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The vagus nerve and the nicotinic anti-inflammatory pathway.
Nat Rev Drug Discov. 2005 Aug; 4(8):673-84.NR

Abstract

Physiological anti-inflammatory mechanisms are selected by evolution to effectively control the immune system and can be exploited for the treatment of inflammatory disorders. Recent studies indicate that the vagus nerve (which is the longest of the cranial nerves and innervates most of the peripheral organs) can modulate the immune response and control inflammation through a 'nicotinic anti-inflammatory pathway' dependent on the alpha7-nicotinic acetylcholine receptor (alpha7nAChR). Nicotine has been used in clinical trials for the treatment of ulcerative colitis, but its clinical applications are limited by its unspecific effects and subsequent toxicity. This article reviews recent advances supporting the therapeutic potential of selective nicotinic agonists in several diseases. Similar to the development of alpha- and beta-agonists for adrenoceptors, selective agonists for alpha7nAChR could represent a promising pharmacological strategy against infectious and inflammatory diseases.

Authors+Show Affiliations

Center of Immunology and Inflammation, Institute for Medical Research, North Shore University Hospital, 350 Community Drive, New York 11030, USA. Mail@LuisUlloa.com

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16056392

Citation

Ulloa, Luis. "The Vagus Nerve and the Nicotinic Anti-inflammatory Pathway." Nature Reviews. Drug Discovery, vol. 4, no. 8, 2005, pp. 673-84.
Ulloa L. The vagus nerve and the nicotinic anti-inflammatory pathway. Nat Rev Drug Discov. 2005;4(8):673-84.
Ulloa, L. (2005). The vagus nerve and the nicotinic anti-inflammatory pathway. Nature Reviews. Drug Discovery, 4(8), 673-84.
Ulloa L. The Vagus Nerve and the Nicotinic Anti-inflammatory Pathway. Nat Rev Drug Discov. 2005;4(8):673-84. PubMed PMID: 16056392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The vagus nerve and the nicotinic anti-inflammatory pathway. A1 - Ulloa,Luis, PY - 2005/8/2/pubmed PY - 2005/9/9/medline PY - 2005/8/2/entrez SP - 673 EP - 84 JF - Nature reviews. Drug discovery JO - Nat Rev Drug Discov VL - 4 IS - 8 N2 - Physiological anti-inflammatory mechanisms are selected by evolution to effectively control the immune system and can be exploited for the treatment of inflammatory disorders. Recent studies indicate that the vagus nerve (which is the longest of the cranial nerves and innervates most of the peripheral organs) can modulate the immune response and control inflammation through a 'nicotinic anti-inflammatory pathway' dependent on the alpha7-nicotinic acetylcholine receptor (alpha7nAChR). Nicotine has been used in clinical trials for the treatment of ulcerative colitis, but its clinical applications are limited by its unspecific effects and subsequent toxicity. This article reviews recent advances supporting the therapeutic potential of selective nicotinic agonists in several diseases. Similar to the development of alpha- and beta-agonists for adrenoceptors, selective agonists for alpha7nAChR could represent a promising pharmacological strategy against infectious and inflammatory diseases. SN - 1474-1776 UR - https://www.unboundmedicine.com/medline/citation/16056392/The_vagus_nerve_and_the_nicotinic_anti_inflammatory_pathway_ L2 - https://doi.org/10.1038/nrd1797 DB - PRIME DP - Unbound Medicine ER -