides the first concrete evidence of significant hippocampal synaptic plasticity and memory deficits in the BERKO mouse. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/16054246/Beta_estrogen_receptor_knockout__BERKO__mice_present_attenuated_hippocampal_CA1_long_term_potentiation_and_related_memory_deficits_in_contextual_fear_conditioning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(05)00235-4 DB - PRIME DP - Unbound Medicine ER -