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Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana.
Acta Trop. 2005 Sep; 95(3):194-203.AT

Abstract

The emergence and spread of Plasmodium falciparum resistance to commonly used antimalarials such as chloroquine and sulphadoxine/pyrimethamine poses major challenges to malaria control in sub-Saharan Africa. We undertook a study on the efficacy of some antimalarial drugs in 2003 with the view of supporting the National Malaria Control Programme in the review of the antimalarial drug treatment policy in Ghana. Children aged 6-59 months with signs/symptoms of uncomplicated malaria including axillary temperature > or =37.5 degrees C; mono infection with P. falciparum; and parent's willingness to give consent, were randomized into four treatment groups and followed up for a maximum of 28 days. The treatment groups were chloroquine (CHQ), sulphadoxine/pyrimethamine (SP), amodiaquine+artesunate (ADQ+ART) combination, and artemether+lumefantrine (Coartem) combination. Clinical evaluation of 168 children studied showed that cumulative pcr-corrected cure rates on day 28 were 100% for ADQ+ART; 97.5% for coartem, 60% for SP and 25% for CHQ. The artemisinin-based combinations effected rapid fever and parasite clearance. Prevalence of gametocytaemia was highest in the SP group whilst the CHQ group did not show any significant changes in haemoglobin levels during the follow-up period. The findings are in agreement with current recommendations for using artemisinin-based combinations for treating uncomplicated malaria in areas of high CHQ failure such as Ghana.

Authors+Show Affiliations

Epidemiology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. kkoram@noguchi.mimcom.netNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16054584

Citation

Koram, Kwadwo A., et al. "Comparative Efficacy of Antimalarial Drugs Including ACTs in the Treatment of Uncomplicated Malaria Among Children Under 5 Years in Ghana." Acta Tropica, vol. 95, no. 3, 2005, pp. 194-203.
Koram KA, Abuaku B, Duah N, et al. Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana. Acta Trop. 2005;95(3):194-203.
Koram, K. A., Abuaku, B., Duah, N., & Quashie, N. (2005). Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana. Acta Tropica, 95(3), 194-203.
Koram KA, et al. Comparative Efficacy of Antimalarial Drugs Including ACTs in the Treatment of Uncomplicated Malaria Among Children Under 5 Years in Ghana. Acta Trop. 2005;95(3):194-203. PubMed PMID: 16054584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana. AU - Koram,Kwadwo A, AU - Abuaku,Benjamin, AU - Duah,Nancy, AU - Quashie,Neils, PY - 2005/06/08/received PY - 2005/06/08/accepted PY - 2005/8/2/pubmed PY - 2005/10/13/medline PY - 2005/8/2/entrez SP - 194 EP - 203 JF - Acta tropica JO - Acta Trop VL - 95 IS - 3 N2 - The emergence and spread of Plasmodium falciparum resistance to commonly used antimalarials such as chloroquine and sulphadoxine/pyrimethamine poses major challenges to malaria control in sub-Saharan Africa. We undertook a study on the efficacy of some antimalarial drugs in 2003 with the view of supporting the National Malaria Control Programme in the review of the antimalarial drug treatment policy in Ghana. Children aged 6-59 months with signs/symptoms of uncomplicated malaria including axillary temperature > or =37.5 degrees C; mono infection with P. falciparum; and parent's willingness to give consent, were randomized into four treatment groups and followed up for a maximum of 28 days. The treatment groups were chloroquine (CHQ), sulphadoxine/pyrimethamine (SP), amodiaquine+artesunate (ADQ+ART) combination, and artemether+lumefantrine (Coartem) combination. Clinical evaluation of 168 children studied showed that cumulative pcr-corrected cure rates on day 28 were 100% for ADQ+ART; 97.5% for coartem, 60% for SP and 25% for CHQ. The artemisinin-based combinations effected rapid fever and parasite clearance. Prevalence of gametocytaemia was highest in the SP group whilst the CHQ group did not show any significant changes in haemoglobin levels during the follow-up period. The findings are in agreement with current recommendations for using artemisinin-based combinations for treating uncomplicated malaria in areas of high CHQ failure such as Ghana. SN - 0001-706X UR - https://www.unboundmedicine.com/medline/citation/16054584/Comparative_efficacy_of_antimalarial_drugs_including_ACTs_in_the_treatment_of_uncomplicated_malaria_among_children_under_5_years_in_Ghana_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-706X(05)00157-9 DB - PRIME DP - Unbound Medicine ER -