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Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease.
J Mol Neurosci 2005; 27(1):23-7JM

Abstract

Increased total plasma homocysteine (t-Hcy) levels are found to be associated with Alzheimer's disease (AD). Because the methylenetetrahydrofolate reductase (MTHFR) gene encodes a key enzyme that influences the metabolism of homocysteine, it has been considered as a possible genetic risk factor for AD. Although the MTHFR gene C677T polymorphism has a significant impact on reducing enzyme activity and increasing t-Hcy concentrations, the association between the C677T polymorphism and AD remains inconclusive. To determine whether the MTHFR gene C677T polymorphism contributes to the risk for late-onset AD (LOAD) in Chinese, we have investigated 104 sporadic LOAD patients and 130 healthy controls. The strong associations of the TT genotype and T-allele with LOAD (p 0.001, OR 5.73 95% CI 1.85-17.72, and p 0.002, OR 1.89 95% CI 1.25-2.86) were found. After stratifying by apolipoprotein E allele 4 (APOE epsilon4) status, increased LOAD risks associated with the TT genotype only in the APOE epsilon4 noncarriers (chi2=8.92, df=1, p=0.003) and with the T-allele in either group (chi2=5.18, df=1, p=0.023 and chi2=5.53, df=1, p=0.019) were seen. These results suggest that as an APOE epsilon4 allele-dependent risk factor, the MTHFR gene C677T polymorphism is involved in developing LOAD in Chinese.

Authors+Show Affiliations

Center for Human and Animal Genetics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16055944

Citation

Wang, Binbin, et al. "Association of MTHFR Gene Polymorphism C677T With Susceptibility to Late-onset Alzheimer's Disease." Journal of Molecular Neuroscience : MN, vol. 27, no. 1, 2005, pp. 23-7.
Wang B, Jin F, Kan R, et al. Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease. J Mol Neurosci. 2005;27(1):23-7.
Wang, B., Jin, F., Kan, R., Ji, S., Zhang, C., Lu, Z., ... Wang, L. (2005). Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease. Journal of Molecular Neuroscience : MN, 27(1), pp. 23-7.
Wang B, et al. Association of MTHFR Gene Polymorphism C677T With Susceptibility to Late-onset Alzheimer's Disease. J Mol Neurosci. 2005;27(1):23-7. PubMed PMID: 16055944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease. AU - Wang,Binbin, AU - Jin,Feng, AU - Kan,Rui, AU - Ji,Shun, AU - Zhang,Chuanfang, AU - Lu,Zeping, AU - Zheng,Chenguang, AU - Yang,Ze, AU - Wang,Li, PY - 2004/12/31/received PY - 2005/01/07/accepted PY - 2005/8/2/pubmed PY - 2005/10/14/medline PY - 2005/8/2/entrez SP - 23 EP - 7 JF - Journal of molecular neuroscience : MN JO - J. Mol. Neurosci. VL - 27 IS - 1 N2 - Increased total plasma homocysteine (t-Hcy) levels are found to be associated with Alzheimer's disease (AD). Because the methylenetetrahydrofolate reductase (MTHFR) gene encodes a key enzyme that influences the metabolism of homocysteine, it has been considered as a possible genetic risk factor for AD. Although the MTHFR gene C677T polymorphism has a significant impact on reducing enzyme activity and increasing t-Hcy concentrations, the association between the C677T polymorphism and AD remains inconclusive. To determine whether the MTHFR gene C677T polymorphism contributes to the risk for late-onset AD (LOAD) in Chinese, we have investigated 104 sporadic LOAD patients and 130 healthy controls. The strong associations of the TT genotype and T-allele with LOAD (p 0.001, OR 5.73 95% CI 1.85-17.72, and p 0.002, OR 1.89 95% CI 1.25-2.86) were found. After stratifying by apolipoprotein E allele 4 (APOE epsilon4) status, increased LOAD risks associated with the TT genotype only in the APOE epsilon4 noncarriers (chi2=8.92, df=1, p=0.003) and with the T-allele in either group (chi2=5.18, df=1, p=0.023 and chi2=5.53, df=1, p=0.019) were seen. These results suggest that as an APOE epsilon4 allele-dependent risk factor, the MTHFR gene C677T polymorphism is involved in developing LOAD in Chinese. SN - 0895-8696 UR - https://www.unboundmedicine.com/medline/citation/16055944/Association_of_MTHFR_gene_polymorphism_C677T_with_susceptibility_to_late_onset_Alzheimer's_disease_ L2 - https://dx.doi.org/10.1385/JMN:27:1:023 DB - PRIME DP - Unbound Medicine ER -