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Alcohol drinking and risk of hospitalization for heart failure with and without associated coronary artery disease.
Am J Cardiol. 2005 Aug 01; 96(3):346-51.AJ

Abstract

Myocardial damage from heavy alcohol intake can cause the heart failure (HF) syndrome, but the relation of lighter alcohol intake to HF has rarely been studied. We examined the risk of HF hospitalization among 126,236 subjects who supplied data about alcohol during health examinations from 1978 to 1985. Among 2,594 subjects who were subsequently hospitalized for HF, record review established an association between coronary artery disease (CAD) and HF (CAD-HF) in 1,559 patients. Among the remaining 1,035 subjects who had HF (non-CAD-HF), we attempted determination of preponderant etiologic and contributory factors. Analyses used Cox models that were controlled for 7 covariates, with usual alcohol intake studied categorically compared with that in subjects who did not drink alcohol. Heavier drinkers (> or =3 drinks/day) but not light to moderate drinkers had increased risk of non-CAD-HF; e.g., relative risk for subjects who reported > or =6 drinks/day was 1.7 (95% confidence interval 1.1 to 2.6). This association of non-CAD-HF with heavy drinking was limited to subsets with cardiomyopathy or of unclear preponderant etiology. Alcohol drinking was inversely related to risk of CAD-HF (e.g., at 1 to 2 drinks/day, relative risk 0.6, 95% confidence interval 0.5 to 0.7), with consistency across subgroups of age, gender, ethnicity, education, smoking status, interval to diagnosis, and presence or absence of baseline heart disease or systemic hypertension. Moderate drinking was inversely related to non-CAD-HF only in subjects who had diabetes mellitus (n = 252). In conclusion, heavy, but not light, alcohol drinking is associated with increased risk of non-CAD-HF and that apparent protection by alcohol drinking against CAD-HF risk provides confirmation of a protective effect of alcohol against CAD.

Authors+Show Affiliations

Kaiser Permanente Medical Care Program, Oakland, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16054455

Citation

Klatsky, Arthur L., et al. "Alcohol Drinking and Risk of Hospitalization for Heart Failure With and Without Associated Coronary Artery Disease." The American Journal of Cardiology, vol. 96, no. 3, 2005, pp. 346-51.
Klatsky AL, Chartier D, Udaltsova N, et al. Alcohol drinking and risk of hospitalization for heart failure with and without associated coronary artery disease. Am J Cardiol. 2005;96(3):346-51.
Klatsky, A. L., Chartier, D., Udaltsova, N., Gronningen, S., Brar, S., Friedman, G. D., & Lundstrom, R. J. (2005). Alcohol drinking and risk of hospitalization for heart failure with and without associated coronary artery disease. The American Journal of Cardiology, 96(3), 346-51.
Klatsky AL, et al. Alcohol Drinking and Risk of Hospitalization for Heart Failure With and Without Associated Coronary Artery Disease. Am J Cardiol. 2005 Aug 1;96(3):346-51. PubMed PMID: 16054455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol drinking and risk of hospitalization for heart failure with and without associated coronary artery disease. AU - Klatsky,Arthur L, AU - Chartier,Douglas, AU - Udaltsova,Natalia, AU - Gronningen,Sharon, AU - Brar,Somjot, AU - Friedman,Gary D, AU - Lundstrom,Robert J, PY - 2005/01/26/received PY - 2005/03/23/revised PY - 2005/03/23/accepted PY - 2005/8/2/pubmed PY - 2005/9/15/medline PY - 2005/8/2/entrez SP - 346 EP - 51 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 96 IS - 3 N2 - Myocardial damage from heavy alcohol intake can cause the heart failure (HF) syndrome, but the relation of lighter alcohol intake to HF has rarely been studied. We examined the risk of HF hospitalization among 126,236 subjects who supplied data about alcohol during health examinations from 1978 to 1985. Among 2,594 subjects who were subsequently hospitalized for HF, record review established an association between coronary artery disease (CAD) and HF (CAD-HF) in 1,559 patients. Among the remaining 1,035 subjects who had HF (non-CAD-HF), we attempted determination of preponderant etiologic and contributory factors. Analyses used Cox models that were controlled for 7 covariates, with usual alcohol intake studied categorically compared with that in subjects who did not drink alcohol. Heavier drinkers (> or =3 drinks/day) but not light to moderate drinkers had increased risk of non-CAD-HF; e.g., relative risk for subjects who reported > or =6 drinks/day was 1.7 (95% confidence interval 1.1 to 2.6). This association of non-CAD-HF with heavy drinking was limited to subsets with cardiomyopathy or of unclear preponderant etiology. Alcohol drinking was inversely related to risk of CAD-HF (e.g., at 1 to 2 drinks/day, relative risk 0.6, 95% confidence interval 0.5 to 0.7), with consistency across subgroups of age, gender, ethnicity, education, smoking status, interval to diagnosis, and presence or absence of baseline heart disease or systemic hypertension. Moderate drinking was inversely related to non-CAD-HF only in subjects who had diabetes mellitus (n = 252). In conclusion, heavy, but not light, alcohol drinking is associated with increased risk of non-CAD-HF and that apparent protection by alcohol drinking against CAD-HF risk provides confirmation of a protective effect of alcohol against CAD. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/16054455/Alcohol_drinking_and_risk_of_hospitalization_for_heart_failure_with_and_without_associated_coronary_artery_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(05)00729-0 DB - PRIME DP - Unbound Medicine ER -