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Single voxel proton magnetic resonance spectroscopy in women with and without intimate partner violence-related posttraumatic stress disorder.
Psychiatry Res. 2005 Aug 30; 139(3):249-58.PR

Abstract

Preliminary in vivo proton magnetic spectroscopic ((1)H-MRS) studies of N-acetylaspartate (a putative marker of neuronal viability and function) in combat veterans and maltreated children with posttraumatic stress disorder (PTSD) suggest altered neuronal integrity in anterior cingulate and medial temporal lobe structures. In this study, (1)H-MRS was used to measure N-acetylaspartate (NAA), choline (Cho) and myo-inositol (mI) relative to creatine (Cr) in the anterior cingulate of 16 women with histories of intimate partner violence (7 with a DSM-IV diagnosis of PTSD, 9 without PTSD) and 11 healthy, non-abused comparison subjects. The relationship between anterior cingulate chemistry and performance on the Stroop Color-Word task and Part B of the Trail Making Test was also examined. There were no significant differences in anterior cingulate or occipital gray matter metabolite ratios of NAA/Cr and Cho/Cr between intimate partner violence and healthy comparison subjects. Intimate partner violence subjects with PTSD had significantly higher anterior cingulate Cho/Cr than intimate partner violence subjects without PTSD. There was evidence that the subjects with PTSD suffered more severe intimate partner violence as measured by the Conflict Tactics Scale-Revised. Metabolite ratios were not significantly correlated with performance on the Stroop or Trails B. Our findings, in agreement with earlier studies, showed significant alterations in anterior cingulate chemistry in women with PTSD. In contrast to other studies, we found an increase in Cho/Cr rather than a decrease in NAA/Cr, indicating alterations in glia, instead of neuronal dropout.

Authors+Show Affiliations

MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, P.O. Box 19063, Tygerberg, 7505 Cape Town, South Africa. sseedat@sun.ac.zaNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16055312

Citation

Seedat, Soraya, et al. "Single Voxel Proton Magnetic Resonance Spectroscopy in Women With and Without Intimate Partner Violence-related Posttraumatic Stress Disorder." Psychiatry Research, vol. 139, no. 3, 2005, pp. 249-58.
Seedat S, Videen JS, Kennedy CM, et al. Single voxel proton magnetic resonance spectroscopy in women with and without intimate partner violence-related posttraumatic stress disorder. Psychiatry Res. 2005;139(3):249-58.
Seedat, S., Videen, J. S., Kennedy, C. M., & Stein, M. B. (2005). Single voxel proton magnetic resonance spectroscopy in women with and without intimate partner violence-related posttraumatic stress disorder. Psychiatry Research, 139(3), 249-58.
Seedat S, et al. Single Voxel Proton Magnetic Resonance Spectroscopy in Women With and Without Intimate Partner Violence-related Posttraumatic Stress Disorder. Psychiatry Res. 2005 Aug 30;139(3):249-58. PubMed PMID: 16055312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single voxel proton magnetic resonance spectroscopy in women with and without intimate partner violence-related posttraumatic stress disorder. AU - Seedat,Soraya, AU - Videen,John S, AU - Kennedy,Colleen M, AU - Stein,Murray B, PY - 2004/11/04/received PY - 2005/06/04/accepted PY - 2005/8/2/pubmed PY - 2005/10/21/medline PY - 2005/8/2/entrez SP - 249 EP - 58 JF - Psychiatry research JO - Psychiatry Res VL - 139 IS - 3 N2 - Preliminary in vivo proton magnetic spectroscopic ((1)H-MRS) studies of N-acetylaspartate (a putative marker of neuronal viability and function) in combat veterans and maltreated children with posttraumatic stress disorder (PTSD) suggest altered neuronal integrity in anterior cingulate and medial temporal lobe structures. In this study, (1)H-MRS was used to measure N-acetylaspartate (NAA), choline (Cho) and myo-inositol (mI) relative to creatine (Cr) in the anterior cingulate of 16 women with histories of intimate partner violence (7 with a DSM-IV diagnosis of PTSD, 9 without PTSD) and 11 healthy, non-abused comparison subjects. The relationship between anterior cingulate chemistry and performance on the Stroop Color-Word task and Part B of the Trail Making Test was also examined. There were no significant differences in anterior cingulate or occipital gray matter metabolite ratios of NAA/Cr and Cho/Cr between intimate partner violence and healthy comparison subjects. Intimate partner violence subjects with PTSD had significantly higher anterior cingulate Cho/Cr than intimate partner violence subjects without PTSD. There was evidence that the subjects with PTSD suffered more severe intimate partner violence as measured by the Conflict Tactics Scale-Revised. Metabolite ratios were not significantly correlated with performance on the Stroop or Trails B. Our findings, in agreement with earlier studies, showed significant alterations in anterior cingulate chemistry in women with PTSD. In contrast to other studies, we found an increase in Cho/Cr rather than a decrease in NAA/Cr, indicating alterations in glia, instead of neuronal dropout. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/16055312/Single_voxel_proton_magnetic_resonance_spectroscopy_in_women_with_and_without_intimate_partner_violence_related_posttraumatic_stress_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4927(05)00088-0 DB - PRIME DP - Unbound Medicine ER -