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The IGF-system is not affected by a twofold change in protein intake in patients with type 1 diabetes.
Growth Horm IGF Res 2005; 15(4):304-10GH

Abstract

OBJECTIVE

In type 1 diabetes the circulating IGF-system is altered with low IGF-I and changes in levels of IGF-binding proteins (IGFBPs) which may be of importance for the development of diabetes complications. Our aim was to study if IGF-I, as supported by experimental data in animals, can be affected by dietary protein intake.

DESIGN AND METHODS

Twelve patients with type 1 diabetes, age 37.5+/-10.0 years (mean+/-SD), diabetes duration 20.1+/-9.3 years and HbA1c 6.3+/-0.6% were allocated to isocaloric diets with either low normal protein content (LNP), (10 E%; 0.9 g protein/kg body weight) or high normal protein content (HNP) (20 E%; 1.8 g protein/kg body weight) in an open randomised cross-over study. Each diet was taken for 10 days with a wash-out period of 11 days in between. Circulating levels of total and free IGF-I and -II, IGFBP-1, -2 and -3 and GH-binding protein (GHBP) as well as ghrelin were measured with validated in-house immunoassays.

RESULTS

At day 10, urinary urea excretion was 320+/-75 mmol/24h during LNP diet compared with 654+/-159 mmol/24h during HNP diet (p<0.001). There were no changes in body weight or glycaemic control between the diets. Fasting levels of total IGF-I were 121+/-33 microg/L after LNP and 117+/-28 microg/L after HNP diet (ns) and the corresponding concentrations of IGFBP-1 were 142(141) and 132(157)mug/L [median (IQR)] (ns). There were no differences in plasma concentrations of total IGF-II, free IGF-I and -II, IGFBP-3, GHBP and ghrelin, whereas a small difference was found for IGFBP-2 (302+/-97 vs. 263+/-66 microg/L; LNP vs. HNP; p<0.04).

CONCLUSIONS

A twofold change of the dietary protein intake does not influence the altered circulating IGF-system in type 1 diabetes. In order to affect the IGF-system other interventions must be used.

Authors+Show Affiliations

Division of Internal Medicine, Department of Medicine and Care, Diabetes Research Centre, Faculty of Health Sciences, SE-581 83 Linköping University, Linköping, Sweden. christina.hedman@lio.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16054412

Citation

Hedman, Christina A., et al. "The IGF-system Is Not Affected By a Twofold Change in Protein Intake in Patients With Type 1 Diabetes." Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society, vol. 15, no. 4, 2005, pp. 304-10.
Hedman CA, Frystyk J, Fridell K, et al. The IGF-system is not affected by a twofold change in protein intake in patients with type 1 diabetes. Growth Horm IGF Res. 2005;15(4):304-10.
Hedman, C. A., Frystyk, J., Fridell, K., Jönsson, A., Flyvbjerg, A., Lindström, T., & Arnqvist, H. J. (2005). The IGF-system is not affected by a twofold change in protein intake in patients with type 1 diabetes. Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society, 15(4), pp. 304-10.
Hedman CA, et al. The IGF-system Is Not Affected By a Twofold Change in Protein Intake in Patients With Type 1 Diabetes. Growth Horm IGF Res. 2005;15(4):304-10. PubMed PMID: 16054412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The IGF-system is not affected by a twofold change in protein intake in patients with type 1 diabetes. AU - Hedman,Christina A, AU - Frystyk,Jan, AU - Fridell,Karin, AU - Jönsson,Anna, AU - Flyvbjerg,Allan, AU - Lindström,Torbjörn, AU - Arnqvist,Hans J, PY - 2005/02/04/received PY - 2005/06/06/revised PY - 2005/06/08/accepted PY - 2005/8/2/pubmed PY - 2005/10/21/medline PY - 2005/8/2/entrez SP - 304 EP - 10 JF - Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society JO - Growth Horm. IGF Res. VL - 15 IS - 4 N2 - OBJECTIVE: In type 1 diabetes the circulating IGF-system is altered with low IGF-I and changes in levels of IGF-binding proteins (IGFBPs) which may be of importance for the development of diabetes complications. Our aim was to study if IGF-I, as supported by experimental data in animals, can be affected by dietary protein intake. DESIGN AND METHODS: Twelve patients with type 1 diabetes, age 37.5+/-10.0 years (mean+/-SD), diabetes duration 20.1+/-9.3 years and HbA1c 6.3+/-0.6% were allocated to isocaloric diets with either low normal protein content (LNP), (10 E%; 0.9 g protein/kg body weight) or high normal protein content (HNP) (20 E%; 1.8 g protein/kg body weight) in an open randomised cross-over study. Each diet was taken for 10 days with a wash-out period of 11 days in between. Circulating levels of total and free IGF-I and -II, IGFBP-1, -2 and -3 and GH-binding protein (GHBP) as well as ghrelin were measured with validated in-house immunoassays. RESULTS: At day 10, urinary urea excretion was 320+/-75 mmol/24h during LNP diet compared with 654+/-159 mmol/24h during HNP diet (p<0.001). There were no changes in body weight or glycaemic control between the diets. Fasting levels of total IGF-I were 121+/-33 microg/L after LNP and 117+/-28 microg/L after HNP diet (ns) and the corresponding concentrations of IGFBP-1 were 142(141) and 132(157)mug/L [median (IQR)] (ns). There were no differences in plasma concentrations of total IGF-II, free IGF-I and -II, IGFBP-3, GHBP and ghrelin, whereas a small difference was found for IGFBP-2 (302+/-97 vs. 263+/-66 microg/L; LNP vs. HNP; p<0.04). CONCLUSIONS: A twofold change of the dietary protein intake does not influence the altered circulating IGF-system in type 1 diabetes. In order to affect the IGF-system other interventions must be used. SN - 1096-6374 UR - https://www.unboundmedicine.com/medline/citation/16054412/The_IGF_system_is_not_affected_by_a_twofold_change_in_protein_intake_in_patients_with_type_1_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1096-6374(05)00071-7 DB - PRIME DP - Unbound Medicine ER -